Skip to main content
SpringerLink
Log in

Overview of Clinical Trials and Basis for Future Therapies

  • Chapter
Radiation Therapy of Head and Neck Cancer

Part of the book series: Medical Radiology ((Med Radiol Radiat Oncol))

Abstract

The development of a research strategy investigating new approaches to the treatment of advanced head and neck cancers requires an extensive and complete data base. One must know the rate and pattern of distant metastasis and local treatment failure (how standard treatment fails) before one can develop new treatments. In order to develop such a data base, the Radiation Therapy Oncology Group (RTOG) established a prospective registry for head and neck cancer in 1977. Between February 1977 and April 1980, the following information was collected on all head and neck cancers treated at RTOG institutions: primary tumor site, T-stage, N-stage, M-stage, age, sex, Karnofsky performance score, tumor histology, tumor differentiation, extent of infiltration, treatment delivery, and outcome. All patients were staged according to the 1976 TNM staging system of the American Joint Committee for Cancer Staging and End Results Reporting. 2066 cases were entered into the registry. 992 of these had locally advanced inoperable disease treated by radiation therapy alone. The sites of treatment failure, including distant metastatic rates, were established for that group of patients.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Amer MH, Al-Sarraf M, Vaitkevicious M (1979) Factors that affect response to chemotherapy and survival of patients with advanced head and neck cancer. Cancer 43: 2202–2206

    Article  PubMed  CAS  Google Scholar 

  • Amrein PC, Figert H, Weitzman SA (1983) Cisplatin-vincristine-bleomycin therapy in squamous cell carcinoma of the head and neck. J Clin Oncol 1: 421–427

    PubMed  CAS  Google Scholar 

  • Amrein PC, Weitzman SA (1985) Treatment of squamous cell carcinoma of the head and neck with cisplatin and 5-fluorouracil. J Clin Oncol 3:1632–1639

    PubMed  CAS  Google Scholar 

  • Ansfield FJ, Ramirez G, Davis HL, Korbitz BC, Vermund H, Gollin FF (1970) Treatment of advanced cancer of the head and neck. Cancer 25: 78–82

    Article  PubMed  CAS  Google Scholar 

  • Batterman JJ, Breuer K (1981) Results of fast neutron teletherapy for locally advanced head and neck tumors. Int J Radiat Oncol Biol Phys 7:1045–1056

    Article  Google Scholar 

  • Batterman JJ, Breuer K, Hart BAM et al. (1981) Observations on pulmonary metastases in patients after single doses and multiple fractions of fast neutrons and cobalt-60 gamma rays. Eur J Cancer 17: 539–545

    Article  Google Scholar 

  • Boman BM, Moertel CG, O’Connell MJ, Scott M, Weiland LH, Beart RW, Gunderson LL, Spencer RJ (1984) Carcinoma of the anal canal. A clinical and pathologic study of 188 cases. Cancer 54: 114–125

    Article  PubMed  CAS  Google Scholar 

  • Borthne A, Kjellevold K, Kaalhus O, Vermund H (1986) Salivary gland malignant neoplasms: treatment and prognosis. Int J Radiat Oncol Biol Phys 12: 741–754

    Article  Google Scholar 

  • Brennan JT, Phillips TL (1971) Evaluation of past experience with fast neutron teletherapy and its implications for future applications. Eur J Cancer 7: 219–234

    Article  PubMed  CAS  Google Scholar 

  • Cachin Y, Jortay A, Sancho H, Eschwege F, Madelain M (1977) Preliminary results of a randomized EORTC study comparing radiotherapy and concomitant bleomycin to radiotherapy alone in epidermoid carcinomas of the oropharynx. Europ J Cancer 13:1389–1395

    Article  CAS  Google Scholar 

  • Cancer Treatment Symposia (1985) (Table 16-7)

    Google Scholar 

  • Carter SK (1977) The chemotherapy of head and neck cancer: Semin Oncol 4: 413–424

    PubMed  CAS  Google Scholar 

  • Catterall M, Bewley DK (1973) Fast neutrons in the treatment of cancer, pp 14–27. London, Academic Press

