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Erythropoietin Production in Malignancy

  • H. Johannsen
  • A. J. Gross
  • W. Jelkmann

Abstract

The glycoprotein hormone erythropoietin stimulates the proliferation and differentiation of erythrocytic progenitors in bone marrow. Erythropoiesis counterbalances the permanent loss of aged red blood cells. The red cell mass, hemoglobin concentration, and oxygen transport capacity of the blood are relatively constant under physiological conditions. The production of erythropoietin is augmented following phlebotomy, until the mass of red blood cells is restored.

Keywords

Chronic Myelogenous Leukemia Acute Myelogenous Leukemia Human Renal Carcinoma Cell Erythropoietin Level Acute Myelogenous Leukemia Patient 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Altaffer LFW, Chenault OW (1979) Paraneoplastic endocrinopathies associated with renal tumors. J Urol 122: 573–577PubMedGoogle Scholar
  2. 2.
    Anagnostou A, Chawla MS, Pololi L, Fried W (1979) Determination of plasma erythropoietin levels. Cancer 44: 1014–1016PubMedCrossRefGoogle Scholar
  3. 3.
    Bennett JM, Catovsky D, Daniel MT, Flandrin G, Galton DAG, Gralnick HR, Sultan C (1976) Proposals for the classification of the acute leukaemia. Br J Haematol 33: 451–458PubMedCrossRefGoogle Scholar
  4. 4.
    Böhling T, Haltia M, Rosenlöf K, Fyhrquist F (1987) Erythropoietin in capillary hemangioblastoma. Acta Neuropathol (Berl) 74: 324–328CrossRefGoogle Scholar
  5. 5.
    Bruneval P, da Silva JL, Lacombe C, Salzmann JL, Tambourin P, Varet B, Camilleri JP, Bariety J (1988) Erythropoietin synthesis in the anemic mouse kidney, as observed by morphological techniques. Lübeck Conference on the Pathophysiology and Pharmacology of Erythropoietin, Lübeck, FRG, 25 JuneGoogle Scholar
  6. 6.
    Burns ER, Schulman IC, Murphy MJ (1982) Hematologic manifestations and etiology of atrial myxoma. Am J Med Sci 284: 17–22PubMedCrossRefGoogle Scholar
  7. 7.
    Cartwright GE (1966) The anemia of chronic disorders. Semin Hematol 3: 351–375PubMedGoogle Scholar
  8. 8.
    Cox R, Musial T, Gyde OHB (1986) Reduced erythropoietin levels as a cause of anaemia in patients with lung cancer. Eur J Cancer Clin Oncol 22: 511–514PubMedCrossRefGoogle Scholar
  9. 9.
    Dainiak N, Kulkarni V, Howard D, Kalmanti M, Dewey MC, Hoffman R (1983) Mechanisms of abnormal erythropoiesis in malignancy. Cancer 51: 1101–1106PubMedCrossRefGoogle Scholar
  10. 10.
    De Gowin RL, Gibson DP (1979) Erythropoietin and the anemia of mice bearing extramedullary tumor. J Lab Clin Med 94: 303–311Google Scholar
  11. 11.
    Douglas SW, Adamson JW (1975) The anemia of chronic disorders: studies of marrow regulation and iron metabolism. Blood 45: 55–65PubMedGoogle Scholar
  12. 12.
    Eaves AC, Eaves CJ (1979) Abnormalities in the erythroid progenitor compartments in patients with chronic myelogenous leukemia (CML). Exp Hematol 7 [Suppl 5]: 65–75PubMedGoogle Scholar
  13. 13.
    Eaves AC, Eaves CJ (1984) Erythropoiesis in culture. Clin Haematol 13: 371–391PubMedGoogle Scholar
  14. 14.
    Eldor A, Even-Paz Z, Polliack A (1976) Erythrocytosis associated with multiple cutaneous leiomyomata: report of a case with demonstration of erythropoietic activity in the tumour. Scand J Haematol 16: 245–249PubMedCrossRefGoogle Scholar
  15. 15.
    Firat D, Banzon J (1971) Erythropoietic effect of plasma from patients with advanced cancer. Cancer Res 31: 1353–1359Google Scholar
  16. 16.
    Fried W, Ward HP, Hopeman AR (1968) Leiomyoma and erythrocytosis: a tumor producing a factor which increases erythropoietin production. Report of a case. Blood 31: 813–816PubMedGoogle Scholar
