Adenoacanthoma, Mammary Gland, Mouse

  • Sabine Rehm
Part of the Monographs on Pathology of Laboratory Animals book series (LABORATORY)


Adenoacanthomas of the mouse mammary gland are grossly similar to other tumor types of this organ, i. e., they are round or coarsely nodular, well-cirumscribed, and easily separated from adjacent normal tissue. However, adenoacanthomas contain areas of yellowish or white flaky material on the cut surface in regions of extensive keratinization.


Adenosquamous carcinoma mammary gland adenocarcinoma with squamous or epidermoid metaplasia keratinizing mammary gland tumor 


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Andervont HB, Dunn TB (1950) Response of mammarytumor-agent-free strain DBA female mice to percutaneous application of methylcholanthrene. JNCI 10: 895 - 925PubMedGoogle Scholar
  2. Asch BB, Burstein NA, Vidrich A, Sun T-T (1981) Identification of mouse mammary epithelial cells by immunofluorescence with rabbit and guinea pig antikeratin antisera. Proc Natl Acad Sci USA 78: 5643 - 5647PubMedCrossRefGoogle Scholar
  3. Asch HL, Asch BB (1985) Heterogeneity of keratin expression in mouse mammary hyperplastic alveolar nodules and adenocarcinomas. Cancer Res 45: 2760 - 2768PubMedGoogle Scholar
  4. Biancifiori C, Caschera F (1962) The relation between pseudopregnancy and the chemical induction by four carcinogens of mammary and ovarian tumours in BALB/c mice. Br J Cancer 16: 722 - 730PubMedCrossRefGoogle Scholar
  5. Bonser GM, Orr JW (1939) The morphology of 160 tumours induced by carcinogenic hydrocarbons in the subcutaneous tissues of mice. J Pathol Bacteriol 49: 171 - 183CrossRefGoogle Scholar
  6. Deringer MK (1959) Occurrence of tumors, particularly mammary tumors, in agent-free strain C3HeB mice. JNCI 22: 995 - 1002PubMedGoogle Scholar
  7. Deringer MK (1965) Occurrence of mammary tumors, reticular neoplasms, and pulmonary tumors in strain BALB/cAnDe breeding female mice. JNCI 35: 1047 - 1052PubMedGoogle Scholar
  8. Deringer MK (1969) Development of tumors, particularly mammary tumors, in agent-free substrain RIIIeB/De mice. JNCI 43: 1347 - 1351PubMedGoogle Scholar
  9. Dunn TB (1959) Morphology of mammary tumors in mice. In: Homburger F (ed) The physiopathology of cancer, 2nd edn. Hoeber-Harper, New York, pp 38 - 84Google Scholar
  10. Heston WE, Deringer MK, Dunn TB, Levillain WD (1950) Factors in the development of spontaneous mammary gland tumors in agent-free strain C3Hb mice. JNCI 10: 1139 - 1155PubMedGoogle Scholar
  11. Heston WE, Vlahakis G, Smith GH (1972) Mammary gland tumors in substrains C57BL/M and C57BL/He mice. JNCI 49: 805 - 812PubMedGoogle Scholar
  12. Hoch-Ligeti C, Liebelt AG, Congdon CC, Stewart HL (1986) Mammary gland tumors in irradiated and untreated guinea pigs. Toxicol Pathol 14: 289 - 298PubMedCrossRefGoogle Scholar
  13. Huseby RA, Bittner JJ (1946) A comparative morphological study of the mammary glands with reference to the known factors influencing the development of mammary carcinoma in mice. Cancer Res 6: 240 - 255PubMedGoogle Scholar
  14. Kirschbaum A (1949) Induction of mammary cancer with methylcholanthrene. II. Histological similarity between carcinogen-induced tumors and certain mammary neoplasms occurring spontaneously. Cancer Res 9: 93 - 95Google Scholar
  15. Kirschbaum A, Williams WL, Bittner JJ (1946) Induction of mammary cancer with methylcholanthrene. I. Histogenesis of the induced neoplasm. Cancer Res 6: 354-362Google Scholar
  16. Komitowski D, Sass B, Laub W (1982) Rat mammary tumor classification: notes on comparative aspects. JNCI 68: 147 - 156PubMedGoogle Scholar