    Google Scholar 

  • Catterall M (1974) The treatment of advanced cancer by fast neutrons from the Medical Research Council’s cyclotron at Hammersmith Hospital, London. Eur J Cancer 10: 343–449

    Article  CAS  Google Scholar 

  • Catterall M, Bewley DK, Sutherland I (1977) Second report on a randomized clinical trial of fast neutrons with X or gamma rays in the treatment of advanced cancers of the head and neck. Br Med J 1: 1942–1954

    Google Scholar 

  • Catterall M (1981) The treatment of malignant salivary gland tumors with fast neutrons. Int J Radiat Oncol Biol Phys 7: 1737–1745

    Article  PubMed  CAS  Google Scholar 

  • Decker DA, Dreilichman A, Jacobs J, Hoschner J, Dinzie J, Loh JJK, Weaver A, Al-Sarraf M (1983) Adjuvant chemotherapy with cis-diamminodichloroplatinum II and 120-hour infusion 5-fluorouracil in Stages III and IV squamous cell carcinoma of the head and neck. Cancer 51: 1353–1355

    Article  PubMed  CAS  Google Scholar 

  • DeConti RC, Schoenfeld D (1981) A randomized prospective comparison of intermittent methotrexate, methotrexate with leukovorin and methotrexate combination in head and neck cancer. Cancer 48: 1061–1072

    Article  PubMed  CAS  Google Scholar 

  • Del Rowe J, Pajak TF, Davis LW, Brady L, Mohiuddin M, Rubin P, Marcial V, Stetz J (in press) The role of distant metastasis as a site of failure in cancers of the head and neck region. Int J Radiat Oncol Biol Phys

    Google Scholar 

  • Dobrowsky W, Schlappack O, Karcher KH, Pavelka R, Kment G (1986) Electron beam therapy in treatment of parotid neoplasm. Radiother Oncol 6: 293–299

    Article  PubMed  CAS  Google Scholar 

  • Drelichman A, Cummings G, Al-Sarraf M (1983) A randomized trial of the combination of cis-platinum, oncovin and bleomycin vs methotrexate in patients with advanced squamous cell carcinoma of the head and neck. Cancer 52: 399–403

    Article  PubMed  CAS  Google Scholar 

  • Duncan W, Arnott SJ, Orr JA et al. (1982) The Edinburgh experience of fast neutron therapy. Int J Radiat Oncol Biol Phys 8: 2155–2164

    Article  PubMed  CAS  Google Scholar 

  • Duncan W, Arnott SJ, Batterman JJ et al. (1984) Fast neutrons in the treatment of advanced head and neck cancers: the results of a multi-centre randomly controlled trial. Radiother Oncol 2: 293–305

    Article  PubMed  CAS  Google Scholar 

  • Duncan W, Orr JA, Arnott SJ, Jack WJC (1987) Neutron therapy for malignant tumors of the salivary glands: a report of the Edinburgh experience. Radiother One 8: 97–104

    Article  CAS  Google Scholar 

  • Eichhorn HJ (1981) Pilot study on the applicability of neutron radiotherapy. Radiobiol Radiother 3: 262–292

    Google Scholar 

  • Elkon R, Colman J, Hendrickson FR (1928) Radiation therapy in the treatment of malignant salivary gland tumors. Cancer 41:502–506

    Article  Google Scholar 

  • Ervin TJ, Miller D, Weichselbaum R, Fabian RL, Meshad M (1981) Chemotherapy for advanced carcinoma of the head and neck. Arch Otolaryng 107: 237–241

    Article  PubMed  CAS  Google Scholar 

  • Fitzpatrick PJ, Theriault C (1986) Malignant salivary gland tumors. Int J Radiat Oncol Biol Phys 12: 1743–1747

    Article  PubMed  CAS  Google Scholar 

  • Fu KK, Leibel SA, Levine MG et al. (1977) Carcinoma of the major and minor salivary glands: analysis of treatment results and sites and causes of failure. Cancer 40: 2882–2889

    Article  PubMed  CAS  Google Scholar 

  • Fu KK (1985) Biologic basis for the interaction of chemotherapeutic agents and radiation therapy. Cancer 55: 2123–2130