  17. 17.
    Fukushima Y, Miura I, Takahashi T, Fukuda M, Yoshida K, Yamaguchi A, Miura AB (1984) Serum erythropoietin (ESF) levels and erythroid progenitors (CFU-Es) of patients with chronic myeloproliferative disorders. Tohoku J Exp Med 142: 399–407PubMedCrossRefGoogle Scholar
  18. 18.
    Gabuzda TG, Shute HE, Erslev AJ (1969) Regulation of erythropoiesis in erythroleukemia. Arch Intern Med 123: 60–63PubMedCrossRefGoogle Scholar
  19. 19.
    Gallagher NI, Donati RM (1968) Inappropriate erythropoietin elaboration. Ann NY Acad Sci 149: 528–538PubMedCrossRefGoogle Scholar
  20. 20.
    Goldberg MA, Glass GA, Cunningham JM, Bunn HF (1987) The regulated expression of erythropoietin by two human hepatoma cell lines. Proc Natl Acad Sci USA 84: 7972–7976PubMedCrossRefGoogle Scholar
  21. 21.
    Goldman JM, Shiota F, Th’ng KH, Orchard KH (1980) Circulating granulocytic and erythroid progenitor cells in chronic granulocytic leukaemia. Br J Haematol 46: 7–13PubMedCrossRefGoogle Scholar
  22. 22.
    Gruber DF, Zucali JR, Wleklinski J, LaRussa V, Mirand EA (1977) Temporal transition in the site of rat erythropoietin production. Exp Hematol 5: 399–407PubMedGoogle Scholar
  23. 23.
    Gruber DF, Zucali JR, Mirand EA (1977) Identification of erythropoietin producing cells in fetal mouse liver cultures. Exp Hematol 5: 392–398PubMedGoogle Scholar
  24. 24.
    Hagiwara M, Chen IL, McGonigle R, Beckman B, Kasten FH, Fisher JW (1984) Erythropoietin production in a primary culture of human renal carcinoma cells maintained in nude mice. Blood 63: 828–835PubMedGoogle Scholar
  25. 25.
    Hammond D, Winnick S (1974) Paraneoplastic erythrocytosis and extopic erythropoietins. Ann NY Acad Sci 230: 219–227PubMedCrossRefGoogle Scholar
  26. 26.
    Hankins WD, Schooley J, Eastment C (1986) Erythropietin, an autocrine regulator? Serumfree production of erythropoietin by cloned erythroid cell lines. Blood 68: 263–268PubMedGoogle Scholar
  27. 27.
    Hennessy TG, Stern WE, Herrick SE (1967) Cerebellar hemangioblastoma: erythropoietic activity by radioiron assay. J Nucl Med 8: 601–606PubMedGoogle Scholar
  28. 28.
    Hoffman R, Zanjani ED (1978) Erythropoietin dependent erythropoiesis during the erythroblastic phase of juvenile chronic granulocytic leukaemia. Br J Haematol 38: 511–516PubMedCrossRefGoogle Scholar
  29. 29.
    Hoffman R, Kopel S, Hsu SD, Dainiak N, Zanjani ED (1978) T cell chronic lymphocytic leukemia: presence in bone marrow and peripheral blood of cells that suppress erythropoiesis in vitro. Blood 52: 255–260PubMedGoogle Scholar
  30. 30.
    Jankovic GM, Ristic MS, Pavlovic-Kentera V (1986) Cerebellar hemangioblastoma with erythropoietin in cerebrospinal fluid. Scand J Haematol 36: 511–514PubMedCrossRefGoogle Scholar
  31. 31.
    Jeffreys RV, Napier JAF, Reynolds SH (1982) Erythropoietin levels in posterior fossa haemangioblastoma. J Neurol Neurosurg Psychiatry 45: 264–266PubMedCrossRefGoogle Scholar
  32. 32.
    Jelkmann W (1986) Renal erythropoietin: properties and production. Rev Physiol Biochem Pharmacol 104: 139–215PubMedCrossRefGoogle Scholar
  33. 33.
    Johannsen H, Jelkmann W, Wiedemann G, Otte M, Wagner T (1989) Erythropoietin/haemoglobin relationship in leukaemia and ulcerative colitis. Eur J Haematol (in press)Google Scholar
  34. 34.
    Katsuoko Y, McGonigle R, Rege AB, Beckman B, Fisher JW (1983) Erythropoietin production in human renal carcinoma cells passaged in nude mice and in tissue culture. Gann 74: 534–541Google Scholar
  35. 35.
    Kazal LA, Erslev AJ (1975) Erythropoietin production in renal tumors. Ann Clin Lab Sci 5: 98–109PubMedGoogle Scholar
