High Degeneracy of HLA DR-Peptide Interactions: Possible Ramifications for Vaccine Design
The demonstration that both MHC class I and class II molecules bind fragments of protein antigens (Babbitt 1985, Buus 1986, Watts and McConnell 1986) and that the formation of MHC-peptide complexes is a necessary requirement for T cell recognition (Schwartz 1985) has led to the postulate that the differential capacity of each allele to bind peptides is the molecular basis of genetic differences in immune responsiveness (Guillet 1987, Buus 1987). The results of the binding studies supported experiments demonstrating that the specificity of the cellular immune response to an immunogen varies between different strains of mice. Consequently, any peptide based vaccine must be composed of a suffiently large cocktail of peptides to be widely effective. However, these conclusions were based principally on the binding studies using purified murine class II MHC molecules and consequently only a limited number of alleles were examined.
KeywordsFluorescent Signal Peptide Binding Cell Determinant Natural Determinant Murine Class
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