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Experimental Models for Joint Allografting

  • V. M. Goldberg
Conference paper

Abstract

Advances in the management of musculoskeletal tumors have enabled surgeons to perform limb-sparing procedures. Salvage procedures for periarticular trauma, congenital abnormalities, and degenerative processes also require large osteochondral bone grafts [11, 14, 18–20, 29]. Resurfacing osteochondral surfaces with allografts for degenerative joint disease has also been performed with varying success [11]. As a result, there has been an increased need for osteochondral grafts. Judet in 1908 first reported experimental transplantation of hemijoints and whole joints with a preservation of joint surface geometry, but with gradual cartilage deterioration and bony collapse [15]. Subsequently, many reports have confirmed these results with both autografts and allografts and have identified the major problems leading to failure [14, 18–20, 29]. These include technical difficulties with fixation and joint fit and biological causes such as delayed and incomplete revascularization and inadequate mineralization. When allografts have been used, an immune response directed toward donor antigens may be responsible for graft failure, but no studies to date have correlated the clinical outcome with this event. These problems are still unsolved, and additional experimental studies are necessary to delineate the role of these factors in determining the success or failure of osteoarticular grafts. This chapter reviews some of the experimental models that have been utilized to study hemijoint and whole joint transplantation.

Keywords

Articular Cartilage Subchondral Bone Osteochondral Graft Osteochondral Allograft Freeze Allograft 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag, Berlin Heidelberg 1989

Authors and Affiliations

  • V. M. Goldberg
    • 1
  1. 1.Department of OrthopaedicsCase Western Reserve UniversityClevelandUSA

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