Biology of Cortical Bone Graft Incorporation
Bone transplantation has been a common surgical procedure since the early 1900s when it was used to unite fractures, fuse joints, and repair skeletal defects. The use of autogenous bone grafts for skeletal reconstruction has changed little since that time, and the incidence of success has remained high. To understand the reasons for the success of this surgical procedure, the interacting biomechanisms of bone graft repair need to be reviewed: the correct application of transplantable bone tissues is based on knowing the biological sequences that occur from the time of transplantation to the incorporation and secondary remodeling of the graft. This presentation discusses the biological and physical characteristics of autogenous cortical bone transplantation repair as studied in an experimental model and, secondarily, makes some correlations to autogenous cortical segmental grafts in man [7, 8].
KeywordsFatigue Porosity Osteoporosis Immobilization Hematoxylin
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- 1.Abbott LC, Schottstaedt ER, Saunders JB et al. (1947) The evaluation of cortical and cancellous bone as grafting material: a clinical and experimental study. J Bone Joint Surg [Am] 29: 381Google Scholar
- 4.Arora BK, Lastain DM (1964) Sex chromatin as a cellular label of osteogenesis by bone grafts. J Bone Joint Surg [Am] 46A: 1269Google Scholar
- 6.Deleu J, Truets J (1965) Vascularization of bone grafts in the anterior chamber of the eye. J Bone Joint Surg [Am] 47: 319–329Google Scholar
- 7.Enneking WF, Burchardt H, Prehl JJ et al. (1975) Physical and biological aspects of repair in dog cortical bone transplants. J Bone Joint Surg [Am] 57A: 232Google Scholar
- 8.Enneking WF, Eady J, Burchardt H (1980) Autogenous cortical bone grafts in the reconstruction of segmental skeletal defects. J Bone Joint Surg [Am] 62A: 1039Google Scholar
- 9.Richany SF, Sprinz H, Kraner K et al. (1965) The role of the diaphyseal medulla in the repair and regeneration of the femoral shaft in the adult cart. J Bone Joint Surg [Am] 47A: 1565Google Scholar