The Role of Histocompatibility in Bone Allografting

  • V. M. Goldberg
  • A. Powell
  • J. W. Shaffer
  • J. Zika
  • S. Stevenson
  • D. Davy
  • K. Heiple
Conference paper


Clinical and experimental studies of large nonvascular osteochondral allografts and autografts suggest that they ultimately fail because of incomplete and inadequate revascularization and mineralization [4, 10, 15, 20]. It has been shown that bone allografts elicit an immune response by the host [2, 7, 12, 19] Immune responses to fresh cancellous allografts are greater than to cortical bone and greater than to frozen or freeze-dried bone [7]. However, there still is controversy concerning the role of the immune system and the ultimate clinical outcome of bone allografts [10]. Since bone conforms to transplantation biology it would appear logical that transplantation antigens (histocompatibility) are important determinants of the success or failure of bone allografting.


Prussian Blue Bone Allograft Osteochondral Allograft Vascularized Bone Graft Vascularized Fibular Graft 
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Copyright information

© Springer-Verlag, Berlin Heidelberg 1989

Authors and Affiliations

  • V. M. Goldberg
    • 1
  • A. Powell
    • 1
  • J. W. Shaffer
    • 1
  • J. Zika
    • 1
  • S. Stevenson
    • 1
  • D. Davy
    • 1
  • K. Heiple
    • 1
  1. 1.Departments of Orthopedics and SurgeryCase Western Reserve UniversityClevelandUSA

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