  36. 36.
    Kenny GM, Mirand EA, Staubitz WJ, Allen JE, Trudel PJ, Murphy GP (1970) Erythropoietin levels in Wilms’ tumor patients. J Urol 104: 758–761PubMedGoogle Scholar
  37. 37.
    Kew MC, Fisher JW (1986) Serum erythropoietin concentrations in patients with hepatocellular carcinoma. Cancer 58: 2485–2488PubMedCrossRefGoogle Scholar
  38. 38.
    Kojima S, Mimaya J, Tonouchi T, Yokochi T, Kajitani S (1987) Erythropoiesis during an erythroblastic phase of chronic myeloproliferative disorder associated with monosomy 7. Br J Haematol 65: 391–394PubMedCrossRefGoogle Scholar
  39. 39.
    Koury ST, Bondurant MC, Koury MJ (1988) Localization of erythropoietin synthesizing cells in murine kidneys by in situ hybridization. Blood 71: 524–527PubMedGoogle Scholar
  40. 40.
    Kurnick JE, Ward HP, Pickett JC (1972) Mechanism of the anemia of chronic disorders. Arch Intern Med 130: 323–326PubMedCrossRefGoogle Scholar
  41. 41.
    Kvarstein B, Lindemann R, Mathisen W (1973) Renal carcinoma with increased erythropoietin production and secondary polycythemia. Scand J Urol Nephrol 7: 178–180PubMedCrossRefGoogle Scholar
  42. 42.
    Lan S, McCulloch EA, Till JA (1978) Cytodifferentiation in the acute myeloblastic leukemias of man. J Natl Cancer Inst 60: 265–269PubMedGoogle Scholar
  43. 43.
    McFadzean AJS, Todd D, Tso SC (1967) Erythrocytosis associated with hepatocellular carcinoma. Blood 29: 808–811PubMedGoogle Scholar
  44. 44.
    Lacombe C, Da Silva JL, Bruneval P, Fournier JG, Wendling F, Casadevall N, Camilleri JP, Bariety J, Varet B, Tambourin P (1988) Peritubular cells are the site of erythropietin synthesis in the murine hypoxic kidney. J Clin Invest 81: 620–623PubMedCrossRefGoogle Scholar
  45. 45.
    Morse EE (1979) Consequences of erythropoietin production by neoplasms. Ann Clin Lab Sci 9: 116–120PubMedGoogle Scholar
  46. 46.
    Murphy GP, Mirand EA (1971) Erythropoietin alterations in human renal disease. Rev Surg 28: 236–245PubMedGoogle Scholar
  47. 47.
    Murphy GP, Mirand EA, Johnston GS, Gibbons RP, Jones RL, Scott WW (1967) Erythropoietin release associated with Wilms’ tumor. Johns Hopkins Med J 120: 26–32PubMedGoogle Scholar
  48. 48.
    Murphy GP, Mirand EA, Staubitz WJ (1976) The value of erythropoietin assay in the follow-up of Wilms’ tumor patients. Oncology 33: 154–156PubMedCrossRefGoogle Scholar
  49. 49.
    Naets JP, Wittek M, Delwiche F, Kram I (1977) Polycythaemia and erythropoietin producing uterine fibromyoma. Scand J Haematol 19: 75–78PubMedCrossRefGoogle Scholar
  50. 50.
    Neumann HPH (1987) Basic criteria for clinical diagnosis and genetic counselling in von Hippel-Lindau syndrome. VASA 16: 220–226PubMedGoogle Scholar
  51. 51.
    Nielsen OJ, Schuster SJ, Kaufman R, Erslev AJ, Caro J (1987) Regulation of erythropoietin production in a human hepatoblastoma cell line. Blood 70: 1904–1909PubMedGoogle Scholar
  52. 52.
    Okabe T, Urabe A, Kato T, Chiba S, Takaku F (1985) Production of erythropoietin-like activity by human renal and hepatic carcinomas in cell culture. Cancer 55: 1918–1923PubMedCrossRefGoogle Scholar
  53. 53.
    Ossias AL, Zanjani ED, Zalusky R, Estren S, Wasserman LR (1973) Case report: studies on the mechanism of erythrocytosis associated with a uterine fibromyoma. Br J Haematol 25: 179–185PubMedCrossRefGoogle Scholar
  54. 54.
    Pavlovic-Kentera V, Stefanovic S, Milenkovic P, Jancic M, Biljanovic-Paunovic L (1976) Erythropoietin level in patients with acute leukaemia. Haematologia (Budap) 10: 455–462Google Scholar
  55. 55.
