Abstract
In recent years, the role of neutrophils has been increasingly implicated in tissue injury. Upon activation by different stimuli, neutrophils can release a variety of potentially damaging substances. Lung injury leading to the adult respiratory distress syndrome (ARDS) is thought to be largely associated with neutrophils activation.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Hammerschmidt DE, Weaver LJ, Hudson LD, Craddock PR, Jacob HS (1980) Association of complement activation and elevated plasma C5a with adult respiratory distress syndrome. Lancet 1:947–949
Duchateau J, Hass M, Schreyen H, et al (1984) Complement activation in patients at risk of developing the adult respiratory distress syndrome. Am Rev Respir Dis 130:1058–1064
Hosca SE, Brown E, Hammer G, Frank M (1980) Role of complement activation in a model of adult respiratory distress syndrome. J Clin Invest 66:375–382
Fowler AA, Hyers TM, Fisher BJ, Bechard DE, Centor RM, Webster RO (1987) The adult respiratory distress syndrome. Cell populations and soluble mediators in the air spaces of patients at high risk. Am Rev Respir Dis 136:1225–1231
Jaffe EA (1988) Endothelial cells. In: Gallin JI, Goldstein IM, Snyderman R (eds) Inflammation: Basic principles and clinical correlates. Raven Press, New York, pp 559–576
Worthen GS, Tonnesen MG, Lien DC, Hensen PM (1988) Interaction of leukocytes with the pulmonary endothelium. In: Ryan US (ed) Pulmonary endothelium in health and disease. New York Basel, pp 123–160
Klebanoff SJ (1988) Phagocytic cells: products of oxygen metabolism. In: Gallin JI, Goldsteim IM, Snyderman R (eds) Inflammation: Basic principles and clinical correlates. Raven Press, New York, pp 391–444
Babior BM, Kipnes RS, Curnutte JT (1973) Biological defence mechanisms. Productions by leukocytes of superoxide, a potential bactericidal agent. J Clin Invest 52:741–744
Boes M, Deby C, Pincemail J, Goutier R (1987) Erythrocytes ghosts alteration induced by superoxide anion through a non radical mechanism. Arch Int Physiol Biochem 95: S7–S8
Deby C, Deby-Dupont G, Hans P, Pincemail J, Neuray J, Goutier R (1983) Complementary procedures for pro- and anti-lipoperoxidant activity measurements. Experientia 39:1113–1115
Corey EJ, Mehrot MM, Khan AU (1987) Water induced dismutation of superoxide anion generates singlet molecular oxygen. Biochim Biophys Res Comm 145(2): 842–846
Elsbach P, Weiss J (1988) Phagocytic cells: oxygen-independent antimicrobial systems. In: Gallin JI, Goldstein IM, Snyderman R (eds) Inflammation: Basic principles and clinical correlates. Raven Press, New York, pp 445–470
Klebanoff SJ (1968) Myeloperoxidase-halide-hydrogen peroxide antimicrobial system. J Bacteriol 95:2131–2138
Zgliczynski JM, Stelmaszynska T, Domanski J, Ostrowski W (1971) Chloramines as intermediates of oxidation reaction of amino acids by myeloperoxidase. Biochim Biophys Acta 235:419–424
Agner K (1972) Biological effects of hypochlorous acid formed by “MPO”-peroxidation in the presence of chloride anion. In: Akeson SA, Ehrenberg A (eds) Structure and function of oxidation-reduction enzymes, vol 18. Pergamon Press, New York, pp 329–335
Thomas EL, Jefferson MM, Grisham MB (1983) Myeloperoxidase-dependent effect of amines on functions of isolated neutrophils. J Clin Invest 72:441–454
Khan AU (1984) Myeloperoxidase singlet molecular oxygen generation detected by direct infrared electronic emission. Bioch Biphys Res Comm 122:668–675
Aruoma OI, Halliwell B (1987) Action of hypochlorous acid on the antioxidant protective enzymes superoxide dismutase, catalase and glutathion peroxidase. Biochem J 248:973–976
Matheson NR, Wong PS, Travis J (1979) Enzymatic inactivation of human alpha-1-proteinase inhibitor with neutrophil myeloperoxidase. Biochem Biophys Res Comm 88:402–409
Johnson KJ, Fantone JC III, Kaplan J, Ward PA (1981) In vivo damage of rat lung by oxygen metabolites. J Clin Invest 67:983–993
Johnson RJ, Couser WG, Chi EY, Adler S, Klebanoff SJ (1987) A new mechanism for glomerular injury: The peroxidase-hydrogen peroxide-halide system. J Clin Invest 79:1379–1387
Schultz J, Baker A, Tucker B (1976) Myeloperoxidase-enzyme therapy on rat mammary tumors. In: Schultz J, Ahmad F (eds) Cancer enzymology. Academic Press, New York, pp 319–333
Hechtman HB, Valeri R, Shepro D (1984) Role of humoral mediators in adult respiratory distress syndrome. Chest 86(4): 623–627
Zheutlin LM, Thonar EJ, Jacob ER, Hamley ME, Balk RA, Bone RC (1986) Plasma elas-tase levels in the adult respiratory distress syndrome. J Crit Care 1:39–44
Duswald KH, Jochum M, Schramm W, Fritz H (1985) Released granulocytic elastase: An indication of pathobiochemical alterations in septicemia after abdominal surgery. Surgery 98:892–899
Locksley RM, Nelson CS, Frankhauser JE, Klebanoff IJ (1987) Loss of granule myeloperoxidase during in vitro culture of monocytes correlates which decay in antiprotozoa activity. Am J Trop Med Hyg 36:541–548
Deby-Dupont G, Pincemail J, Thirion A, Deby C (1987) A radioimmunoassay for polymorphonuclear leucocytes myeloperoxidase. Arch Int Physiol Biochem 95:S9-S11
McCay PB, King MM (1980) Vitamin E: its role as a biological free radical scavenger and its relationship to the mixed-function oxidase system. In: Machlin LJ (ed) Vitamin E: a comprehensive treatise. Marcel Dekker, New York, pp 289–318
Chenoweth DE, Cooper SW, Hughi TE, Stewart RW, Blackstone EH, Kirklin JW (1981) Complement activation during cardiopulmonary bypass. Evidence for generation of C3a and C5a anaphylatoxins. N Engl J Med 304:479–503
Lee CT, Fein AM, Lippmann M, Holtzman H, Kimbel P, Weinbaum G (1981) Elastolytic activity in pulmonary lavage fluid from patients with adult respiratory distress syndrome. N Engl J Med 304(4): 192–196
Bertrand Y, Pincemail J, Hanique G, et al (1988) Difference in tocopherol-lipid ratio in ARDS and no ARDS patients. Intensive Care Med (in press)
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1989 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Pincemail, J., Faymonville, M.E., Lamy, M. (1989). Role of Neutrophils in Critically Ill Patients: Myeloperoxidase, a Specific Marker of Their Activation. In: Vincent, J.L. (eds) Update 1989. Update in Intensive Care and Emergency Medicine, vol 8. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-83737-1_4
Download citation
DOI: https://doi.org/10.1007/978-3-642-83737-1_4
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-50879-3
Online ISBN: 978-3-642-83737-1
eBook Packages: Springer Book Archive