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Murine Hepatitis Induced by Frog Virus 3 (FV3)

  • A. Kirn
  • J. L. Gendrault
  • A. M. Steffan
  • J. P. Gut
  • A. Bingen

Abstract

In the course of a virus infection of the liver, hepatocellular damage may result either directly from the replication of virus particles in the parenchymal cells, as is the case in mouse hepatitis, (Bang and Warwick, 1959) or indirectly from the effect of immunological factors in response to an antigenic virus-induced transformation of the hepatocyte membrane. The toxic degenerative hepatitis produced by Frog Virus 3 in mice or rats (Kirn, 1971; Kirn et al., 1972) constitutes a new model of hepatocellular injury in which the damage to the parenchymal cells is secondary to sinusoidal cell necrosis produced by FV 3 particles or FV 3 proteins.

Keywords

Parenchymal Cell Orotic Acid Hepatocellular Injury Sinusoidal Cell Frog Virus 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1989

Authors and Affiliations

  • A. Kirn
    • 1
  • J. L. Gendrault
    • 1
  • A. M. Steffan
    • 1
  • J. P. Gut
    • 1
  • A. Bingen
    • 1
  1. 1.Laboratoire de VirologieUnité INSERM U 74StrasbourgFrance

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