Extracorporal Plasma Therapy in the Treatment of Severe Hyper-β-lipoproteinemia: The HELP System

  • D. Seidel
Conference paper
Part of the Supplement zu den Sitzungsberichten der Mathematisch-naturwissenschaftlichen Klasse Jahrgang 1988 book series (HD AKAD, volume 1988 / 1988/2)


A large and convincing body of evidence links coronary risk with elevated plasma levels of both low-density lipoprotein (LDL) cholesterol and fibrinogen. Cholesterol in atherosclerotic lesions originates mainly from cholesterol circulating in the blood bound to LDL. Most forms of hyper-β-lipoproteinemia result from a defect in extraction of LDL from plasma by the liver, and the LDL receptor is now being recognized as the crucial element in the control of cholesterol homeostasis [1]. Elevated levels of fibrinogen, a common phenomenon in hypercholesterolemia increases the viscosity of the blood and thereby further alters perfusion of tissues in severe atherosclerotic disease. Furthermore, fibrinogen and its degradation products can both influence prostaglandin metabolism by inhibiting PGI2 synthesis by endothelial and vascular smooth muscle cells, thereby facilitating platelet aggregation, and can also cause injury to endothelial cells.


Familial Hypercholesterolemia Elevated Plasma Level Erythrocyte Filtration Severe Atherosclerotic Disease Precipitation Chamber 
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  1. 1.
    Goldstein JL, Brown MS (1983) Familial hypercholesterolemia. In: Stanbury JB, Wyngaarden JB, Frederickson DS, Goldstein JL, Brown MS (eds) The metabolic basis of inherited disease, 5th edn. McGraw Hill, New YorkGoogle Scholar
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    Seidel D, Wieland H (1982) Ein neues Verfahren zur selektiven Messung und extrakorporalen Elimination von Low Density Lipoproteinen. J Clin Chem Clin Biochem 20: 684–685Google Scholar
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    Eisenhauer T, Armstrong VW, Wieland H, Fuchs C, Scheler F, Seidel D (1987) Selective removal of low density lipoproteins (LDL) by precipitation at low pH: first clinical application of the HELP system. Klin Wochenschr 65: 161–168PubMedCrossRefGoogle Scholar

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© Springer-Verlag Berlin Heidelberg 1988

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  • D. Seidel

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