    Article  PubMed  CAS  Google Scholar 

  • Fu KK, Phillips TL, Silverberg IJ, Jacobs C, Chun C, Friedman MA, Kohler M, McWhirter K, Carter SK (1986) Combined radiotherapy and chemotherapy with bleomycin and methotrexate for advanced inoperable head and neck cancer: update of a Northern California Oncology Group (NCOG) randomized trial. Proc ASCO 5: 145–153

    Google Scholar 

  • Fu KK, Phillips TL, Silverberg IJ, Jacobs C, Goffinet DR, Chun C, Friedman MA, Kohler M, McWhirter K, Carter SK (1987) Combined radiotherapy and chemotherapy with bleomycin and methotrexate for advanced inoperable head and neck cancer: update of a Northern California Oncology Group randomized trial. J Clin Oncol 5: 1410–1418

    PubMed  CAS  Google Scholar 

  • Goldstein LS, Phillips TL, Fu KK (1981) Biological effects of accelerated heavy ions. I. Single doses in normal tissues, tumors and cells in vitro. Radiat Res 86: 529–541

    Article  PubMed  CAS  Google Scholar 

  • Gollin FF, Ansfield FJ, Brandenburg JH, Ramirez G, Vermund H (1972) Combined therapy in advanced head and neck cancer: a randomized study. Rad Ther & Nucl Med 114:83–88

    CAS  Google Scholar 

  • Gragg RL, Humphrey RM, Meyn RE (1977) The response of Chinese hamster ovary cells to fast neutron radiotherapy beams. II. Sublethal potentially lethal damage recovery capabilities. Radiat Res 71: 461–469

    Article  PubMed  CAS  Google Scholar 

  • Gragg RL, Humphrey RM, Thomas HW et al. (1978) The response of Chinese hamster ovary cells to fast neutron radiotherapy beams. I. Variations in RBE with position in the cell cycle. Radiat Res 76: 283–294

    Article  PubMed  CAS  Google Scholar 

  • Gray LH, Conger AE, Ebert M et al. (1953) Concentration of oxygen dissolved in tissues at time of irradiation as factor in radiotherapy. Br J Radiol 26: 638–646

    Article  PubMed  CAS  Google Scholar 

  • Griffin BR, Laramore GE, Griffin TW, Eenmaa J (in press) Fast neutron radiotherapy for advanced malignant salivary gland tumors. Cancer

    Google Scholar 

  • Griffin TW, Laramore GE, Parker RG, Gerdes AJ, Hebard DW, Blasko JC, Groudine MT (1978) An evaluation of fast neutron beam teletherapy of metastatic cervical adenopathy from squamous cell carcinomas of the head and neck region. Cancer 42: 2517–2520

    Article  PubMed  CAS  Google Scholar 

  • Griffin TW, Blasko JC, Laramore GE (1979) Results of fast neutron beam pilot studies at the University of Washington. Eur J Cancer (Suppl): 23–29

    Google Scholar 

  • Griffin TW, Davis R, Laramore GE, Hussey DH, Hendrickson FR, Rodriguez-Antunez A (1983) Fast neutron irradiation of metastatic cervical adenopathy: the results of a randomized RTOG study. Int J Radiat Oncol Biol Phys 9: 1267–1270

    Article  PubMed  CAS  Google Scholar 

  • Griffin TW, Davis R, Hendrickson FR (1984) Fast neutron radiation therapy for unresectable squamous cell carcinomas of the head and neck: the results of a randomized RTOG study. Int J Radiat Oncol Biol Phys 10: 2217–2221

    Article  PubMed  CAS  Google Scholar 

  • Haas C, Anderson T, Byhardt R, Cox J, Duncavage J, Grossman T, Haas J, Libnoch J, Malin T, Ritch P, Toohill R (1986) Randomized neo-adjuvant study of 5-fluorouracil and cis-platinum for patients with advanced resectable head and neck squamous cancer. Proc AACR 27:185–198

    Google Scholar 

  • Hall EJ, Kraljevic J (1976) Repair of potentially lethal radiation damage: comparison of neutron and X-ray RBE and implications for radiation therapy. Radiology 121: 731–749

