Abstract
Small carcinomas that develop within papillomas may be difficult to distinguish from papillomas, but fully developed carcinomas are not difficult to diagnose. These advanced carcinomas are firm nodules of more than 1 cm in diameter attached to the overlying skin which is often ulcerated over the center of the mass. They often infiltrate the underlying supporting structures, but distant metastases to the regional lymph nodes and lungs are not common. Occasionally these carcinomas consist of flat, solid masses with ulceration and crust formation in the overlying skin; this type infiltrates the underlying tissues.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Albert RE, Phillips ME, Bennett P, Burns F, Heimbach R (1969) The morphology and growth characteristics of radiation-induced epithelial skin tumors in the rat. Cancer Res 29: 658–668
Arffmann E, Hjoorne N (1979) Influence of surface lipids on skin carcinogenesis in rats. Acta Pathol Microbiol Immunol Scand [A] 87: 143–149
Cherry CP, Glucksmann A (1971) The influence of carcinogenic dosage and of sex on the induction of epitheliomas and sarcomas in the dorsal skin of rats. Br J Cancer 25: 544–564
Fare G (1966) Rat skin carcinogenesis by topical applica-tions of some azo dyes. Cancer Res 26: 2406–2408
Ghadially FN (1960) Carcinogenesis in the skin of the hedgehog. Br J Cancer 14: 212–215
Gruenstein M, Meranze DR, Shimkin MB (1966) Mammary, sebaceous and cutaneous neoplasms and leuke-mia in male Wistar rats receiving repeated gastric instillations of 3-methylcholanthrene. Cancer Res 26: 2202–2205
Hirose M, Maekawa A, Kamiya S, Odashima S (1979) Carcinogenic effect of N-ethyl-and N-amyl-N- nitrosourethanes on female Donryu rats. Gann 70: 653–662
Howell JS (1962) Skin tumors in the rat produced by 9,10-dimethyl-1,2-benzanthracene and methylcholanthrene. Br J Cancer 16: 101–109
Lennox B (1955) The production of a variety of skin tumours in rats with 2-anthramine and a comparison with the effects in mice. Br J Cancer 9: 631–639
Lever WF, Schaumberg-Lever G (1983) Histopathology of the skin, 6th edn. Lippincott, Philadelphia PA, pp 499–503
Meranze DR, Gruenstein M, Shimkin MB (1969) Effect of age and sex on the development of neoplasms in Wistar rats receiving a single intragastric instillation of 7,12-dimethylbenz(a)anthracene. Int J Cancer 4: 480–486
Rasmussen KS, Glenthoj A, Arffmann E (1983) Skin carcinogenesis in rats by 3-methylcholanthrene and 7,12-dimethylbenz(a)anthracene. Influence of dose and frequency on tumour response and its histological type. Acta Pathol Microbiol Immunol Scand [A] 91: 445–455
Rigdon RH (1952) Tumors induced by methylcholanthrene in the duck. Papilloma, squamous-cell carcinoma, and hemangioma. Arch Pathol 54: 368–377
Schweizer J, Loehrke H, Hesse B, Goerttler K (1982) 7,12-dimethylbenz(a)anthracene/12–0-tetradecanoylphorbol- 13-acetate-mediated skin tumor initiation and promotion in male Sprague-Dawley rats. Carcinogenesis 3: 785–789
Stenbäck F (1980) Skin carcinogenesis as a model system: observations on species, strain and tissue sensitivity to 7,12-dimethylbenz(a)anthracene with or without promotion from croton oil. Acta Pharmacol Toxicol (Copenh) 46: 89–97
Svoboda DJ, Reddy JK (1974) Lasiocarpine-induced, transplantable squamous cell carcinoma of rat skin. JNCI 53: 1415–1418
Takayama S (1970) Skin tumors in ACI/N rats induced by 3-methylcholanthrene and 4-dimethylaminostilbene. Gann 61: 367–371
Zabezhinski MA, Pliss GB, Okulov VB, Petrov AS (1985) Skin tumours induced by local and systemic action of N-nitroso-compounds in rats. Arch Geschwulstforsch 55: 117–122
Zackheim HS (1964a) Evolution of squamous cell carci- noma in the rat. Arch Pathol Lab Med 77: 434–444
Zackheim HS (1964b) Comparative cutaneous carcinogenesis in the rat. Differential response to the application of anthramine, methylcholanthrene, and dimethylbenzanthracene. Oncology 17: 236–246
Zackheim HS (1973) Tumours of the skin. In: Turusov VS (ed) Pathology of tumours in laboratory animals, vol 1. Tumours of the rat (pt 1). IARC, Lyon, pp 1–21 (IARC Sci Publ no 5 )
Zackheim HS, Simpson WL, Langs L (1959) Basal cell epitheliomas and other skin tumors produced in rats and mice by anthramine and methylcholanthrene. J Invest Dermatol 33: 385–402
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1989 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Hirose, M. (1989). Squamous Cell Carcinoma, Skin, Rat. In: Jones, T.C., Mohr, U., Hunt, R.D. (eds) Integument and Mammary Glands. Monographs on Pathology of Laboratory Animals. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-83749-4_4
Download citation
DOI: https://doi.org/10.1007/978-3-642-83749-4_4
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-83751-7
Online ISBN: 978-3-642-83749-4
eBook Packages: Springer Book Archive