Skip to main content

Role of Neutrophils in Critically Ill Patients: Myeloperoxidase, a Specific Marker of Their Activation

  • Conference paper
Book cover Update 1989

Part of the book series: Update in Intensive Care and Emergency Medicine ((UICM,volume 8))

Abstract

In recent years, the role of neutrophils has been increasingly implicated in tissue injury. Upon activation by different stimuli, neutrophils can release a variety of potentially damaging substances. Lung injury leading to the adult respiratory distress syndrome (ARDS) is thought to be largely associated with neutrophils activation.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Hammerschmidt DE, Weaver LJ, Hudson LD, Craddock PR, Jacob HS (1980) Association of complement activation and elevated plasma C5a with adult respiratory distress syndrome. Lancet 1:947–949

    Article  PubMed  CAS  Google Scholar 

  2. Duchateau J, Hass M, Schreyen H, et al (1984) Complement activation in patients at risk of developing the adult respiratory distress syndrome. Am Rev Respir Dis 130:1058–1064

    PubMed  CAS  Google Scholar 

  3. Hosca SE, Brown E, Hammer G, Frank M (1980) Role of complement activation in a model of adult respiratory distress syndrome. J Clin Invest 66:375–382

    Article  Google Scholar 

  4. Fowler AA, Hyers TM, Fisher BJ, Bechard DE, Centor RM, Webster RO (1987) The adult respiratory distress syndrome. Cell populations and soluble mediators in the air spaces of patients at high risk. Am Rev Respir Dis 136:1225–1231

    Article  PubMed  CAS  Google Scholar 

  5. Jaffe EA (1988) Endothelial cells. In: Gallin JI, Goldstein IM, Snyderman R (eds) Inflammation: Basic principles and clinical correlates. Raven Press, New York, pp 559–576

    Google Scholar 

  6. Worthen GS, Tonnesen MG, Lien DC, Hensen PM (1988) Interaction of leukocytes with the pulmonary endothelium. In: Ryan US (ed) Pulmonary endothelium in health and disease. New York Basel, pp 123–160

    Google Scholar 

  7. Klebanoff SJ (1988) Phagocytic cells: products of oxygen metabolism. In: Gallin JI, Goldsteim IM, Snyderman R (eds) Inflammation: Basic principles and clinical correlates. Raven Press, New York, pp 391–444

    Google Scholar 

  8. Babior BM, Kipnes RS, Curnutte JT (1973) Biological defence mechanisms. Productions by leukocytes of superoxide, a potential bactericidal agent. J Clin Invest 52:741–744

    Article  PubMed  CAS  Google Scholar 

  9. Boes M, Deby C, Pincemail J, Goutier R (1987) Erythrocytes ghosts alteration induced by superoxide anion through a non radical mechanism. Arch Int Physiol Biochem 95: S7–S8

    Google Scholar 

  10. Deby C, Deby-Dupont G, Hans P, Pincemail J, Neuray J, Goutier R (1983) Complementary procedures for pro- and anti-lipoperoxidant activity measurements. Experientia 39:1113–1115

    Article  CAS  Google Scholar 

  11. Corey EJ, Mehrot MM, Khan AU (1987) Water induced dismutation of superoxide anion generates singlet molecular oxygen. Biochim Biophys Res Comm 145(2): 842–846

    Article  CAS  Google Scholar 

  12. Elsbach P, Weiss J (1988) Phagocytic cells: oxygen-independent antimicrobial systems. In: Gallin JI, Goldstein IM, Snyderman R (eds) Inflammation: Basic principles and clinical correlates. Raven Press, New York, pp 445–470

    Google Scholar 

  13. Klebanoff SJ (1968) Myeloperoxidase-halide-hydrogen peroxide antimicrobial system. J Bacteriol 95:2131–2138

    PubMed  CAS  Google Scholar 

  14. Zgliczynski JM, Stelmaszynska T, Domanski J, Ostrowski W (1971) Chloramines as intermediates of oxidation reaction of amino acids by myeloperoxidase. Biochim Biophys Acta 235:419–424

    PubMed  CAS  Google Scholar 

  15. Agner K (1972) Biological effects of hypochlorous acid formed by “MPO”-peroxidation in the presence of chloride anion. In: Akeson SA, Ehrenberg A (eds) Structure and function of oxidation-reduction enzymes, vol 18. Pergamon Press, New York, pp 329–335

    Google Scholar 

  16. Thomas EL, Jefferson MM, Grisham MB (1983) Myeloperoxidase-dependent effect of amines on functions of isolated neutrophils. J Clin Invest 72:441–454

