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Introduction: Advances in Erythropoietin Research

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Erythropoietin

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Abstract

New blood cells are permanently generated from stem cells in the hemopoietically active bone marrow. Pluripotent hematopoietic stem cells have the capacity to selfreplicate and to produce progeny committed to any of the different lineages of blood cells. Little is known about the mechanisms which control the differentiation of the pluripotent stem cells. The glycoprotein hormone erythropoietin stimulates the proliferation and differentiation of progenitor cells committed to the erythrocytic lineage (Fig. 1).

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References

  1. Annable L, Cotes PM, Mussett MV (1972) The second international reference preparation of erythropoietin, human, urinary, for bioassay. Bull WHO 47: 99–112

    PubMed  CAS  Google Scholar 

  2. Beru N, McDonald J, Lacombe C, Goldwasser E (1986) Expression of the erythropoietin gene. Mol Cell Biol 6: 2571–2575

    PubMed  CAS  Google Scholar 

  3. Bondurant MC, Koury MJ (1986) Anemia induces accumulation of erythropoietin mRNA in the kidney and liver. Mol Cell Biol 6: 2731–2733

    PubMed  CAS  Google Scholar 

  4. Carnot P, Deflandre C (1906) Sur l’activité hémopoïétique des différents organes au cours de la régénération du sang. CR Acad Sci Paris 143: 432–435

    Google Scholar 

  5. Cotes PM (1982) Immunoreactive erythropoietin in serum. Br J Haematol 50: 427–438

    Article  PubMed  CAS  Google Scholar 

  6. Cotes PM, Bangham DR (1961) Bio-assay of erythropoietin in mice made polycythaemic by exposure to air at a reduced pressure. Nature 191: 1065–1067

    Article  PubMed  CAS  Google Scholar 

  7. Davis JM, Arakawa T, Strickland TW, Yphantis DA (1987) Characterization of recombinant human erythropoietin produced in Chinese hamster ovary cells. Biochemistry 26: 2633–2638

    Article  PubMed  CAS  Google Scholar 

  8. Egrie JC, Strickland TW, Lane J, Aoki K, Cohen AM, Smalling R, Trail G, Lin FK, Browne JK, Hines DK (1986) Characterization and biological effects of recombinant human erythropoietin. Immunobiology 172: 213–224

    Article  PubMed  CAS  Google Scholar 

  9. Erslev A (1953) Humoral regulation of red cell production. Blood 8: 349–357

    PubMed  CAS  Google Scholar 

  10. Erslev AJ (1974) In vitro production of erythropoietin by kidneys perfused with a serum-free solution. Blood 44: 77–85

    PubMed  CAS  Google Scholar 

  11. Erslev AJ (1980) Blood and mountains. In: Wintrobe MM (ed) Blood, pure and eloquent. McGraw-Hill, New York, pp 257–280

    Google Scholar 

  12. Eschbach JW, Egrie JC, Downing MR, Browne JK, Adamson JW (1987) Correction of the anemia of end-stage renal disease with recombinant human erythropoietin. N Engl J Med 316: 73–78

    Article  PubMed  CAS  Google Scholar 

  13. Fisher JW, Birdwell BJ (1961) The production of an erythropoietic factor by the in situ perfused kidney. Acta Haematol 26: 224–232

    Article  PubMed  CAS  Google Scholar 

  14. Fried W (1972) The liver as a source of extrarenal erythropoietin production. Blood 40: 671–677

    PubMed  CAS  Google Scholar 

  15. Garcia JF, Sherwood J, Goldwasser E (1979) Radioimmunoassay of erythropoietin. Blood Cells 5: 405–419

    PubMed  CAS  Google Scholar 

  16. Goldberg MA, Dunning SP, Bunn HF (1988) Regulation of the erythropoietin gene: Evidence that the oxygen sensor is a heme protein. Science 242: 1412–1415

    Article  PubMed  CAS  Google Scholar 

  17. Gordon AS, Cooper GW, Zanjani ED (1967) The kidney and erythropoiesis. Semin Hematol 4: 337–358

    PubMed  CAS  Google Scholar 

  18. Jacobs K, Shoemaker C, Rudersdorf R, Neill SD, Kaufman RJ, Mufson A, Seehra J, Jones SS, Hewick R, Fritsch EF, Kawakita M, Shimizu T, Miyake T (1985) Isolation and characterization of genomic and cDNA clones of human erythropoietin. Nature 313: 806–810

    Article  PubMed  CAS  Google Scholar 

  19. Jacobson LO, Goldwasser E, Fried W, Plzak L (1957) Role of the kidney in erythropoiesis. Nature 179: 633–634

    Article  PubMed  CAS  Google Scholar 

  20. Jelkmann W (1986) Erythropoietin research, 80 years after the initial studies by Carnot and Deflandre. Respir Physiol 63: 257–266

