T Cell-Mediated Tumor Regression in Experimental Systems

  • R. J. North
  • M. Awwad
  • P. L. Dunn


It was established in the 1950s and 60s (Old and Boyce 1964; Sjögren 1965; Klein 1966; Hellström and Hellström 1969) that murine tumors can possess transplantation rejection antigens capable of evoking an antitumor immune response in their syngeneic hosts. It was also established that antitumor immunity is cell-mediated. In the 1970s a great deal of effort led to the realization that, in spite of their possession of rejection antigens, immunogenic tumors are highly resistant to attempts to cause their regression by immunotherapeutic modalities that employ immunoadjuvants (Bast et al. 1976). Consequently examples of successful active immunotherapy of immunogenic tumors are rare. In contrast, it has become almost routine to cause the regression of established murine tumors by adoptive immunization with immune T cells from immunized donors. The convincing success of adoptive immunotherapy serves to demonstrate that immunogenic tumors fail to undergo regression because of a shortfall in host effector lymphocytes, rather than because of some tumor-mediated anti- host mechanism that blocks the expression of immunity. It is perhaps time again, therefore, to work at discovering ways to stimulate the host itself to produce therapeutic numbers of effector lymphocytes, rather than to supply it with T cells from immune donors, or with tumor-infiltrating lymphocytes expanded in number in vitro. It will be argued here that, in order for anti-tumor immunity to be augmented to a therapeutic level, it is necessary, in the case of some tumors, to remove the negative regulatory influence of tumor-induced suppressor T cells. Indeed, it needs to be realized that removing the influence of suppressor cells is also a prerequisite for successful adoptive immunotherapy as practiced at present.


Antitumor Immunity Antitumor Immune Response Adoptive Immunotherapy Tumor Bearer Immunogenic Tumor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Berlin Heidelberg 1989

Authors and Affiliations

  • R. J. North
  • M. Awwad
  • P. L. Dunn

There are no affiliations available

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