Heterogeneity Amongst Myo-Inositol Derivatives: Metabolism of Second Messengers and Synthesis of Co-Signals

  • C. R. Downes
  • L. R. Stephens
  • P. T. Hawkins
Conference paper
Part of the NATO ASI Series book series (volume 44)

Abstract

Myo-inositol is one of nine possible isomers of hexahydroxy cyclohexane in which the 2-hydroxyl is axial to the plane of the 6 membered ring with the remaining hydroxyl groups all being equatorial (Cosgrove, 1980). This configuration ensures that simple derivatives of myo-inositol, such as inositol phosphates, can occur in a variety of isomeric forms e.g. there are 20 possible inositol trisphosphate isomers. Recent studies have uncovered a bewildering complexity of cellular inositol metabolism, much of which is concerned with metabolism of the Ca2+-mobilising second messenger, inositol 1,4,5-trisphosphate (Ins1,4,5P3 3). On the other hand, certain inositol phosphates isomers appear to be involved with the synthesis of inositol polyphosphates such as inositol pentakis- and hexakisphosphate (InsP5 and InsP6) whose function and metabolic relationships to the fast signalling events triggered by receptor stimulated cleavage of phosphatidylinositol 4,5-bisphosphate (PtdIns4,5P2) are not yet understood (see Downes, 1988 and references therein). In addition a novel inositol phospholipid (phosphatidylinositol 3-phosphate, PtdIns3P) has recently been described (Whitman et al, 1988; Stephens et al 1989b) whose synthesis may be regulated by the association of a Ptdlns 3-kinase with activated tyrosine kinases such as the receptor for platelet derived growth factor (PDGF; Whitman et al, 1987).

Keywords

Lithium Adenosine Sarcoma Astrocytoma Inositol 

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Copyright information

© Springer-Verlag Berlin Heidelberg 1990

Authors and Affiliations

  • C. R. Downes
    • 1
  • L. R. Stephens
    • 1
  • P. T. Hawkins
    • 1
  1. 1.Smith Kline and French Research Limited The Frythe WELWYNHertsEngland

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