Abstract
The transport system for oxygen from the environment to the mitochondria comprises a highly complex sequence of diffusive and convective processes, providing several mechanisms to adapt oxygen delivery to the wide variations of metabolic needs in different tissues. If oxygen demand rises, most readily adjustments in pulmonary gas exchange, cardiac output, hemoglobin oxygen binding, vascular tone, distribution of flow and oxygen extraction increase the availability of oxygen to the cell. Hence, systemic oxygen need depends primarily upon the intrinsic metabolic rate, set by the actual physical activity, body temperature, nutritional and metabolic status, level of catecholamines and stress hormones.
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References
Cain SM (1983) Peripheral oxygen uptake and delivery in health and disease. Clin Chest Med 4:139–148
Cain SM (1977) Oxygen delivery and uptake in dogs during anemic and hypoxic hypoxia. J Appl Physiol 42:228–234
Spriet LL, Gledhill N, Froese AB, Wilkes DL (1986) Effect of graded erythrocythemia on cardiovascular and metabolic responses to exercise. J Appl Physiol 61:1942–1948
Schumacker PT, Guth B, Suggett AJ, Wagner PD, West JB (1985) Effects of transfusion-induced polycythemia on O2 transport during exercise in the dog. J Appl Physiol 58:749–758
Klein HG (1985) Blood transfusion and athletics. Games people play. N Engl J Med 312:854–856
Shibutani K, Komatsu T, Kubal K, Sanchala V, Kumar V, Bizzari DV (1983) Critical level of oxygen delivery in anesthetized man. Crit Care Med 11:640–643
Schwartz S, Frantz RA, Shoemaker WC (1981) Sequential hemodynamic and oxygen transport responses in hypovolemia, anemia, and hypoxia. Am J Physiol 241:H864–H871
Kaufman BS, Rackow EC, Falk JL (1984) The relationship between oxygen delivery and consumption during fluid resuscitation of hypovolemic and septic shock. Chest 85:336–340
Haupt MT, Gilbert EM, Carlson RW (1985) Fluid loading increases oxygen consumption in septic patients with lactic acidosis. Am Rev Respir Dis 131:912–916
Gilbert EM, Haupt MT, Mandanas RY, Huaringa AJ, Carlson RW (1986) The effect of fluid loading, blood transfusion, and catecholamine infusion on oxygen delivery and consumption in patients with sepsis. Am Rev Respir Dis 134:873–878
Astiz ME, Rackow EC, Kaufman B, Falk JL, Weil MH (1988) Relationship of oxygen delivery and mixed venous oxygenation to lactic acidosis in patients with sepsis and acute myocardial infarction. Crit Care Med 16:655–658
Mohsenifar Z, Goldbach P, Tashkin DP, Campisi DJ (1983) Relationship between O2 delivery and O2 consumption in the adult respiratory distress syndrome. Chest 84:267–271
Kariman K, Burns S (1985) Regulation of tissue oxygen extraction is disturbed in adult respiratory distress syndrome. Am Rev Respir Dis 132:109–114
Danek SJ, Lynch JP, Weg JG, Dantzker DR (1980) The dependence of oxygen uptake on oxygen delivery in the adult respiratory distress syndrome. Am Rev Respir Dis 122:387–395
Wolf YG, Cotev S, Perel A, Manny J (1987) Dependence of oxygen consumption on cardiac output in sepsis. Crit Care Med 15:198–203
Rhodes GR, Newell JC, Shah D, et al (1978) Increased oxygen consumption accompanying increased oxygen delivery with hypertonic mannitol in adult respiratory distress syndrome. Surgery 84:490–497
Chapell TR, Rubin LJ, Markham RV, Firth BG (1983) Independence of oxygen consumption and systemic oxygen transport in patients with either stable pulmonary hypertension or refractory left ventricular failure. Am Rev Respir Dis 128:30–33
Abraham E, Shoemaker WC, Cheng PH (1984) Cardiorespiratory responses to fluid administration in peritonitis. Crit Care Med 12:664–668
Bihari D, Smithies M, Gimson A, Tinker J (1987) The effects of vasodilation with prostacyclin on oxygen transport and uptake in critically ill patients. N Engl J Med 317:397–402
