Neuromediators of Immunity and Inflammation

  • E. J. Goetzl
  • C. W. Turck
  • K. E. Peterson
  • R. J. Finch
  • K. T. Kodama
  • D. C. Adelman
  • S. P. Sreedharan
Conference paper

Abstract

The nature and extent of the alterations in immunity resulting from neural lesions, and of the neural adaptation to immune reactions and inflammation suggested initially that the two systems cooperate in host defense (Ader 1981; Goetzl & Spector 1989). The elucidation of patterns of innervation of organs of the immune system, effects of immune cytokines on neuroendocrine functions, and mechanisms of response of immune cells to neuromediators has provided models and techniques for molecular and cellular studies of neuroendocrine interactions (Goetzl and Spector 1989). The findings of similar membrane protein antigens, enzymatic pathways, mediators, and receptors in some neuroendocrine and immune cells supported further the evolving concept of a multisystem network. A conceptual integration of currently available data suggests that some distinct phases of immunity and inflammation are particularly susceptible to neural influences. The potency and specificity of neuropeptide mediators in chronic immunological reactions, involving predominantly macrophages and lymphocytes, will be described as the background for discussion of recent studies of immune variants of some neuropeptides and the corresponding lymphocyte receptors.

Keywords

Histamine Sponge Prolactin PGE2 Calcitonin 

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Copyright information

© Springer-Verlag Berlin Heidelberg 1989

Authors and Affiliations

  • E. J. Goetzl
  • C. W. Turck
  • K. E. Peterson
  • R. J. Finch
  • K. T. Kodama
  • D. C. Adelman
  • S. P. Sreedharan

There are no affiliations available

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