Abstract
Although the overall architecture of DNA has been clear since the work of Watson and Crick, the-detailed structure of DNA (and its dependence on sequence) is still an area of active research. The chief experimental difficulty is that DNA as it exists in biological systems is a very large molecule. The traditional methods for chemical structure determination (for example, X-ray crystallography and NMR), while able to provide important insights into the structures of small DNA oligonucleotides, are at a loss when structural information is needed on much larger natural DNA molecules.
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© 1989 Springer-Verlag Berlin Heidelberg
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Tullius, T.D. (1989). Structural Studies of DNA Through Cleavage by the Hydroxyl Radical. In: Eckstein, F., Lilley, D.M.J. (eds) Nucleic Acids and Molecular Biology. Nucleic Acids and Molecular Biology, vol 3. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-83709-8_1
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DOI: https://doi.org/10.1007/978-3-642-83709-8_1
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