Abstract
The depressed erythropoiesis of uremic anemia is consequent to the reduced proliferation and differentiation of erythroid stem cells, which are due to the deficient production of erythropoietin (EPO) by the kidney [1–3]. This is confirmed by the very recent results concerning recombinant human erythropoietin (rHuEPO) use in uremic dialysis patients, which showed that intravenous administration of this hormone leads to a significant improvement in erythropoiesis [4–6].
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Lai PH, Everett R, Wang FF, Azokawa T, Goldwasser E (1986) Structural characterization of human erythropoietin. J Biol Chem 261: 3116–3121
Jacobs K, Shoemaker C, Rudersdorf R (1985) Isolation and characterization of genomic and DNA clones of human erythropoietin. Nature 313: 806–810
Lin FK, Suggs S, Lin CH (1986) Cloning and expression of the human erythropoietin gene. Proc Natl. Acad Sci USA 82: 7580–7584
Winearls CG, Pippard MJ, Downing MR, Oliver DO, Reid C, Cotes PM (1986) Effect of human erythropoietin derived from recombinant DNA on the anemia of patients maintained by chronic hemodialysis. Lancet 22: 1175–1178
Eschbach JW, Egrie JC, Downing MR, Browne JK, Adamson JW (1987) Correction of the anemia of the end stage renal disease with recombinant human erythropoietin. N Engl J Med 316: 73–78
Dessypris EN, Gleaton JH, Armstrong OL (1987) Effect of human recombinant erythropoietin on human marrow megakaryocyte colony formation in vitro. Br J Haematol 65: 265–269
Douer D, Koeffler HP (1982) Retinoic acid enhances growth of human early erythroid progenitor cells in vitro. J Clin Invest 69: 1039–1041
Orfanos CE, Ehlert R, Gollnick H (1987) The retinoids. A review of their clinical pharmacology and therapeutic use. Drugs 34: 411–514
Iscove NN (1977) The role of the erythropoietin in regulation of population size and cell cycling of early and late erythroid precursors in mouse bone marrow. Cell Tissue Kinet 10: 323–334
Doner D, Koeffler HP (1982) Retinoic acid enhances colony stimulating factor induced clonal growth of normal human myeloid progenitor cells in vitro. Exp Cell Res 138: 193–198
Kerndrup G, Bendix-Hausen K, Pedersen B, Ellegaard J, Hokland P (1986) Primary myelodysplastic syndrome: treatment of 6 patients with 13-cis retinoic acid. Scand J Haematol 36(S45): 128–132
Koeffler HP (1983) Induction of differentiation of human acute myelogenous leukemia cells: therapeutic implications. Blood 62: 709–721
Kerndrup G, Bendix-Hausen K, Pedersen B, Ellegaard J, Hokland P (1987) 13-cis retinoic acid treatment of myelodysplastic syndromes. Leuk Res 11: 7–16
Fisher JW, Lajtha LG, Buttoo AS, Porteous DD (1965) Direct effects of erythropoietin on the bone marrow of the isolated perfused hind limbs of rabbit. Br J Haematol 11: 342–349
Stohlman F Jr (1971) Erythropoietin and erythroid cell kinetics. In: Fisher JW (ed) Kidney hormones. Academic, New York, p 331
Erslev AJ (1987) Erythropoietin coming of age. N Engl J Med 316: 101–103
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1989 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Carozzi, S., Nasini, M.G., Lamperi, S. (1989). Recombinant Human Erythropoietin and CIS-Retinoic Acid Therapy of Anemia in Hemodialysis and Peritoneal Dialysis Patients. In: Jelkmann, W., Gross, A.J. (eds) Erythropoietin. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-83745-6_14
Download citation
DOI: https://doi.org/10.1007/978-3-642-83745-6_14
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-83747-0
Online ISBN: 978-3-642-83745-6
eBook Packages: Springer Book Archive