Topical Antibiotic Regimen

  • C. P. Stoutenbeek
Conference paper
Part of the Update in Intensive Care and Emergency Medicine book series (UICM, volume 7)


Prevention of infection in intensive care with oral non-absorbable antibiotics is a new application of an old technique. In the past 30 years different patient groups have been treated with a variety of oral antibiotics to eliminate potentially pathogenic microorganisms (PPM) from the intestinal flora for many years oral antibiotics have been used to prevent perioperative wound infections [1–6]. In granulocytopenic patients extensive experience with oral antibiotics has been obtained: first the GVN regimen (consisting of gentamicin, vancomycin, and nystatin) was introduced [7], followed later by the FRACON regimen (framycetin, colistin,* nystatin) [8, 9], partial antimicrobial decontamination (PAD) [10], and selective decontamination (SDD) [11]. Also the use of the absorbable cotrimoxazole has been widely used for prophylaxis [12]. In burn patients the incidence of wound infections was reduced with oral non-absorbable antibiotics [13]. However, many of these methods have been abandoned, either because they were ineffective or because of selection of resistant strains [14–16].


Oral Antibiotic Minimal Bactericidal Concentration Intestinal Flora Klebsiella Oxytoca Acinetobacter Calcoaceticus 
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© Springer-Verlag Berlin Heidelberg 1989

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  • C. P. Stoutenbeek

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