Abstract
The three years frequency of the International Immunology Congresses make them appropriate to consider the place of progress in a given area. This decade was certainly marked by the structural solution of the T cell receptor problem, first announced in Kyoto (1983). However, if less dramatically, the common sense in other central areas of Immunology has also significantly evolved. This is particularly evident in what concerns autoimmunity. While in 1980 (Paris), there was hardly any mention of autoimmune reactivities in normal individuals, we are starting the 1989 Congress with Symposium lectures on the physiology of autoimmunity. The previous decade had seen the isolation and description of very promising animal models of spontaneous and induced autoimmune diseases, an increasingly powerful technology, and the demonstrations that “important” diseases (e.g., diabetes) were actually autoimmune. Many immunologists were attracted to this area, and the greatest expectations could be entertained. The present consensus is less optimistic and, in spite of much work, it seems that we have advanced very little towards the goal of treating and/or preventing autoimmune disease. We do feel, however, that the increasing attention given to autoreactivities in normal individuals, and the shift in perspective that this implies, have opened new possibilities: we can now compare physiology with pathology of autoreactivity, while not longer than 10 years ago, we were trying to understand autoimmune disease with no information, not even consideration, of what the physiology of those processes would be.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Andersson J, Coutinho A, Lernhardt W, Melchers F. (1977) Clonal growth and maturation to immunoglobulin secretion in vitro of every growth-inducible B lymphocyte. Cell 10: 27–34
Avrameas S, Dighiero G, Lymberi P, Guilbert B (1983) Studies on natural antibodies and auto-anditodies. Ann. Immunol (Inst. Pasteur) 134D: 103
Baccala R., Vo Quang T., Gilbert M, Ternynck T., Avrameas S. (1989) Two murine natural polyreactive autoantibodies are encoded by nonmutated germ-line genes. Proc Natl Acad Sci USA, 86: 4624.
Cohn M, Langman R, Geckeier W (1980) Diversity 1980. In Progress in Immunology IV, Theme 3: Expression of Antigen receptors in lymphocytes and cellular activation mechanisms, M. Fougereau and J. Dausset Ed., Academic Press, pp. 153–202
Coutinho A (1989) Beyond clonal selection and network. Immunol Rev 110, in press
Coutinho A, Forni L, Holmberg D, Ivars F, Vaz N, (1984) From an antigen- centered, clonal perspective of immune response to an organism centered, network perspective of autonomous activity in a self- referential immune system. Immunol Rev 79: 151–168
Coutinho A, Bandeira A, Pereira P, Portnoi D, Holmberg D, Martinez- A. C, Freitas A (1989) Selection of lymphocyte repertoires: the limits of clonal versus network organization. In: Symposia on Quantitative Biology, Vol. 54, Cold Spring Harbor Laboratory, N.Y., in press.
Datta SK, Owen FL, Womack JE, Riblet RJ (1982) Analysis of recombinant imbred lines derived from “autoimmune” (NZB) and “high leukine” strains: independent multigenic systems control B cell hyperactivity, retrovirus expression and autoimmunity. J Immunol 129: 1539- 1544
Dighiero G, Lymberi P, Mazie JC, Rouyre S, Butler-Browne GS, Whalen RG, Avrameas S (1983) Murine hybridomas secreting natural monoclonal antibodies reacting with self antigens. J Immunol 131: 2267–2272
Dighiero G, Lymberi P, Holmberg D, Lundkvist I, Coutinho A, Avrameas S (1985) High frequency of natural autoantibodies in normal newborn mice. J Immunol 134: 765–771
Gleichmann E, Gleichmann H and Wilke W (1976). Autoimmunization and lymphomagenesis in parent—Fl combinations differing at the major histocompatibility complex: model for spontaneous disease caused by altered self-antigens ? Transplant Rev 31: 156–224
Goodnow CC, Crosbie J, Adelstein S, Lavoie TB, Smith-Gill SJ, Brink RA, Pritchard-Briscoe H, Wotherspoon JS, Lablay RH, Raphael K, Trent RJ, Basten A (1988) Altered immunoglobulin expression and functional silencing of self-reactive B lymphocytes in transgenic mice. Nature 334: 676–682
Guilbert B, Dighiero G, Avrameas S, (1982) Naturally occuring antibodies against nine common antigens in human sera. I. Detection, isolation and characterisation. J Immunol 128: 2779–2787
Herzenberg LA, Stall AM, Lalor PA, Sidman C, Moore WA, Parks DR, Herzenberg LA (1986) The Ly-1 B cell lineage. Immunol Rev 93: 81- 102
Holmberg D, Forsgren S, Ivars F, Coutinho A (1984) Reactions amongst IgM antibodies derived from normal, neonatal mice. Eur J Immunol, 14: 453–441