    Article  PubMed  CAS  Google Scholar 

  17. Khan AU (1984) Myeloperoxidase singlet molecular oxygen generation detected by direct infrared electronic emission. Bioch Biphys Res Comm 122:668–675

    Article  CAS  Google Scholar 

  18. Aruoma OI, Halliwell B (1987) Action of hypochlorous acid on the antioxidant protective enzymes superoxide dismutase, catalase and glutathion peroxidase. Biochem J 248:973–976

    PubMed  CAS  Google Scholar 

  19. Matheson NR, Wong PS, Travis J (1979) Enzymatic inactivation of human alpha-1-proteinase inhibitor with neutrophil myeloperoxidase. Biochem Biophys Res Comm 88:402–409

    Article  PubMed  CAS  Google Scholar 

  20. Johnson KJ, Fantone JC III, Kaplan J, Ward PA (1981) In vivo damage of rat lung by oxygen metabolites. J Clin Invest 67:983–993

    Article  PubMed  CAS  Google Scholar 

  21. Johnson RJ, Couser WG, Chi EY, Adler S, Klebanoff SJ (1987) A new mechanism for glomerular injury: The peroxidase-hydrogen peroxide-halide system. J Clin Invest 79:1379–1387

    Article  PubMed  CAS  Google Scholar 

  22. Schultz J, Baker A, Tucker B (1976) Myeloperoxidase-enzyme therapy on rat mammary tumors. In: Schultz J, Ahmad F (eds) Cancer enzymology. Academic Press, New York, pp 319–333

    Google Scholar 

  23. Hechtman HB, Valeri R, Shepro D (1984) Role of humoral mediators in adult respiratory distress syndrome. Chest 86(4): 623–627

    Article  PubMed  CAS  Google Scholar 

  24. Zheutlin LM, Thonar EJ, Jacob ER, Hamley ME, Balk RA, Bone RC (1986) Plasma elas-tase levels in the adult respiratory distress syndrome. J Crit Care 1:39–44

    Article  Google Scholar 

  25. Duswald KH, Jochum M, Schramm W, Fritz H (1985) Released granulocytic elastase: An indication of pathobiochemical alterations in septicemia after abdominal surgery. Surgery 98:892–899

    PubMed  CAS  Google Scholar 

  26. Locksley RM, Nelson CS, Frankhauser JE, Klebanoff IJ (1987) Loss of granule myeloperoxidase during in vitro culture of monocytes correlates which decay in antiprotozoa activity. Am J Trop Med Hyg 36:541–548

    PubMed  CAS  Google Scholar 

  27. Deby-Dupont G, Pincemail J, Thirion A, Deby C (1987) A radioimmunoassay for polymorphonuclear leucocytes myeloperoxidase. Arch Int Physiol Biochem 95:S9-S11

    Google Scholar 

  28. McCay PB, King MM (1980) Vitamin E: its role as a biological free radical scavenger and its relationship to the mixed-function oxidase system. In: Machlin LJ (ed) Vitamin E: a comprehensive treatise. Marcel Dekker, New York, pp 289–318

    Google Scholar 

  29. Chenoweth DE, Cooper SW, Hughi TE, Stewart RW, Blackstone EH, Kirklin JW (1981) Complement activation during cardiopulmonary bypass. Evidence for generation of C3a and C5a anaphylatoxins. N Engl J Med 304:479–503

    Article  Google Scholar 

  30. Lee CT, Fein AM, Lippmann M, Holtzman H, Kimbel P, Weinbaum G (1981) Elastolytic activity in pulmonary lavage fluid from patients with adult respiratory distress syndrome. N Engl J Med 304(4): 192–196

    Article  PubMed  CAS  Google Scholar 

  31. Bertrand Y, Pincemail J, Hanique G, et al (1988) Difference in tocopherol-lipid ratio in ARDS and no ARDS patients. Intensive Care Med (in press)

    Google Scholar 

Download references

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1989 Springer-Verlag Berlin Heidelberg

About this paper

Cite this paper

Pincemail, J., Faymonville, M.E., Lamy, M. (1989). Role of Neutrophils in Critically Ill Patients: Myeloperoxidase, a Specific Marker of Their Activation. In: Vincent, J.L. (eds) Update 1989. Update in Intensive Care and Emergency Medicine, vol 8. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-83737-1_4

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-83737-1_4

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-50879-3

  • Online ISBN: 978-3-642-83737-1

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics