Abstract
The tumor appears as an outgrowth from the skin surface in the form of a wart, 1–10 mm in diameter. The apical surface of the tumor can be keratinized and has either small protuberances or a cauliflower-shaped, uneven, knobby surface; fusion with adjacent papules is common. Large tumors have a dark-brown to black color due to bleeding or imbibition into the keratinized layers of dark substances (Fig.26). The surrounding skin is even and mobile in relation to the underlying tissues (Bogovsky 1979).
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsPreview
Unable to display preview. Download preview PDF.
References
Andervont HB, Edgcomb JH (1956) Responses of seven inbred strains of mice to percutaneous applications of 3-methyl cholanthrene. JNCI 17: 481–495
Argyris TS (1982) Tumor promotion by regenerative epidermal hyperplasia in mouse skin. J Cutan Pathol 9: 1–18
Balmain AR, Ramsden M, Bowden GT, Smith J (1984) Activation of the mouse cellular Harvey-ras gene in chemically induced benign skin papillomas. Nature 307: 658–660
Berenblum I (1930) Further investigations on the induction of tumours with carbon dioxide snow. Br J Exp Pathol 11: 208–211
Bogovski P (1979) Tumours of the skin. In: Turusov VS (ed) Pathology of tumours in laboratory animals, vol II. Tumours of the mouse. IARC, Lyon, pp 1–39 (IARC Sci Publ no 23 )
Boutwell RK, Bosch DK (1958) The carcinogenicity of creosote oil: its role in the induction of skin tumors in mice. Cancer Res 18: 1171–1175
DePass LR, Weil CS, Ballantyne B, Lewis SC, Losco PE, Reid JB, Simon GS (1986) Influence of housing conditions for mice on the results of a dermal oncogenicity bioassay. Fundam Appl Toxicol 7: 601–608
Frei JV, Kingsley WF (1986) Observations on chemically induced regressing tumors of mouse epidermis. JNCI 41: 1307–1313
Ghadially FN (1961) The role of the hair follicle in the origin and evolution of some cutaneous neoplasms of man and experimental animals. Cancer 14: 801–816
Harper JR, Reynolds SH, Greenkalph DA, Strickland JE, Local JC, Wyspa SH (1987) Analysis of the ras oncogene and its p21 product in chemically induced skin tumors and tumor-derived cell lines. Carcinogenesis 8: 1821–1825
Olson C (1963) Cutaneous papillomatosis in cattle and other animals. Ann NY Acad Sci 108: 1042–1056
Parkinson EK (1985) Defective responses of transformed keratinocytes to terminal differentiation stimuli. Their role in epidermal tumour promotion by phorbol esters and by deep skin wounding. Br J Cancer 52: 479–493
Pelling JC, Ernst SM, Strawhecker JM, Johnson JA, Nairn RS, Slaga TJ (1986) Elevated expression of Haras is an early event in two-stage skin carcinogenesis in SENCAR mice. Carcinogenesis 7: 1599–1602
Raick AN (1974) Cell proliferation and promoting action in skin carcinogenesis. Cancer Res 34: 920–926
Rice JM, Anderson LM (1986) Sebaceous adenomas with associated epidermal hyperplasia and papilloma formation as a major type of tumor induced in mouse skin by high doses of carcinogens. Cancer Lett 33: 295–306
Roop DR, Lowy DR, Tambourin PE, Strickland J, Harper JR, Balaschak M, Spangler EF, Yuspa SH (1986) An activated Harvey ras oncogene produces benign tumours on mouse epidermal tissue. Nature 323: 822–824
Shubik P, Baserga R, Ritchie AC (1953) The life and progression of induced skin tumours in mice. Br J Cancer 7: 342–351
Slaga TJ (1983) Overview of tumor promotion in animals Environ Health Perspect 50: 3–14
Slaga TJ, Nesnow S (1985) SENCAR mouse skin tumori-genesis. In: Milman HA, Weisburger EK (eds) Handbook of carcinogen testing. Noyes, Park Ridge NJ, pp 230–250
Squire RA, Goodman DG, Valerio MG, Fredrickson T, Strandberg JD, Levitt MH, Lingeman CH, Harshbarger JC, Dawe CJ (1978) Tumors. In: Benirschke K, Garner FM, Jones TC (eds) Pathology of laboratory animals, vol 2. Springer, Berlin Heidelberg New York, pp 1051–1283
Stenbäck F (1980) Skin carcinogenesis as a model system: observations on species, strain and tissue sensitivity to 7,12-dimethylbenz(a)anthracene with and without promotion from croton oil. Acta Pharmacol Toxicol (Copenh) 46: 89–97
Turusov VS, Day N, Andrianov L, Jain D (1971) Influence of dose on skin tumors induced in mice by single application of 7,12-dimethylbenz(a)anthracene. JNCI 47: 105–111
Weisburger JH, Weisburger EK (1967) Tests for chemical carcinogenesis. In: Busch H (ed) Methods in cancer research, vol 1. Academic, New York, pp 307–398
Yuspa SH (1984) Mechanisms of initiation and promotion in mouse epidermis. In: Borzsonyi M, Lapis K, Day NE, Yamasaki Y (eds) Models, mechanisms and etiology of tumor promotion. Oxford University Press, pp 191–204 (IARC Sci Publ no 56 )
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1989 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Hasegawa, R., Sato, H., Miyakawa, Y. (1989). Squamous Cell Papilloma, Skin, Mouse. In: Jones, T.C., Mohr, U., Hunt, R.D. (eds) Integument and Mammary Glands. Monographs on Pathology of Laboratory Animals. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-83749-4_3
Download citation
DOI: https://doi.org/10.1007/978-3-642-83749-4_3
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-83751-7
Online ISBN: 978-3-642-83749-4
eBook Packages: Springer Book Archive