Tumorigenesis and Tumor Markers

  • Frank B. Gelder
  • Valerian B. Pinto
Part of the Medical Radiology book series (MEDRAD)


Until recently, the bulk of basic information about cancer came from studies which defined phenotypic differences between malignant and normal cells and tissues. The information gained from these studies indicates that cancer cells share certain characteristics. However, these comparative studies failed to define clear-out cancer cell specific alterations or explain the mechanisms responsible for both the induction and the aberrant behavior of tumor cells. Recent technological advances, especiallyat the molecular and gcnctic level, promise to com-plement substantially and extend these earlier com-parative studies. Although several areas of investi-gation have contributed to the rapidly expandingknowledge defining canccr biology, two avenueswere of central importance: (a) the biological andbiochemical characterization of DNA and RNA tu-mor viruses leading to techniques in somatic cellhybridization, chromosomal transfer, and l)NAtransfection, and (b) the identification and utiliza-tion of bacterial restriction endonuclease enzymes,leading to the molecular cloning and detailed anal-yses of discrete DNA segments.


Epidermal Growth Factor Receptor Carcinoembryonic Antigen Small Cell Carcinoma Bovine Leukemia Virus Prostatic Acid Phosphatase 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Berlin Heidelberg 1990

Authors and Affiliations

  • Frank B. Gelder
    • 1
  • Valerian B. Pinto
    • 2
  1. 1.Louisiana State University Medical CenterShreveportUSA
  2. 2.Department of Microbiology/ImmunologyLouisiana State University Medical CenterShreveportUSA

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