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Rapamycin: A New and Highly Active Immunosuppressive Macrolide with an Efficacy Superior to Cyclosporine

  • B. M. Meiser
  • J. Wang
  • R. E. Morris

Abstract

In 1975, as part of a program at Ayerst Research Laboratories in Montreal to screen for non-polyene antifungal antibiotics, Dr Sehgal’s group (Sehgal 1975) discovered that a fermentation product of the fungus Streptomyces hygroscopicus inhibited Candida albicans and dermatophytes (Vézina 1975; Baker 1978; Singh 1979). The active anti-fungal principle was isolated and determined to be a novel 31-membered macrolide lactone with a FW of 914.2 and the molecular formula C51H79NO13 (Swindells 1978). The antibiotic was named rapamycin (RPM) since the streptomycete had been isolated from a soil sample collected during an expedition of caves on Easter Island (Rapa nui).

Keywords

Graft Survival Allograft Survival Brown Norway Heart Graft Prolong Graft Survival 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1989

Authors and Affiliations

  • B. M. Meiser
  • J. Wang
  • R. E. Morris

There are no affiliations available

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