Advertisement

Squamous Cell Papilloma, Skin, Mouse

  • Ryohei Hasegawa
  • Hidetaka Sato
  • Yoshifumi Miyakawa
Part of the Monographs on Pathology of Laboratory Animals book series (LABORATORY)

Abstract

The tumor appears as an outgrowth from the skin surface in the form of a wart, 1–10 mm in diameter. The apical surface of the tumor can be keratinized and has either small protuberances or a cauliflower-shaped, uneven, knobby surface; fusion with adjacent papules is common. Large tumors have a dark-brown to black color due to bleeding or imbibition into the keratinized layers of dark substances (Fig.26). The surrounding skin is even and mobile in relation to the under­lying tissues (Bogovsky 1979).

Synonyms

Epidermoid papilloma fibroepithelioma fibroepithelial papilloma sessile papilloma 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Andervont HB, Edgcomb JH (1956) Responses of seven inbred strains of mice to percutaneous applications of 3-methyl cholanthrene. JNCI 17: 481–495PubMedGoogle Scholar
  2. Argyris TS (1982) Tumor promotion by regenerative epidermal hyperplasia in mouse skin. J Cutan Pathol 9: 1–18PubMedCrossRefGoogle Scholar
  3. Balmain AR, Ramsden M, Bowden GT, Smith J (1984) Activation of the mouse cellular Harvey-ras gene in chemically induced benign skin papillomas. Nature 307: 658–660PubMedCrossRefGoogle Scholar
  4. Berenblum I (1930) Further investigations on the induction of tumours with carbon dioxide snow. Br J Exp Pathol 11: 208–211Google Scholar
  5. Bogovski P (1979) Tumours of the skin. In: Turusov VS (ed) Pathology of tumours in laboratory animals, vol II. Tumours of the mouse. IARC, Lyon, pp 1–39 (IARC Sci Publ no 23 )Google Scholar
  6. Boutwell RK, Bosch DK (1958) The carcinogenicity of creosote oil: its role in the induction of skin tumors in mice. Cancer Res 18: 1171–1175PubMedGoogle Scholar
  7. DePass LR, Weil CS, Ballantyne B, Lewis SC, Losco PE, Reid JB, Simon GS (1986) Influence of housing conditions for mice on the results of a dermal oncogenicity bioassay. Fundam Appl Toxicol 7: 601–608PubMedCrossRefGoogle Scholar
  8. Frei JV, Kingsley WF (1986) Observations on chemically induced regressing tumors of mouse epidermis. JNCI 41: 1307–1313Google Scholar
  9. Ghadially FN (1961) The role of the hair follicle in the origin and evolution of some cutaneous neoplasms of man and experimental animals. Cancer 14: 801–816PubMedCrossRefGoogle Scholar
  10. Harper JR, Reynolds SH, Greenkalph DA, Strickland JE, Local JC, Wyspa SH (1987) Analysis of the ras oncogene and its p21 product in chemically induced skin tumors and tumor-derived cell lines. Carcinogenesis 8: 1821–1825PubMedCrossRefGoogle Scholar
  11. Olson C (1963) Cutaneous papillomatosis in cattle and other animals. Ann NY Acad Sci 108: 1042–1056PubMedCrossRefGoogle Scholar
  12. Parkinson EK (1985) Defective responses of transformed keratinocytes to terminal differentiation stimuli. Their role in epidermal tumour promotion by phorbol esters and by deep skin wounding. Br J Cancer 52: 479–493PubMedCrossRefGoogle Scholar
  13. Pelling JC, Ernst SM, Strawhecker JM, Johnson JA, Nairn RS, Slaga TJ (1986) Elevated expression of Haras is an early event in two-stage skin carcinogenesis in SENCAR mice. Carcinogenesis 7: 1599–1602PubMedCrossRefGoogle Scholar
  14. Raick AN (1974) Cell proliferation and promoting action in skin carcinogenesis. Cancer Res 34: 920–926PubMedGoogle Scholar
  15. Rice JM, Anderson LM (1986) Sebaceous adenomas with associated epidermal hyperplasia and papilloma formation as a major type of tumor induced in mouse skin by high doses of carcinogens. Cancer Lett 33: 295–306PubMedCrossRefGoogle Scholar
  16. Roop DR, Lowy DR, Tambourin PE, Strickland J, Harper JR, Balaschak M, Spangler EF, Yuspa SH (1986) An activated Harvey ras oncogene produces benign tumours on mouse epidermal tissue. Nature 323: 822–824PubMedCrossRefGoogle Scholar
  17. Shubik P, Baserga R, Ritchie AC (1953) The life and progression of induced skin tumours in mice. Br J Cancer 7: 342–351PubMedCrossRefGoogle Scholar
  18. Slaga TJ (1983) Overview of tumor promotion in animals Environ Health Perspect 50: 3–14Google Scholar
  19. Slaga TJ, Nesnow S (1985) SENCAR mouse skin tumori-genesis. In: Milman HA, Weisburger EK (eds) Handbook of carcinogen testing. Noyes, Park Ridge NJ, pp 230–250Google Scholar
  20. Squire RA, Goodman DG, Valerio MG, Fredrickson T, Strandberg JD, Levitt MH, Lingeman CH, Harshbarger JC, Dawe CJ (1978) Tumors. In: Benirschke K, Garner FM, Jones TC (eds) Pathology of laboratory animals, vol 2. Springer, Berlin Heidelberg New York, pp 1051–1283Google Scholar
  21. Stenbäck F (1980) Skin carcinogenesis as a model system: observations on species, strain and tissue sensitivity to 7,12-dimethylbenz(a)anthracene with and without promotion from croton oil. Acta Pharmacol Toxicol (Copenh) 46: 89–97CrossRefGoogle Scholar
  22. Turusov VS, Day N, Andrianov L, Jain D (1971) Influence of dose on skin tumors induced in mice by single application of 7,12-dimethylbenz(a)anthracene. JNCI 47: 105–111PubMedGoogle Scholar
  23. Weisburger JH, Weisburger EK (1967) Tests for chemical carcinogenesis. In: Busch H (ed) Methods in cancer research, vol 1. Academic, New York, pp 307–398Google Scholar
  24. Yuspa SH (1984) Mechanisms of initiation and promotion in mouse epidermis. In: Borzsonyi M, Lapis K, Day NE, Yamasaki Y (eds) Models, mechanisms and etiology of tumor promotion. Oxford University Press, pp 191–204 (IARC Sci Publ no 56 )Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1989

Authors and Affiliations

  • Ryohei Hasegawa
  • Hidetaka Sato
  • Yoshifumi Miyakawa

There are no affiliations available

Personalised recommendations