Activation and Densensitization in Bacterial Chemotaxis

  • Melvin I. Simon
Conference paper
Part of the NATO ASI Series book series (volume 44)


Bacterial chemotaxis allows cells to respond to over 35 different There are transmembrane cell surface The bound state of the receptor intracellular protein kinase that can phosphorylate two chemotaxis system components, the CheY and the CheB proteins. When CheY is phosphorylated it modulates bacterial flagellar rotation and thus effects the cells’ movement. When CheB is phosphorylated it increases its ability to modify the cell surface receptor and change its sensitivity. A model for the integration of these steps into a scheme that can explain the dynamic range, rapid response and sensitivity of the bacterial sensory system is described. This represents one example of a much larger group of “two component” sensory systems in bacteria.


Signal transduction Chemotaxis protein kinase transphosphorylation 


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Copyright information

© Springer-Verlag Berlin Heidelberg 1990

Authors and Affiliations

  • Melvin I. Simon
    • 1
  1. 1.Biology Division, 147-75California Institute of TechnologyPasadenaUSA

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