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Agonist and Guanine Nucleotide Regulation of P2Y Purinergic Receptor-Linked Phospholipase C

  • Conference paper
Activation and Desensitization of Transducing Pathways

Part of the book series: NATO ASI Series ((ASIH,volume 44))

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Abstract

Extracellular adenine nucleotides interact with cell surface receptors to produce a myriad of physiological effects in the central nervous system and peripheral tissues (Burnstock, 1978; Gordon, 1986; Burnstock and Kennedy, 1986; Fleetwood and Gordon, 1987). Burnstock proposed in 1978 that these responses are mediated by two major receptor types: those physiologically activated by adenosine, called P1-purinergic receptors, and exhibiting a potency order of adenosine > AMP > ATP, and those activated by ATP or ADP, called P2-purinergic receptors, and exhibiting the potency order of ATP > ADP > AMP > adenosine. Subsequent studies proved that at least two subtypes of P1-purinergic receptors exist (A1- and A2- purinergic receptors) (Van Calker et al., 1979; Stiles, 1986; Williams, 1987). Subclassification of P2-purinergic receptors proved more difficult, since in contrast to the receptors for adenosine, no good antagonists of P2-purinergic receptors are available, and cell surface hydrolases readily metabolize ATP and ADP to adenosine, which can then produce physiological effects through P1-purinergic receptors. However, the development of relatively non-hydrolyzable analogs of ATP helped resolve this issue, and the observation of differential effects of a large number of ATP and ADP analogs led Burnstock and Kennedy to propose in 1985 that subypes of P2-purinergic receptors exist. P2X-purinergic receptors exhibit the potency order of Ap(CH2)pp > App(CH2)p > ADP > 2-methylthio ATP (2MeSATP) and P2Y-purinergic receptors exhibit the potency order of 2MeSATP > ATP > Ap(CH2)pp = App(CH2)p.

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Authors and Affiliations

  1. Department of Pharmacology, University of North Carolina School of Medicine, Chapel Hill, North Carolina, 27599, USA

    J. L. Boyer, M. W. Martin, C. L. Cooper, G. L. Waldo, A. J. Morris, H. A. Brown, R. A. Jeffs, J. R. Hepler, C. P. Downes & T. K. Harden

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  1. J. L. Boyer
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  2. M. W. Martin
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  3. C. L. Cooper
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  4. G. L. Waldo
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  5. A. J. Morris
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  7. R. A. Jeffs
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  8. J. R. Hepler
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  9. C. P. Downes
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  10. T. K. Harden
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Editor information

Editors and Affiliations

  1. Zoölogisch Laboratorium, Kaiserstraat 63, POB 9516, 2300 RA, Leiden, The Netherlands

    T. M. Konijn

  2. Institute of Biochemistry, The University of Glasgow, G12 8QQ, Glasgow, Scotland

    M. D. Houslay

  3. Biochemisch Laboratorium, Nijenborgh 16, POB, 9747 AG, Groningen, The Netherlands

    P. J. M. Van Haastert

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© 1990 Springer-Verlag Berlin Heidelberg

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Boyer, J.L. et al. (1990). Agonist and Guanine Nucleotide Regulation of P2Y Purinergic Receptor-Linked Phospholipase C. In: Konijn, T.M., Houslay, M.D., Van Haastert, P.J.M. (eds) Activation and Desensitization of Transducing Pathways. NATO ASI Series, vol 44. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-83618-3_11

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  • DOI: https://doi.org/10.1007/978-3-642-83618-3_11

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-83620-6

  • Online ISBN: 978-3-642-83618-3

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