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From Marker Antigens for T Lymphocyte Subsets to Molecules that Regulate Cell Activation

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Progress in Immunology

Abstract

Determinants of the CD4, CD8 and CD45 antigens provide markers that distinguish subsets of T lymphocytes. In each case these antigens were identified at early stages in the development of different technical approaches to the analysis of the lymphocyte cell surface. Then the definition of T cell subsets became the focus of interest to be followed by structural analysis of the antigens. Most recently the structural studies have led to new functional insights and these antigens can now be grouped together as molecules that appear to regulate the state of phosphorylation of tyrosine residues in cytoplasmic domains of receptors involved in signal transduction. Given that tyrosine phosphorylation plays a key role in the activation cascade, the subset markers are likely to be important regulatory molecules in cell activation.

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Authors
  1. A. F. Williams
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  2. A. D. Beyers
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Editor information

Editors and Affiliations

  1. Basel Institute for Immunology, Grenzacherstrasse 487, 4005, Basel, Switzerland

    Fritz Melchers , H. von Boehmer  & L. Du Pasquier ,  & 

  2. Labor für Immungenetik, Kinderpoliklinik der Universität, Pettenkoferstrasse 8a, 8000, München 2, Germany

    E. D. Albert

  3. Institut für Hygiene, Universität Innsbruck und Ludwig Boltzmann-Institut für AIDS-Forschung, Fritz-Pregl-Strasse 3, 6010, Innsbruck, Austria

    M. P. Dierich

  4. Max-Planck-Institut für Immunbiologie, Stübeweg 51, 7800, Freiburg, Germany

    K. Eichmann

  5. Med.Zentrum für Hygiene und Medizinische Mikrobiologie, Institut für Immunologie, Robert-Koch-Straße 8, 3550, Marburg, Germany

    D. Gemsa

  6. Abteilung Immunologie, Zentrum Hygiene und Humangenetik, Kreuzbergring 57, 3400, Göttingen, Germany

    O. Götze

  7. Institut und Poliklinik für klinische Immunologie und Rheumatologie, Krankenhausstraße 12, 8520, Erlangen, Germany

    J. R. Kalden

  8. Abt.Med.Mikrobiologie und Immunologie der Universität, Albert-Einstein-Allee 11, 7900, Ulm/Donau, Germany

    S. H. E. Kaufmann

  9. Institut für Immunologie Transfusionsmedizin, Ratzeburger Allee 160, 2400, Lübeck 1, Germany

    H. Kirchner

  10. Medizinische Hochschule Hannover Molekularpharmakologie, Konstanty-Gutschow-Strasse 8, 3000, Hannover 61, Germany

    K. Resch

  11. Institut für Immunologie, Ludwig-Maximilians-Universität, Goethestrasse 31, 8000, München 2, Germany

    G. Riethmüller

  12. Institut für Virologie und Immunbiologie, Versbacher Strasse 7, 8700, Würzburg, Germany

    A. Schimpl

  13. Zentrum für Dermatologie Institut für Experimentelle Dermatologie, Von-Esmarch-Strasse 56, 4400, Münster, Germany

    C. Sorg

  14. F.Hoffmann-La Roche Co Ltd, ZFE, 4002, Basel, Switzerland

    M. Steinmetz

  15. Inst. für Med. Mikrobiologie und Hygiene, TU München Klinikum rechts der Isar, Trogerstrasse 9, 8000, München 80, Germany

    H. Wagner

  16. Institut für Physiologische Chemie, Universität München, Goethestr. 33, 8000, München 2, Germany

    H. G. Zachau

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Williams, A.F., Beyers, A.D. (1989). From Marker Antigens for T Lymphocyte Subsets to Molecules that Regulate Cell Activation. In: Melchers, F., et al. Progress in Immunology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-83755-5_18

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  • DOI: https://doi.org/10.1007/978-3-642-83755-5_18

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-83757-9

  • Online ISBN: 978-3-642-83755-5

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