Evolutions of the Immune System

  • L. Du Pasquier
  • J. Schwager


Determining the relative importance of the elements of the immune sytem is a major task to which comparative studies may help first in pointing to key elements and second in suggesting their phylogenetic origin. These comparative analyses are complicated by many difficulties due to the following facts. 1) The immune system coevolved with the other physiological systems of the organism and its evolution should not be considered as the evolution of a single independent entity. 2) With respect to the history of the system one has a very incomplete and perhaps misleading view of the phylogeny of the Animal Kingdom. 3) The immune system with what we know of its genetic multiplicity is going to be a complex evolving unit with probably an enormous amount of flexibility enabling some of its elements to evolve in a few generations perhaps as fast as in the history of the species, not to mention its somatic evolution during ontogeny.


Recombination Signal Sequence Antibody Diversity Allelic Exclusion Vertebrate Immune System Heavy Chain Locus 
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  1. Du Pasquier L (1989) Evolution of the immune system. In: W Paul Fundamental Immunology, 2nd edition, Raven Press NY, in pressGoogle Scholar
  2. Du Pasquier L, Schwager J, Flajnik MF (1989) The immune system of Xenopus. Ann Rev Immunol 7:251–275CrossRefGoogle Scholar
  3. Edelman GM (1987) CAMS and Igs: cell adhesion and the evolutionary origin of immunity. Immunol Rev 100:9–43CrossRefGoogle Scholar
  4. Flajnik MF, Hsu E, Kaufman JF, Du Pasquier L (1987) Changes in the immune system during metamorphosis of Xenopus. Immunol Today 8:58–64CrossRefGoogle Scholar
  5. Flajnik MF, Du Pasquier L (1989) Changes in the expression of the major histocompatibility complex during the ontogeny of Xenopus. Proc ICN-UCLA meeting on Developmental Biology, Dev Biol, in pressGoogle Scholar
  6. Harrelson AL, Goodman CS (1988) Growth cone guidance in insects: fascilin II is a member of the immunoglobulin superfamily. Science 242:700–705PubMedCrossRefGoogle Scholar
  7. Hsu E, Schwager J, Alt F (1989) Evolution of immunoglobulin genes: Vji families in the amphibian Xenopus. Proc Natl Acad Sci USA, in pressGoogle Scholar
  8. Kaufman JF (1989) Evolution of the MHC: lessons from the non- mammalian vertebrates. Immunological Research, Karger, Basel, in pressGoogle Scholar
  9. Kobel HR, Du Pasquier L (1986) Genetic of polyploid Xenopus. Trends Genet 2:310–315CrossRefGoogle Scholar
  10. Kokubu F, Hinds K, Litman R, Shamblott MJ, Litman GW (1988a) Complete structure and organization of immunoglobulin heavy chain constant region genes in a phylogenetically primitive vertebrate. EMBO J 7:1979–1988PubMedCentralPubMedGoogle Scholar
  11. Kokubu F, Litman R, Shamblott MJ, Hinds K, Litman GW (1988 b) Diverse organization of immunoglobulin Vjj gene loci in a primitive vertebrate. EMBO J 7:3413–3422PubMedCentralPubMedGoogle Scholar
  12. Kudo A, Sakaguchi N, Melchers F (1987) Organization of the murine Ig-related 5 gene transcribed selectively in pre-B lymphocytes. EMBO J 6:103–107PubMedCentralPubMedGoogle Scholar
  13. Reinisch CL, Litman GW (1989) Evolutionary immunobiolgy. Immunol Today 10.278–281PubMedCrossRefGoogle Scholar
  14. Reynaud CA, Dahan A, Anquez V, Weill JC (1989) Somatic hyperconversion diversifies the single Vh gene of the chicken with a high incidence in the D region. Cell, in pressGoogle Scholar
  15. Schwager J, Mikoryak A, Steiner LA (1988a) Amino acid sequence of heavy chain from Xenopus laevls IgM deduced from cDNA sequence: Implications for evolution of immunoglobulin domains. Proc Natl Acad Sci USA 85:2245–2249PubMedCentralPubMedCrossRefGoogle Scholar
  16. Schwager J, Grossberger D, Du Pasquier L (1988b) Organization and rearrangement of immunoglobulin M genes in the amphibian Xenopus. EMBO J 7:2409–2415PubMedCentralPubMedGoogle Scholar
  17. Schwager J, Burckert N, Courtet M, Du Pasquier L (1989) Genetic basis of the antibody repertoire in Xenopus: analysis of the Vh diversity. EMBO J, in pressGoogle Scholar
  18. Seeger MA, Haffley L, Kaufman TC (1988) Characterization of amalgam a member of the immunoglobulin superfamily from Drosophila. Cell 55:589–600PubMedCrossRefGoogle Scholar
  19. Shamblott MJ, Litman GW (1989) Complete nucleotide sequence of primitive Vertebrate immunogobulin light chain gene. Proc Natl Acad Sci USA 86:4684–4688PubMedCentralPubMedCrossRefGoogle Scholar
  20. Siminovitch KA, Bakhshi A, Goldman P, Korsmeyer SJ (1985) A uniform deleting element mediates the loss of k genes in human B cells. Nature 316:260–262PubMedCrossRefGoogle Scholar
  21. Williams AF, Barclay AN (1988) The immunoglobulin superfamily domains for cell surface recognition. Ann Rev Immunol 6:381CrossRefGoogle Scholar

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© Springer-Verlag Berlin Heidelberg 1989

Authors and Affiliations

  • L. Du Pasquier
  • J. Schwager

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