T Cell Vaccination and Suppression of Autoimmune Disease
Immunological suppression may be defined as inhibition of an immune response in the face of an otherwise adequate stimulus. Based largely on investigations of the induction of “infectious tolerance” to foreign antigens (Gershon and Kondo, 1970), it was once widely accepted that immunological suppression was the task of a special class of CD8 suppressor T cells that specifically recognized the tolerogen (Dorf and Benacerraf, 1984). However, the inability of many to clone antigen-specific suppressor T cells has given rise to skepticism about the very existence of such cells.
KeywordsMycobacterium Tuberculosis Spleen Cell Suppressor Cell Cell Vaccination Idiotypic Network
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