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Measlesvirus-Induced Cellular Autoimmune Reactions

  • U. G. Liebert
  • V. ter Meulen
Conference paper

Summary

Subacute encephalomyelitis (SAME) in Lewis rats following infection with a neurotropic measles virus (MV) is associated with a cellmediated autoimmune response (CMAI) to myelin basic protein (MBP) and proteolipid apoprotein (PLP). Grown in vitro the autoreactive T cell lines are CD4+, class II MHC-restricted, and the MBP-specific T cell lines are encephalitogenic when adoptively transferred into naive recipients. MBP-selected CD4+ T cell lines both from measles infected animals as well as from rats with experimental allergic encephalomyelitis (EAE), as a consequence of challenge with MBP, shared the same antigenicspecificity. Our data indicate that MV infection of the central nervous system (CNS) enhances the susceptibility of the CNS to autoimmune T cell aggression.

Keywords

Myelin Basic Protein Measle Virus Experimental Allergic Encephalomyelitis Stimulation Index Acute Measle 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1989

Authors and Affiliations

  • U. G. Liebert
  • V. ter Meulen

There are no affiliations available

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