The Eberbach/Wiesloch Study: Influence of Cigarette Smoking on Lipoprotein Profiles

  • J. Augustin
  • J. Grulich-Henn
  • W. Haberbosch
  • L. Buchholz
  • W. Morgenstern
  • F.-E. Nüssel
  • G. Schettler
Conference paper
Part of the Veröffentlichungen aus der Geomedizinischen Forschungsstelle der Heidelberger Akademie der Wissenschaften book series (HD AKAD, volume 1988 / 1988/4)


Plasma lipid and lipoprotein profiles, plasma cotinine levels, and smoking habits of a randomly selected sample of middle-aged men and women in two representative towns of the Federal Republic of Germany were investigated. Mean plasma cholesterol and triglyceride levels were significantly higher in smoking men and women. Smoking women had significantly reduced high-density lipoprotein (HDL) cholesterol levels. Smokers of both sexes had 16- to 20-fold higher plasma cotinine levels than non- or ex-smokers. Plasma cotinine levels correlated positively with very-low-density lipoprotein (VLDL) triglycerides, VLDL- cholesterol, intermediate-density lipoprotein (IDL) triglycerides, low-density lipoprotein (LDL) triglycerides, VLDL-apoprotein (Apo) CI, and HDL3-Apo CII in men and women. Positive correlations between plasma cotinine and Apo CII, Apo CIII1, and Apo CIII2 of VLDL were only observed in women. On the other hand, plasma cotinine correlated negatively with HDL2 cholesterol, HDL2 phospholipids, and HDL2 Apo CIII1 in both sexes. Futhermore, in women, plasma cotinine correlated negatively with HDL2 APO AI, HDL2 APO AII, HDL2 Apo CI, HDL2 Apo CII, and HDL2 Apo CIII0.

These results suggest that chronic cigarette smoking has profound effects on plasma lipid and lipoprotein profiles, which become much more evident when plasma cotinine levels are used as a quantitative parameter for cigarette consumption. Plasma cotinine seems a reliable and objective parameter to study the influence of smoking habits. Finally, lipoprotein profiles of men and women are affected differently.


Plasma Lipid Lipoprotein Metabolism Lipoprotein Fraction Lipoprotein Profile Smoking Woman 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Augustin J, Beedgen B, Spohr U, Winkel F (1982) The influence of smoking on the plasmalipoproteins. Inn Med 9:104-108Google Scholar
  2. 2.
    Carlson LA, Boettiger LE (1972) Ischaemic heart disease in relation to fasting values of plasma triglyceride and cholesterol. Lancet 1:865-868PubMedCrossRefGoogle Scholar
  3. 3.
    Department of Health and Human Services (1983) The health consequences of smoking: cardiovascular disease. A report of the surgeon general. Rockville, MDGoogle Scholar
  4. 4.
    Doll R, Peto R (1976) Mortality in relation to smoking: 20 years observations on male British doctors. Br Med J 2:1525-1536PubMedCrossRefGoogle Scholar
  5. 5.
    Doyle JT, Dawber TR, Kannel WB, Heslin AS, Kahn HA (1962) Cigarette smoking and coronary heart disease. N Engl J Med 266:796CrossRefGoogle Scholar
  6. 6.
    Doyle JT, Dawber TR, Kannel WB, Kinch SH, Kahn HA (1964) The relationship of cigarette smoking to coronary heart disease. JAMA 190:108Google Scholar
  7. 7.
    Fielding JE (1985) Smoking: Health Effects on Control. N Engl J Med 313:491-498PubMedCrossRefGoogle Scholar
  8. 8.
    Gnasso A, Lehner B, Haberbosch W, Leiss O, von Bergmann L, Augustin J (1986) Effects of Gemofibrozil on lipids, apoproteins, and postheparin lipolytic activities in normolipidemic subjects. Metabolism 35:387-393PubMedCrossRefGoogle Scholar
  9. 9.
    Gofman JW, Lindgren FT, Strisower B, de Lalla O, Glazier F, Tamplin A (1955) Cigarette smoking, serum lipoproteins and coronary heart disease. Geriatrics 10:349PubMedGoogle Scholar
  10. 10.
    Haberbosch W, Poli A, Marx A, Augustin J (1982) Quantification of Apoproteins - Clinical Significance. Inn Med 9:99-103Google Scholar
  11. 11.
    Hengen N, Hengen M (1978) Gas liquid chromatographic determination of nicotine and cotinine in plasma. Clin. Chem. 24:50-55PubMedGoogle Scholar
  12. 12.
    Kershbaum A, Bellet S, Khorsandian R (1965) Elevation of serum cholesterol after administration of nicotine. Am Heart J 69:206-210PubMedCrossRefGoogle Scholar
  13. 13.
    Kershbaum A, Bellet S (1968) Cigarette, cigar and pipe smoking. Geriatrics 23:126PubMedGoogle Scholar
  14. 14.
    Paul O, Lepper MH, Phelan WH, Dupertuis GW, Macmillan A, McKean H, Park H (1963) Coronary heart disease in industrial population: prospective Study. Circulation 28:20- 31PubMedCrossRefGoogle Scholar
  15. 15.
    Pisa Z, Strasser T (1981) Comprehensive cardiovascular control programme in the Community. WHO Europe, Copenhagen. Public Health Eur 5:101-114Google Scholar
  16. 16.
    Schettler G (1978) Die Atiologie der Arteriosklerose. Der Internist 19:611- 620PubMedGoogle Scholar
  17. 17.
    Schettler G, Gotto AM, Middelhoff G, Habenicht AJR, Jurutka KR (eds) Atherosclerosis VI. Springer, Berlin Heidelberg New York, pp 873 - 910 ("Smoking and atherosclerosis")Google Scholar
  18. 18.
    Spain DM, Nathan DJ (1961) Smoking habits and coronary artherosclerotic heart disease. JAMA 177:683 - 688CrossRefGoogle Scholar
  19. 19.
    Wirth A (1982) Beeinflussung koronarer Risikofaktoren durch kőrperliches Training. Inn Med 9:130-133Google Scholar
  20. 20.
    Wynder EL, Hoffmann D, Gori GB (1975) Smoking and health. Proceedings of the 3rd World Conference. Modifying the Risk for the Smoker. DHEW Pub I No (NIH) 76-1221Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1988

Authors and Affiliations

  • J. Augustin
  • J. Grulich-Henn
  • W. Haberbosch
  • L. Buchholz
  • W. Morgenstern
  • F.-E. Nüssel
  • G. Schettler

There are no affiliations available

Personalised recommendations