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Die Bedeutung von Onkogenen für Entstehung und Progression menschlicher Tumoren

  • Conference paper
Molekularbiologische Methoden in der Diagnostik

Part of the book series: Zusammenarbeit von Klinik und Klinischer Chemie ((ZUSAMMENARBEIT))

  • 43 Accesses

Zusammenfassung

Unter retroviralen Onkogenen versteht man Gensequenzen, die in das replikative Genom von Retroviren integriert sind. Die retroviralen Onkogene (v-onc) sind für die transformierende Wirkung der Viren essentiell. Retrovirale Onkogene sind normalen Genen des Menschen homolog, die daher auch als zelluläre Onkogene (c-onc) oder Protoonkogene bezeichnet werden. Einige der Protoonkogene kodieren für Proteine, die eine zentrale Bedeutung für die Regulation von Wachstum und Differenzierung besitzen. Die transformierende Wirkung retroviraler Onkogene und der Bezug retroviraler und zellulärer Onkogene zur Wachstumsregulation haben dazu geführt, Protoonkogenen einen zentralen Stellenwert für Entstehung und Progression maligner Tumoren des Menschen zuzuweisen.

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Authors
  1. C. Wagener
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Editor information

Editors and Affiliations

  1. Forschung Diagnostica, E. Merck, Darmstadt, Deutschland

    Hermann Lang

  2. Institut für Klinische Chemie, Städtisches Krankenhaus, München-Bogenhausen, Deutschland

    Walter G. Guder

  3. Abteilung Biotechnologie, Dechema-Institut, Frankfurt-Main, Deutschland

    Alber J. Driesel

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© 1989 Springer-Verlag Berlin Heidelberg

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Wagener, C. (1989). Die Bedeutung von Onkogenen für Entstehung und Progression menschlicher Tumoren. In: Lang, H., Guder, W.G., Driesel, A.J. (eds) Molekularbiologische Methoden in der Diagnostik. Zusammenarbeit von Klinik und Klinischer Chemie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-83748-7_9

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  • DOI: https://doi.org/10.1007/978-3-642-83748-7_9

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-50966-0

  • Online ISBN: 978-3-642-83748-7

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