    Roodman GD (1987) Mechanisms of erythroid suppression in the anemia of chronic disease. Blood Cells 13: 171–184PubMedGoogle Scholar
  56. 56.
    Schooley JC, Kullgren B, Allison AC (1987) Inhibition by interleukin-1 of the action of erythropoietin on erythroid precursors and its possible role in the pathogenesis of hypoplastic anaemias. Br J Haematol 67: 11–17PubMedCrossRefGoogle Scholar
  57. 57.
    Schreuder WO, Ting WC, Smith S, Jacobs A (1984) Testosterone, erythropoietin and anaemia in patients with disseminated bronchial cancer. Br J Haematol 57: 521–526PubMedCrossRefGoogle Scholar
  58. 58.
    Shalet MF, Holder TM, Walters TR (1967) Erythropoietin-producing Wilms’ tumor. J Pediatr 70: 615–617PubMedCrossRefGoogle Scholar
  59. 59.
    Shalhoub RJ, Rajan U, Kim VV, Goldwasser E, Kark JA, Antoniou LD (1982) Erythrocytosis in patients on long-term hemodialysis. Ann Intern Med 97: 686–690PubMedGoogle Scholar
  60. 60.
    Sherwood JB, Goldwasser E (1976) Erythropoietin production by human renal carcinoma cells in culture. Endocrinology 99: 504–510PubMedCrossRefGoogle Scholar
  61. 61.
    Slee PHTJ, Blusse A, Brutel de la Riviere G, den Ottolander GJ (1978) Erythrocytosis and Wilms’ tumour. Scand J Haematol 21: 287–291PubMedCrossRefGoogle Scholar
  62. 62.
    Sufrin G, Mirand EA, Moore RH, Chu TM, Murphy GP (1977) Hormones in renal cancer. J Urol 117: 433–438PubMedGoogle Scholar
  63. 63.
    Sytkowski AJ, Bicknell KA, Smith GM, Garcia JF (1984) Secretion of erythropoietin-like acitivity by clones of human renal carcinoma cell line GKA. Cancer Res 44: 51–54PubMedGoogle Scholar
  64. 64.
    Thorling EB (1965) Erythropoietin in serum from patients with leucosis assays in starved rats. Scand J Haematol 2: 36–51PubMedCrossRefGoogle Scholar
  65. 65.
    Thorling EB (1972) Paraneoplastic erythrocytosis and inappropriate erythropoietin production. Scand J Haematol 17: 1–166Google Scholar
  66. 66.
    Toogood IRG, Ekert H, Smith PJ (1978) Controlled study of hypertransfusion during remission induction in childhood acute lymphocytic leukaemia. Lancet ii: 862–864CrossRefGoogle Scholar
  67. 67.
    Toyama K, Fujiyama N, Suzuki H, Chen TP, Tamaoki N, Ueyama Y (1979) Erythropoietin levels in the course of a patient with erythropoietin-producing renal cell carcinoma and transplantation of this tumor in nude mice. Blood 54: 245–253PubMedGoogle Scholar
  68. 68.
    Waldmann TA, Bradley JE (1961) Polycythemia secondary to a pheochromocytoma with production of an erythropoiesis stimulating factor by the tumor. Proc Soc Exp Biol Med 108: 425–427PubMedGoogle Scholar
  69. 69.
    Waldmann TA, Rosse W (1964) Tumors producing erythropoiesis-stimulating factors. In: Sundermann FW, Sundermann FW (eds) Hemoglobin, its precursors and metabolites. Lippincott, Philadelphia, pp 276–280Google Scholar
  70. 70.
    Ward HP, Kurnick JE, Pisarczyk MJ (1971) Serum level of erythropoietin in anemias associated with chronic infection, malignancy, and primary hematopoietic disease. J Clin Invest 50: 332–335PubMedCrossRefGoogle Scholar
  71. 71.
    Wrigley PFM, Malpas JS, Turnbull AL, Jenkins GC, McArt A (1971) Secondary polycythaemia due to a uterine fibromyoma producing erythropoietin. Br J Haematol 21: 551–555PubMedCrossRefGoogle Scholar
  72. 72.
    Zucker S, Friedman S, Lysik RM (1974) Bone marrow erythropoiesis in the anemia of infection, inflammation, and malignancy. J Clin Invest 53: 1132–1138PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1989

Authors and Affiliations

  • H. Johannsen
  • A. J. Gross
  • W. Jelkmann

There are no affiliations available

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