    Article  PubMed  CAS  Google Scholar 

  21. Jelkmann W, Bauer C (1981) Demonstration of high levels of erythropoietin in rat kidneys following hypoxic hypoxia. Pflügers Arch 392: 34–39

    Article  PubMed  CAS  Google Scholar 

  22. Koury ST, Bondurant MC, Koury MJ (1988) Localization of erythropoietin synthesizing cells in murine kidneys by in situ hybridization. Blood 71: 524–527

    PubMed  CAS  Google Scholar 

  23. Kuratowska Z, Lewartowski B, Michalak E (1961) Studies on the production of erythropoietin by isolated perfused organs. Blood 18: 527–534

    Google Scholar 

  24. Lacombe C, DaSilva JL, Bruneval P, Fournier JG, Wendling F, Casadevall N, Camilleri JP, Bariety J, Varet B, Tambourin P (1988) Peritubular cells are the site of erythropoietin synthesis in the murine hypoxic kidney. J Clin Invest 81: 620–623

    Article  PubMed  CAS  Google Scholar 

  25. Lai PH, Everett R, Wang FF, Arakawa T, Goldwasser E (1986) Structural characterization of human erythropoietin. J Biol Chem 261: 3116–3121

    PubMed  CAS  Google Scholar 

  26. Lin FK, Suggs S, Lin CH, Browne JK, Smalling R, Egrie JC, Chen KK, Fox GM, Martin F, Stabinsky Z, Badrawi SM, Lai PH, Goldwasser E (1985) Cloning and expression of the human erythropoietin gene. Proc Natl Acad Sci USA 82: 7580–7584

    Article  PubMed  CAS  Google Scholar 

  27. Miyake T, Kung CKH, Goldwasser E (1977) Purification of human erythropoietin. J Biol Chem 252: 5558–5564

    PubMed  CAS  Google Scholar 

  28. Papayannopoulou T, Finch CA (1972) On the in vivo action of erythropoietin: a quantitative analysis. J Clin Invest 51: 1179–1185

    Article  PubMed  CAS  Google Scholar 

  29. Recny MA, Scoble HA, Kim Y (1987) Structural characterization of natural human urinary and recombinant DNA-derived erythropoietin. J Biol Chem 262: 17156–17163

    PubMed  CAS  Google Scholar 

  30. Reissmann KR (1950) Studies on the mechanism of erythropoietic stimulation in parabiotic rats during hypoxia. Blood 5: 372–380

    PubMed  CAS  Google Scholar 

  31. Ruhenstroth-Bauer G (1950) Versuche zum Nachweis eines spezifischen erythropoetischen Hormons. Arch Exp Pathol Pharmakol 211: 32–56

    CAS  Google Scholar 

  32. Sasaki H, Bothner B, Dell A, Fukuda M (1987) Carbohydrate structure of erythropoietin expressed in Chinese hamster ovary cells by a human erythropoietin cDNA. J Biol Chem 262: 12059–12076

    PubMed  CAS  Google Scholar 

  33. Schuster SJ, Wilson JH, Erslev AJ, Caro J (1987) Physiologic regulation and tissue localization of renal erythropoietin messenger RNA. Blood 70: 316–318

    PubMed  CAS  Google Scholar 

  34. Viault F (1980) Sur l’augmentation considérable du nombre des globules rouges dans le sang chez les habitants des hauts plateaux de l’Amérique du Sud. CR Acad Sci Paris 111: 917–918

    Google Scholar 

  35. Winearls CG, Oliver DO, Pippard MJ, Reid C, Downing MR, Cotes PM (1986) Effect of human erythropoietin derived from recombinant DNA on the anaemia of patients maintained by chronic haemodialysis. Lancet ii: 1175–1178

    Article  Google Scholar 

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Authors
  1. W. Jelkmann
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  2. A. J. Gross
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Editors and Affiliations

  1. Physiologisches Institut, Medizinische Universität zu Lübeck, Ratzeburger Allee 160, 2400, Lübeck 1, Federal Republic of Germany

    Wolfgang Jelkmann  & Andreas J. Gross  & 

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© 1989 Springer-Verlag Berlin Heidelberg

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Jelkmann, W., Gross, A.J. (1989). Introduction: Advances in Erythropoietin Research. In: Jelkmann, W., Gross, A.J. (eds) Erythropoietin. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-83745-6_1

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  • DOI: https://doi.org/10.1007/978-3-642-83745-6_1

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-83747-0

  • Online ISBN: 978-3-642-83745-6

  • eBook Packages: Springer Book Archive

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