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Heterogeneity Amongst Myo-Inositol Derivatives: Metabolism of Second Messengers and Synthesis of Co-Signals

  • C. R. Downes
  • L. R. Stephens
  • P. T. Hawkins
Conference paper
Part of the NATO ASI Series book series (volume 44)

Abstract

Myo-inositol is one of nine possible isomers of hexahydroxy cyclohexane in which the 2-hydroxyl is axial to the plane of the 6 membered ring with the remaining hydroxyl groups all being equatorial (Cosgrove, 1980). This configuration ensures that simple derivatives of myo-inositol, such as inositol phosphates, can occur in a variety of isomeric forms e.g. there are 20 possible inositol trisphosphate isomers. Recent studies have uncovered a bewildering complexity of cellular inositol metabolism, much of which is concerned with metabolism of the Ca2+-mobilising second messenger, inositol 1,4,5-trisphosphate (Ins1,4,5P3 3). On the other hand, certain inositol phosphates isomers appear to be involved with the synthesis of inositol polyphosphates such as inositol pentakis- and hexakisphosphate (InsP5 and InsP6) whose function and metabolic relationships to the fast signalling events triggered by receptor stimulated cleavage of phosphatidylinositol 4,5-bisphosphate (PtdIns4,5P2) are not yet understood (see Downes, 1988 and references therein). In addition a novel inositol phospholipid (phosphatidylinositol 3-phosphate, PtdIns3P) has recently been described (Whitman et al, 1988; Stephens et al 1989b) whose synthesis may be regulated by the association of a Ptdlns 3-kinase with activated tyrosine kinases such as the receptor for platelet derived growth factor (PDGF; Whitman et al, 1987).

Keywords

Inositol Phosphate Inositol Trisphosphate Inositol Phospholipid Inositol Polyphosphates Avian Erythrocyte 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1990

Authors and Affiliations

  • C. R. Downes
    • 1
  • L. R. Stephens
    • 1
  • P. T. Hawkins
    • 1
  1. 1.Smith Kline and French Research Limited The Frythe WELWYNHertsEngland

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