The Contribution of Clinical Trials to the Study of Breast Cancer
The purpose of oncological clinical research is to improve the care of patients with cancer. This improvement can be manifested in a variety of efficacy parameters which have become the evaluation focus of the clinical trials which comprise the bulk of clinical research. The benefit to patients from having their malignant tumors treated can be easily separated into two broad concepts. The first concept is cure and the second concept is palliation. A major problem in clinical research evaluation involves the determination of how the benefits of a given investigative regimen, or therapeutic approach, actually translate into a population-based patient care therapeutic index. It is the purpose of this paper to discuss some of the issues involved in this determination.
KeywordsBreast Cancer Overall Survival Adjuvant Chemotherapy Historical Control Therapeutic Index
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