Genetic Regulation of HIV

  • F. Wong-Staal
Conference paper

Abstract

Not all retrovirus infections require active viral replication to accelerate the disease course. A good case in point is Adult T-cell Leukemia associated with the human Leukemia Virus, HTLV-1. Once the patient is diagnosed with ATL, there is no sign of virus expression of any kind in the tumor cells. In contrast, clinical progression in AIDS does correlate with elevated level of virus expression and continuous recruitment of new infected cells. There are several important implications from this observation: (1) Regulation of HIV expression by viral and cellular factors play a key role in AIDS pathogenesis. (2) Exogenous factors may contribute to clinical progression. (3) Agents that inhibit the virus replication cycle would be appropriate therapeutic agents. In this paper, I would focus on two regulatory genes of HIV relating to their function and their potential use as targets in antiviral therapy.

Keywords

Codon Leukemia Oligomer eDNA Oate 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Bibliography

  1. Franchini G, Fargnoli KA, Giombini F, Jagodzinski L, De Rossi A, Bosch M, Biberfeld G, Fenyo EM, Albert J, Gallo RC, and Wong-Staal F (1989): Molecular and biological characterization of a replication competent human immunodeficiency type 2 (HIV-2) proviral clone. Proc. Natl. Acad. Sci., USA 86: 2433–2437PubMedCentralPubMedCrossRefGoogle Scholar
  2. Franza R, Cullen B, and Wong-Staal F. (Eds): The Control of Human Retrovirus Gene Expression. New York, Cold Spring Harbor Press, 1988.Google Scholar
  3. Malim MH, Bohnlein S, Hauber J, and Cullen BR (1989b): Functional Dissection of the HIV-1 rev Trans-activation Derivation of a Trans-Dominant Repressor of rev Function. Cell, in press.Google Scholar
  4. Matsukura M, Zon G, Shinozuka K, Robert-Guroff M, Shimada T, Stein CA, Mitsuya H, Wong-Staal F, Cohen JS, Broder S: Regulation of viral expression of HIV (human immunodeficiency virus) in vitro by an antisense phosphorothioate oligodeoxynucleotide against rev (art/trs) in chronically infected cells. Proc. Natl. Acad. Sci. USA, in press.Google Scholar
  5. Rappaport J, Lee S-J, Kamel K, and Wong-Staal F: The acidic amino-terminal region of the HIV-1 tat protein consitutes an essential activiating domain (1989). The New Biologist, in press.Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1989

Authors and Affiliations

  • F. Wong-Staal

There are no affiliations available

Personalised recommendations