GAP-JUNCTION: Braille of the Cell

  • Jon J. Kabara
Conference paper
Part of the NATO ASI Series book series (volume 42)


Considerable attention has been focused in the effects of dietary parameters on carcinogenesis (Carroll & Khor, 1975). While total fat intake has been implicated in some types of cancer (i.g. breast, colon), not all studies support a positive association. Some epidemlologic studies in Western populations (Stemmerman et al, 1984; Willett et al, 1987) or even animal studies, have failed to show such correlations. It is clear however in animal experiments (Roebuck et al, 1981; Naus et al, 1983) that high fat intake was shown to increase carcinogenesis response. Kritchevsky et al, 1984 maintains that it is the total caloric intake which is important in the promotion of tumors rather than dietary fat per se. The issue while not resolved will be less confusing if the diet is described in terms of specific fats, rather than simply dietary fat.


Acid Sorbic Total Caloric Intake Metabolic Cooperation Length Fatty Acid Longe Chain Unsaturated Fatty Acid 
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  1. Aylsworth CF, Welsch CW, Kabara JJ and Trosko JE (1989) Effects of fatty acids on gap junction communication: possible role in tumor promotion by dietary fat, Lipids 22: 445–454.CrossRefGoogle Scholar
  2. Carroll KK & Khor HT (1975) Dietary fat in relation to tumorigenesis, Prog Biochem Pharmacol 10: 308–353.PubMedGoogle Scholar
  3. Galli C, Mosconi C, Col1i S, Stragliotto E, Medini L and Tremoli E (1987) Dietary EPA alone or with Vitamin E supplementation: Differential effects on platelet and leukocyte fatty acids, elcosanolds production and functional parameters. In Lands WEM (ed) Polyunsaturated Fatty Acids and Eicosanoids Am Oil Chem Soc, Champaign, p399–403.Google Scholar
  4. Kabara, JJ (1979) Fatty acids and derivatives as anitmicrobial agents — A review. In: Kabara JJ (ed) The Pharmacological Effects of Lipids, Am Oil Chem Soc, Champaign, p1–14.Google Scholar
  5. Kritchevsky D, Weber MM, Klurfeld DM (1984) Dietary fat versus caloric content in initiation and promotion of 7,12-dimethy1 benz(a)-anthracente-induced mamary tumorigenesis In rats. Cancer Res. 44: 3174–3177PubMedGoogle Scholar
  6. Naus KM, Locniskar M, Newberne PM (1983) Effect of Alterations in the quality and quantity of dietary fat m 1, 2-dimethylhydrazine-induced colon tumorigenesis In rats. Cancer Res 43: 4083–4090.Google Scholar
  7. Roebuck BD, Yager JD Jr, Longnecker DS et al (1981) Promotion by unsaturated fat of azaserine-induced pancreatic carcinogenesis in the rat. Cancer Res 41: 3961–3966.PubMedGoogle Scholar
  8. Stemmermann GN, Nomura AMY, Heilbrun LK (1984) Dietary fat and the risk of colorectal cancer. Cancer Res 44: 4633–4637.PubMedGoogle Scholar
  9. Trosko JE, Jone C, Aylsworth CF and Chang CC (1985) la Vitro assay to detect inhibitors of intercellular communication. In: Mllman HA and Welsburger EK (ed) Handbook of Carcinogen Testing, Noyes Publication. Park Ridge, NJ P422–437.Google Scholar
  10. Willett WC, Stampfer MJ, Colditz GA et al (1987) Dietary fat and risk of breast cancer. N Engle J Med 316: 22–28.CrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1990

Authors and Affiliations

  • Jon J. Kabara
    • 1
  1. 1.Lauricidin Inc.GalenaUSA

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