  17. Liebelt AG, Liebelt RA (1967) Chemical factors in mammary tumorigenesis. In: Carcinogenesis: a broad critique. 20th annual MD Anderson Hospital and Tumor Institute symposium on fundamental cancer research, 1966. Williams and Wilkins, Baltimore, pp 315 - 345Google Scholar
  18. Medina D (1974) Mammary tumorigenesis in chemical carcinogen-treated mice. I. Incidence in BALB/c and C57BL mice. JNCI 53: 213 - 221PubMedGoogle Scholar
  19. Medina D (1976) Preneoplastic lesions in murine mammary cancer. Cancer Res 36: 2589 - 2595PubMedGoogle Scholar
  20. Medina D, Warner MR (1976) Mammary tumorigenesis in chemical carcinogen-treated mice. IV. Induction of mammary ductal hyperplasias. JNCI 57: 331-337Google Scholar
  21. Medina D, Butel JS, Socher SH, Miller FL (1980) Mammary tumorigenesis in 7,12-dimethylbenzanthracenetreated C57BL x DBA/2fF1 mice. Cancer Res 40: 368 - 373PubMedGoogle Scholar
  22. Moulton JE (1978) Tumors of the mammary gland. In: Moulton JE (ed) Tumors in domestic animals, 2nd edn. University of California Press, Berkeley, pp 346 - 371Google Scholar
  23. Mühlbock O, van Ebbenhorst Tengbergen W, van Rijssel TH (1952) Studies on the development of mammary tumors in dilute-brown DBAb mice without the agent. JNCI 13: 505 - 531PubMedGoogle Scholar
  24. Peters RL, Rabstein LS, Spahn GJ, Madison RM, Huebner RJ (1972) Incidence of spontaneous neoplasms in breeding and retired breeder BALB/cCr mice throughout the natural life span. Int J Cancer 10: 273 - 282PubMedCrossRefGoogle Scholar
  25. Rehm S, Rapp KG, Deerberg F (1985) Influence of food restriction and body fat on life span and tumour incidence in female outbred Han:NMRI mice and two sublines. Z Versuchstierkd 27: 240 - 283PubMedGoogle Scholar
  26. Sass B, Dunn TB (1979) Classification of mouse mammary tumors in Dunn's miscellaneous group including recently reported types. JNCI 62: 1287 - 1293PubMedGoogle Scholar
  27. Sass B, Vlahakis G, Heston WE (1982) Precursor lesions and pathogenesis of spontaneous mammary tumors in mice. Toxicol Pathol 10: 12 - 21CrossRefGoogle Scholar
  28. Scarff RW, Torloni H (eds) (1981) Histological typing of breast tumours. International histological classification of tumours, no 2, 2nd edn. WHO, GenevaGoogle Scholar
  29. Schaefer FV, Custer RP, Sorof S (1985) Induction of epidermoid differentiation by cyclic adenine nucleotide in cultured mammary tumors of mice. Cancer Res 45: 1828 - 1833PubMedGoogle Scholar
  30. Slemmer G (1974) Interactions of separate types of cells during normal and neoplastic mammary gland growth. J Invest Dermatol 63: 24 - 47PubMedCrossRefGoogle Scholar
  31. Squartini F (1979) Tumours of the mammary gland. In: Turusov VS (ed) Pathology of tumours in laboratory animals, vol II. Tumours of the mouse. IARC, Lyon, pp 43-90 (IARC Sci Publ no 23 ) Mixed Adenocarcinoma, Mammary Gland, Mouse 323Google Scholar
  32. Van der Valk MA (1981) Survivals, tumor incidence and gross pathology in 33 mouse strains. In: Hilgers J, Sluyser M (eds) Mammary tumors in the mouse. Elsevier/North-Holland, Amsterdam, pp 45 - 115Google Scholar
  33. Van Ebbenhorst Tengbergen WJPR (1970) Morphological classification of mammary tumours in the mouse. Pathol Eur 5: 260 - 272PubMedGoogle Scholar
  34. Van Zwieten MJ (1984) The rat as an animal model in breast cancer research. Martin Nijhoff/Kluwer/Academic, Boston, p 105CrossRefGoogle Scholar
  35. Ward JM, Quander R, Devor D, Wenk ML, Spangler EF (1986) Pathology of aging female SENCAR mice used as controls in skin two-stage carcinogenesis studies. Environ Health Perspect 68: 81 - 89PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1989

Authors and Affiliations

  • Sabine Rehm

There are no affiliations available

Personalised recommendations