Update 1989 pp 243-247 | Cite as

Nutritional-Metabolic Interactions During Total Parenteral Nutrition in Sepsis

  • I. Giovannini
  • C. Chiarla
  • G. Boldrini
Conference paper
Part of the Update in Intensive Care and Emergency Medicine book series (UICM, volume 8)


Nutritional-metabolic interactions in sepsis may include a large series of effects involving all body systems, such as the immune system or the coagulation system. However, there are some aspects of greater and more specific interest represented by the thermogenic response to the infused nutrients (diet-induced thermogenesis), the nutritionally mediated changes in substrate utilization and some related metabolic-ventilatory interactions.


Total Parenteral Nutrition Amino Acid Infusion Ventilatory Drive Thermogenic Response Thermogenic Effect 
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  1. 1.
    Flatt JP (1978) The biochemistry of energy expenditure. In: Bray GA (ed) Recent advances in obesity research: II. Newman Publishing, London, pp 221–228Google Scholar
  2. 2.
    Heymsfield SB, Head CA, McManus CB III, Seitz S, Slaton GW, Grossman GD (1984) Respiratory, cardiovascular and metabolic effects of enteral hyperalimentation: influence of formula dose and composition. Am J Clin Nutr 40:116–130PubMedGoogle Scholar
  3. 3.
    Askanazi J, Carpentier YA, Elwyn DH, et al (1979) Influence of total parenteral nutrition on fuel utilization in injury and sepsis. Ann Surg 191:40–46CrossRefGoogle Scholar
  4. 4.
    Giovannini T, Chiarla C, Boldrini C, Castiglionl GC, Castagneto M (1988) Calorimetric response to amino acid infusion in sepsis and critical illness. Crit Care Med 16:667–670PubMedCrossRefGoogle Scholar
  5. 5.
    Giovannini I, Boldrini G, Castagneto M, et al (1983) Respiratory quotient and patterns of substrate utilization in human sepsis and trauma, JPEN 7:226–230CrossRefGoogle Scholar
  6. 6.
    Stoner HB, Little RA, Frayn KN, Elebute AE, Tresadern J, Gross E (1983) The effect of sepsis on the oxidation of carbohydrate and fat. Br J Surg 70:32–35PubMedCrossRefGoogle Scholar
  7. 7.
    O’Donnell TF Jr, Clowes GHA Jr, Blackburn GL, Ryan NT, Benotti PN, Miller JDB (1976) Proteolysis associated with a deficit of peripheral energy fuel substrates in septic man. Surgery 80:192–200Google Scholar
  8. 8.
    Cerra FB, Siegel JH, Coleman B, Border JR, McMenamy RR (1980) Septic autocannibalism. A failure of exogenous nutritional support. Ann Surg 192:570–580PubMedCrossRefGoogle Scholar
  9. 9.
    Nordenström J, Carpentier YA, Askanazi J, et al (1982) Metabolic utilization of intravenous fat emulsion during total parenteral nutrition. Ann Surg 196:221–230PubMedCrossRefGoogle Scholar
  10. 10.
    Frayn KN (1985) Substrate turnover after injury. Br Med Bull 41:232–239PubMedGoogle Scholar
  11. 11.
    Siegel JH, Cerra FB, Coleman B, et al (1979) Physiologic and metabolic correlations in human sepsis. Surgery 86:163–193PubMedGoogle Scholar
  12. 12.
    Chiarla C, Siegel JH, Kidd S, et al (1988) Inhibition of post-traumatic septic proteolysis and ureagenesis and stimulation of hepatic acute-phase protein production by branched-chain amino acid TPN. J Trauma 28:1145–1172PubMedCrossRefGoogle Scholar
  13. 13.
    Chiarla C, Giovannini I, Siegel JH, Boldrini G, Coleman W, Castagneto M (1989) The effect of branched chain amino acids (BC) on plasma cholesterol (CHOL) in sepsis. JPEN 13 (in press)Google Scholar
  14. 14.
    Chiarla C, Giovannini I, Siegel JH, Boldrini G, Coleman W, Castagneto M (1988) Effects of branched chain enriched amino acid solutions in sepsis. Clin Nutr 7(S):66Google Scholar
  15. 15.
    Giovannini I, Chiarla C, Boldrini G, Castagneto M (1989) The impact of fat and glucose administration on metabolic and respiratory interactions in sepsis. JPEN 13 (in press)Google Scholar
  16. 16.
    Takala J, Askanazi J, Weissman C, et al (1988) Changes in respiratory control induced by amino acid infusions. Crit Care Med 16:465–469PubMedCrossRefGoogle Scholar
  17. 17.
    Skeie B, Askanazi J, Rothkopf MM, Rosenbaum SH, Kvetan V, Thomashow B (1988) Intravenous fat emulsions and lung function: a review. Crit Care Med 16:183–194PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1989

Authors and Affiliations

  • I. Giovannini
  • C. Chiarla
  • G. Boldrini

There are no affiliations available

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