Classification of Neoplastic and Nonneoplastic Lesions of the Rat Mammary Gland

  • Jose Russo
  • Irma H. Russo
  • Mathew J. van Zwieten
  • Adrianne E. Rogers
  • Barry A. Gusterson
Part of the Monographs on Pathology of Laboratory Animals book series (LABORATORY)

Abstract

The rat mammary gland is one of the most widely studied and useful models of mammary carcinogenesis (Dao 1962, 1964; Gullino et al. 1975; Huggins et al. 1959; Huggins and Yang 1962; Ito 1981; Russo IH and Russo J 1978; Russo J and Russo IH 1978, 1980; Russo J et al. 1982; Shirai et al. 1981; Van Zwieten 1984; Young and Hallowes 1973). Many strains of rats develop spontaneous tumors and respond to a variety of chemical carcinogens and radiation with the development of hormone-dependent mammary tumors. The classification presented attempts to provide a working framework for diagnosing the type of lesions found in the mammary glands of rats treated with chemical carcinogens or radiation, and to clarify criteria for establishing two basic characteristics of tumors: (a) whether they are epithelial or stromal in origin, and (b) whether they are benign or malignant.

Keywords

Lactate Adenocarcinoma Hydrocarbon Adenoma Adduct 

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Copyright information

© Springer-Verlag Berlin Heidelberg 1989

Authors and Affiliations

  • Jose Russo
  • Irma H. Russo
  • Mathew J. van Zwieten
  • Adrianne E. Rogers
  • Barry A. Gusterson

There are no affiliations available

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