Murine Hepatitis Induced by Frog Virus 3 (FV3)
In the course of a virus infection of the liver, hepatocellular damage may result either directly from the replication of virus particles in the parenchymal cells, as is the case in mouse hepatitis, (Bang and Warwick, 1959) or indirectly from the effect of immunological factors in response to an antigenic virus-induced transformation of the hepatocyte membrane. The toxic degenerative hepatitis produced by Frog Virus 3 in mice or rats (Kirn, 1971; Kirn et al., 1972) constitutes a new model of hepatocellular injury in which the damage to the parenchymal cells is secondary to sinusoidal cell necrosis produced by FV 3 particles or FV 3 proteins.
KeywordsToxicity Hepatitis Interferon Leucin Indomethacin
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