The Eberbach/Wiesloch Study: Influence of Cigarette Smoking on Lipoprotein Profiles
Plasma lipid and lipoprotein profiles, plasma cotinine levels, and smoking habits of a randomly selected sample of middle-aged men and women in two representative towns of the Federal Republic of Germany were investigated. Mean plasma cholesterol and triglyceride levels were significantly higher in smoking men and women. Smoking women had significantly reduced high-density lipoprotein (HDL) cholesterol levels. Smokers of both sexes had 16- to 20-fold higher plasma cotinine levels than non- or ex-smokers. Plasma cotinine levels correlated positively with very-low-density lipoprotein (VLDL) triglycerides, VLDL- cholesterol, intermediate-density lipoprotein (IDL) triglycerides, low-density lipoprotein (LDL) triglycerides, VLDL-apoprotein (Apo) CI, and HDL3-Apo CII in men and women. Positive correlations between plasma cotinine and Apo CII, Apo CIII1, and Apo CIII2 of VLDL were only observed in women. On the other hand, plasma cotinine correlated negatively with HDL2 cholesterol, HDL2 phospholipids, and HDL2 Apo CIII1 in both sexes. Futhermore, in women, plasma cotinine correlated negatively with HDL2 APO AI, HDL2 APO AII, HDL2 Apo CI, HDL2 Apo CII, and HDL2 Apo CIII0.
These results suggest that chronic cigarette smoking has profound effects on plasma lipid and lipoprotein profiles, which become much more evident when plasma cotinine levels are used as a quantitative parameter for cigarette consumption. Plasma cotinine seems a reliable and objective parameter to study the influence of smoking habits. Finally, lipoprotein profiles of men and women are affected differently.
KeywordsCholesterol Obesity Filtration Albumin Urea
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