Schumacker PT, Cain SM (1987) The concept of critical oxygen delivery. Crit Care Med 13:223–229
Wood LDH, Prewitt RM (1981) Cardiovascular management in hypoxemic respiratory failure. Am J Cardiol 47:963–972
Royall J, Levin DL (1988) Adult respiratory distress syndrome in pediatric patients. II. Management. J Pediatr 112:335–347
Laver MB, Strauss HW, Pohost GM (1979) Right and left ventricular geometry: adjustments during acute respiratory failure. Crit Care Med 7:509–519
Thijs LG (1988) Transport and consumption of oxygen in septic shock. In: Vincent JL (ed) Update 1988. (Update in intensive care and emergency medicine, vol. 5) Springer, Berlin Heidelberg New York Tokyo, pp 44–50
Iannuzzi M, Petty TL (1986) The diagnosis, pathogenesis, and treatment of adult respiratory distress syndrome. J Thorac Imag 1:1–10
Asmundsson T, Kilburn KH (1969) Survival of acute respiratory failure: a study of 239 episodes. Ann Intern Med 70:471–476
Boucher BA, Foster TS (1984) The adult respiratory distress syndrome. Drug Intell Clin Pharm 18:862–868
Murray JF, Gold P, Johnson BLJr (1963) The circulatory effects of hematocrit variations in normovolemic and hypervolemic dogs. J Clin Invest 42:1150–1159
Messmer K, Sunder-Plassmann L, Klövekorn WP, Holper K (1972) Circulatory significance of hemodilution: rheological changes and limitations. Adv Microcirc 4:1–77
Agarwal JB, Paltoo R, Palmer WH (1970) Relative viscosity of blood at varying hematocrits in pulmonary circulation. J Appl Physiol 29:866–871
Prewitt RM, Ghignone M (1983) Treatment of right ventricular dysfunction in acute respiratory failure. Crit Care Med 11:346–352
Prewitt RM, Raizen M, Ghignone M, Girling L (1984) Effects of increased hematocrit (viscous load) on right ventricular function in canine acute respiratory failure. Am Rev Respir Dis 129:A98 (Abstract)
Kahn RC, Zaroulis C, Goetz W, Howland WS (1986) Hemodynamic oxygen transport and 2,3-diphosphoglycerate changes after transfusion of patients in acute respiratory failure. Intensive Care Med 12:22–25
Smoller BR, Kruskall MS (1986) Phlebotomy for diagnostic laboratory tests in adults. Pattern of use and effect on transfusion requirements. N Engl J Med 314:1233–1235
Optimal hematocrit (Round Table). Moderator: D Bihari, Participants: JF Baron, DR Dantzker, MT Haupt, K Messmer. Eighth International Symposium on Intensive Care and Emergency Medicine. Bruxelles March 22–25, 1988
Czer LSC, Shoemaker WC (1978) Optimal hematocrit value in critically ill postoperative patients. Surg Gynecol Obstet 147:363–368
Montgomery AB, Stager MA, Carrico CJ, Hudson LD (1985) Causes of mortality in patients with adult respiratory distress syndrome. Am Rev Respir Dis 132:485–489
Murray JF, Matthay MA, Luce JM, Flick MR (1988) An expanded definition of the adult respiratory distress syndrome. Am Rev Respir Dis 138:720–723
Astiz ME, Rackow EC, Falk JL, Kaufman BS, Weil MH (1987) Oxygen delivery and consumption in patients with hyperdynamic shock. Crit Care Med 15:26–28
Beutler E, Wood L (1969) In vivo regeneration of red cell 2,3 di-phosphate-glyceric acid (DPG) after transfusion of stored blood. J Lab Clin Med 74:300–304
Brinker JA, Weiss JL, Lappe DL, Rabson JL, Summer WR, Permutt S (1980) Leftward septal displacement during right ventricular loading in man. Circulation 61:626–633
Shoemaker WC, Appel PL (1986) Effects of prostaglandin El in adult respiratory distress syndrome. Surgery 99:275–283
Soulier JP (1984) Diseases transmissable by blood transfusion. Vox Sang 47:1–6
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Forst, H., Haller, M., Adler, M. (1989). Effects of Transfusion on Systemic Oxygen Uptake. In: Vincent, J.L. (eds) Update 1989. Update in Intensive Care and Emergency Medicine, vol 8. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-83737-1_27
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DOI: https://doi.org/10.1007/978-3-642-83737-1_27
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