Hooijkaas H, Benner R, Pleasants JR, Wostmann BS (1984) Isotypes and specificities of immunoglobulin produced by germ-free mice fed chemically defined ultrafiltrered “antigen-free” diet. Eur J Immunol 14: 1127–1130
Huetz F, Jacquemart F, Pena Rossi C, Varela F Coutinho A (1988) Autoimmunity: the moving boundaries between physiology and pathology. J Autoimmunity 1: 507–518
Huetz F, Larsson-Sciard EL, Pereira P, Portnoi D, Coutinho A (1988) T cell dependence of “natural” auto-reactive B cell activation in the spleen of normal mice. Eur J Immunol 18: 1615–1622
Izui S, Kobayakawa R, Zrid MJ, Louis J, Lambert PH (1977) Mechanisms for induction of anti-DNA antibodies by bacterial lipopolysaccharides in mice. II. Correlation between anti-DNA antibodies induction and polyclonal antibody formation by various B-lymphocyte activators. J Immunol 119: 2157–2164
Jerne NK (1974) Towards a network theory of the immune sustem. Ann Immunol (Inst. Pasteur) 125C: 373–389
Klinman DM, Ishigatsubo Y, Steinberg AD (1988) Acquisition and maturation of expressed B cell repertoires in normal and autoimmune mice. J Immunol 141: 801–806
Kotzin BL, Kappler JW, Marrack PC, Herron LR (1989) T cell tolerance to self antigens in New Zealand hybrid mice with lupus-like disease. J Immunol 143: 89–94
Lo D, Burkly LC, Widera G, Cowing C, Flavell RA, Palmiter RD, Brinster RL (1988) Diabetes and tolerance in transgenic mice expressing Class II MHC molecule in pancreatic beta cells. Cell 53: 159–168
Marcos MAR, De La Hera A, Gaspar ML, Márquez C, Bellas C, Mampaso F, Toribio ML, Martinez-A, C (1986) Modification of emerging repertoires by immunosuppression in immunodeficient mice results in autoimmunity. Immunol Rev 94: 51–74
Martinez -A C, Pereira P, Bernabé RR, Bandeira A, Larsson EL, Cazenave PA, Coutinho A (1984) Internal complementarities in the immune system: regulation of the expression of helper T-cell idiotypes. Proc Natl Acad Sci USA 81: 4520–4523
Martinez -A C, Pereira P, Toribio ML, Marcos MAR, Bandeira A, De La Hera A, Márquez C, Cazenave PA, Coutinho A (1988) The participation of B cells and antibodies in the selection and maintenance of T cell repertoires. Immunol Rev 94: 51–74
Naparstek J, Andra-Schwartz J, Mauser T, Wysock LJ, Bretiman L, Stollar B, Gefter M, Schwartz RS (1986) A single germ-line Vh gene segment of normal A/J mice encodes auto-antibodies characteristic of systemic lupur erythematosus. J Exp Med 164: 614–626
Nemazee DA, Burki D (1989) Clonal deletion of B lymphocytes in a transgenic mouse bearing anti-MHC Class I antibody gene. Nature 337: 562–566
Nossal GJV, Pike BL (1980) Antibody receptor diversity and diversity of signals. In Progress in Immunology IV, Theme 3: Expression of Antigen receptors in lymphocytes and cellular activation mechanisms, M. Fougereau and J. Dausset Ed., Academic Press, pp. 136–153
Pereira P, Larsson EL, Forni L, Bandeira A, Coutinho A (1985) Natural effector T lymphocytes in normal mice. Proc Natl Acad Sci USA 82: 7691–7695
Pereira P, Forni L, Larsson EL, Cooper M, Heusser C, Coutinho A (1986) Autonomous activation of B and T cells in antigen-free mice. Eur J Immunol 16: 685–688
Pobor G, Pettersson S, Larsson EL, Coutinho A (1982) Development of a quantitative assay detecting all T cells mediating helper effects for B lymphocytes, regardless of their specificity. Scand J Immunol, 15: 134 (Abst.)
Portnoi D, Freitas A, Holmberg D, Bandeira A, Coutinho A (1986) Immunocompetent autoreactive B lymphocytes are activated cycling cells in normal mice. J Exp Med 164: 25–35
Prabhakar BS, Saegusa J, Onodera R, Notkins AL (1984) Lymphocytes capable of making monoclonal autoantibodies that react with multiple organs are a common feature of the normal B cell repertoire. J Immunol 133: 2815–2817
Schlomchik MJ, Marshak-Rochstein CB, Wolfowicz TL, Rothstein A, Weigert MG (1987) The role of clonal selection and somatic mutation in autoimmunity. Nature 328: 805–811
Stewart J, Varela FJ, Coutinho A (1989) The relationship between connectivity and tolerance as revealed by computer stimulation of the immune network: some lessons for an understanding of autoimmunity. J Autoimmunity 2: 15–23
Theofilopoulos AN, Dixon FJ (1985) Murine models of systemic lupus erythematosus. Adv Immunol 37: 269–390
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1989 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Marcos, M.A.R., Sundblad, A., Grandien, A., Huetz, F., Avrameas, S., Coutinho, A. (1989). The Physiology of Autoimmune Reactivities. In: Melchers, F., et al. Progress in Immunology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-83755-5_108
Download citation
DOI: https://doi.org/10.1007/978-3-642-83755-5_108
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-83757-9
Online ISBN: 978-3-642-83755-5
eBook Packages: Springer Book Archive