Regulation of Macrophage Cholesterol Homeostasis
Lipoprotein receptors play a major role in the homeostasis of plasma lipoproteins. They are integrated constituents of cell membranes and bind certain lipoproteins which are then internalized by the cells. Insofar as lipoprotein receptors affect the concentration of lipoproteins in the plasma and may play a role in lipoprotein accumulation in arterial cells, they have both a direct and an indirect influence on the progression of atherosclerosis. The occurence of receptor defects  or structural defects of apolipoproteins  prevent a normal lipoprotein-receptor interaction. The abnormal lipoprotein particles thus formed are enriched with cholesteryl esters and are catabolized via a separate, so-called scavenger pathway in the macrophage system.
KeywordsCholesteryl Ester Cholesterol Efflux Lamellar Body Unesterified Cholesterol Cytoplasmic Lipid Droplet
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