Skip to main content

Objectives for the Treatment of the Microcirculation in Ischemia, Shock, and Reperfusion

  • Conference paper
Update 1989

Part of the book series: Update in Intensive Care and Emergency Medicine ((UICM,volume 8))

Abstract

Ischemia, shock, and reperfusion exhibit microscopic flow conditions that are inadequate to fulfill the nutritive role of the circulation. A common characteristic of these states is the lack of sufficient arterio-venous pressure gradient to propel blood through the capillary network. This insufficiency can occur in the normal microcirculation, but is invariably aggravated in pathophysiological conditions as a consequence of cellular dysfunctions that increase the hydraulic resistance of the smallest blood vessels.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Lindbom L, Arfors K-E (1985) Mechanism and site of control for variation in the number of perfused capillaries in skeletal muscle. Int J Microcirc Clin Exp 4:19–30

    PubMed  CAS  Google Scholar 

  2. Secomb TW, Fleischman GJ, Papenfuss HD, Intaglietta M, Gross JF (1987) Effects of reduced perfusion and hematocrit on flow distribution in capillary networks. Prog Appl Microcirc 12:297–301

    Google Scholar 

  3. Baez S, Lamport H, Baez A (1960) Pressure effects in living microscopic vessels. In: Copley & Stainsky (eds) Flow properties of blood. Pergamon Press London, pp 122–133

    Google Scholar 

  4. Mazzoni MC, Borgstrom P, Arfors K-E, Intaglietta M (1988) In vivo capillary visualization in skeletal muscle during hemorrhagic shock and fluid reinfusion. Fed Proc 46(6):A1872

    Google Scholar 

  5. Mirhashemi S, Arfors K-E, Messmer K, Intaglietta M (1987) Microcirculatory effects of normovolemic hemodilution in skeletal muscle. Internat J Microcirc Clin Exp 6:359–370

    CAS  Google Scholar 

  6. Mirhashemi S, Ertefai S, Messmer K, Intaglietta M (1987) Model analysis of the enhancement of tissue oxygenation by hemodilution due to increased microvascular flow velocity. Microvasc Res 34:290–310

    Article  PubMed  CAS  Google Scholar 

  7. Tsai AG, Intaglietta M (1988) Hemodynamic and metabolic effects on tissue oxygenation by single red blood cells. Fed Proc 36(6):A1881

    Google Scholar 

  8. Fagrell B, Intaglietta M, Ostergren J (1980) Relative hematocrit in human skin capillaries and its relation to capillary flow velocity. Microvasc Res 20:327–335

    Article  PubMed  CAS  Google Scholar 

  9. Rocha e Silva M, Negraes GA, Soares AM, Pontieri V, Loppnov L (1986) Hypertonic resuscitation from severe hemorrhagic shock: patterns of regional circulation. Circ Shock 19:165–175

    PubMed  CAS  Google Scholar 

  10. Kramer GC, Perron PR, Lindsey DC, Ho HS, Gunther RA, Boyle WA, Holcroft JW (1986) Small volume resuscitation with hypertonic dextran solution. Surgery 100:239–246

    PubMed  CAS  Google Scholar 

  11. Mazzoni MC, Borgstrom P, Arfors K-E, Intaglietta M (1988) Dynamic fluid redistribution in hyperosmotic resuscitation of hypovolemic hemorrhage. Am J Physiol 255: H629–H637

    PubMed  CAS  Google Scholar 

Download references

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1989 Springer-Verlag Berlin Heidelberg

About this paper

Cite this paper

Intaglietta, M. (1989). Objectives for the Treatment of the Microcirculation in Ischemia, Shock, and Reperfusion. In: Vincent, J.L. (eds) Update 1989. Update in Intensive Care and Emergency Medicine, vol 8. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-83737-1_35

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-83737-1_35

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-50879-3

  • Online ISBN: 978-3-642-83737-1

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics