New Approaches and Diagnostic Techniques in Dermatopathology
A variety of specialized techniques are available to aid the interpretation and diagnosis of human cutaneous diseases. Neoplastic or inflammatory skin disorders may be evaluated by application of electron microscopy, immunoperoxidase, immunofluorescence, and most recently, nucleic acid hybridization probe analysis (Murphy et al. 1982; Beutner et al. 1987; Kahn et al. 1986; Fenoglio-Preiser and Willman 1987). This chapter will review the microscopic features and differential diagnoses of a number of human cutaneous lesions in which application of one or more special diagnostic techniques may contribute to establishing a correct diagnosis.
KeywordsBullous Pemphigoid Epidermolysis Bullosa Dermal Papilla Eosinophilic Granuloma Dermatitis Herpetiformis
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- Beutner EH, Chorzelski TP, Jablonska S (1987) Clinical significance of immunofluorescence tests of sera and skin in bullous diseases: a cooperative study. In: Beutner EH, Chorzelski TP, Kumar V (eds). Immunopathology of the skin, 3rd edn. Wiley, New York, pp 177–205Google Scholar
- Enzinger FM (1979) Question: are atypical fibroxanthoma and malignant fibrous histiocytoma related pathologic processes? Am J Dermatopathol 1: 185Google Scholar
- Murphy GF, Dickersin GR, Harrist TJ, Mihm MC (1982) The role of diagnostic electron microscopy in dermatology. In: Moschella S (ed) Dermatology update. Elsevier, New York, pp 355–384Google Scholar
- Yasuhara T, Ishikawa O, Nakajima T, Araki K, Tachibana S (1979) The studies on the active peptide on smooth muscle in the skin of Rana rugosa. II. The structure of ranatensin-R, the new ranatensin analogue, and granuliberi-R, the new mast cell degranulating peptide. Chem Pharm Bull (Tokyo) 27: 492–498CrossRefGoogle Scholar