Abstract
Suckling mice injected intraperitoneally with 6-aminonicotinamide (6-AN) in one dose of 25 mg/kg body weight consistently develop enlargement of the head 7–9 days after injection (Aikawa and Suzuki 1985a, 1986). In coronal sections of the cerebrum, marked hydrocephalus is evident due to dilatation of the lateral ventricles (Fig. 57). The fourth ventricle is not dilated and the aqueduct is always narrowed and obliterated (Aikawa et al. 1984). No hydrocephalus is seen in adult mice treated with 6-AN.
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Aikawa, H., Suzuki, K. (1988). Neurotoxic Effects of 6-Aminonicotinamide, Mouse. In: Jones, T.C., Mohr, U., Hunt, R.D. (eds) Nervous System. Monographs on Pathology of Laboratory Animals. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-83516-2_9
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DOI: https://doi.org/10.1007/978-3-642-83516-2_9
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