    PubMed  CAS  Google Scholar 

  • Hall EJ (1978) Radiobiology for the Radiologist, Ed 2. Hagerstown, Maryland, Harper & Row

    Google Scholar 

  • Head and Neck Contract Program (1987) Adjuvant chemotherapy for advanced head and neck squamous carcinoma: final report of the head and neck contracts program. Cancer 60:301–311

    Article  Google Scholar 

  • Henry LW, Blasko JC, Griffin TW (1979) Evaluation of fast neutron teletherapy for advanced carcinomas of the major salivary glands. Cancer 44: 814–818

    Article  PubMed  CAS  Google Scholar 

  • Hill BT, Price LA, MacRae K (1986) Importance of primary site in assessing chemotherapy response and 7-year survival data in advanced squamous cell carcinomas of the head and neck treated with initial combination chemotherapy without cisplatin. J Clin Oncol 4:1340–1347

    PubMed  CAS  Google Scholar 

  • Hong WK, Shapshay SM, Bhutani R, Craft ML, Ucmakli A, Yamaguchi KT, Vaughn CW, Strong MS (1979) Induction chemotherapy in advanced squamous head and neck carcinoma with high dose cis-platinum and bleomycin infusion. Cancer 44:19–25

    Article  PubMed  CAS  Google Scholar 

  • Hong WK, Schaefer S, Issell B, Cummings C, Luedke D, Bromer R, Fofonoff S, D’Aoust J, Shapshay S, Welch J, Levin E, Vincent M, Vaughan C, Strong S (1983) A prospective randomized trial of methotrexate vs cisplatin in the treatment of recurrent squamous cell carcinoma of the head and neck. Cancer 52: 206–210

    Article  PubMed  CAS  Google Scholar 

  • Hong WK, Bromer RH, Amato DA, Shapshay S, Vincent M, Vaughn C, Willett B, Katz A, Welch J, Fofonoff S, Strong S (1985) Patterns of relapse in locally advanced head and neck cancer patients who achieve complete remission after combined modality therapy. Cancer 56:1242–1245

    Article  PubMed  CAS  Google Scholar 

  • Howlett JF, Thomlinson RH, Alper T (1975) A marked dependence of the conformative effective causes of neutrons on tumor line and its implications for clinical trials. Br J Radiol 48: 40–46

    Article  PubMed  CAS  Google Scholar 

  • Jacobs C, Meyers F, Hendrickson C, Kohler M, Carter S (1983) A randomized Phase III study of cisplatin with or without methotrexate for recurrent squamous cell carcinoma of the head and neck. Cancer 52:1563–1569

    Article  PubMed  CAS  Google Scholar 

  • Kaul R, Hendrickson F, Cohen L, Rosenberg I, Haken RT, Awschalom M, Mansell J (1981) Fast neutrons in the treatment of salivary gland tumors. Int J Radiat Oncol Biol Phys 7:1667–1675

    Article  PubMed  CAS  Google Scholar 

  • Kies MS, Hauck WW, Gordon LI, Krespi Y, Ossoff RH, Pecaro BC, Yuska C, Lamut CH, Brand WN, Chang SK, Shetty R, Sisson GA (1985) Analysis of complete responded after initial treatment with chemotherapy in head and neck cancer. Oto Head & Neck Surg 93:199–205

    CAS  Google Scholar 

  • Kish JA, Ensley JF, Jacobs J, Weaver A, Cummings G, Al-Sarraf M (1985) A randomized trial of cisplatin (CACP) +5-fluorouracil infusion and CACP+5-FU bolus for recurrent and advanced squamous cell carcinoma of the head and neck. Cancer 56: 2740–2744

    Article  PubMed  CAS  Google Scholar 

  • Knowlton AH, Percarpio B, Bobrow S, Fischer JJ (1975) Methotrexate and radiation therapy in treatment of head and neck tumors. Radiology 116: 709–712

    PubMed  CAS  Google Scholar 

  • Krasnow SH, Cohen MH, Johnston-Early A, Citron ML, Fossieck BE, Mauk CM, Yenson A, Banda FP, Lunzer S, deFries HO (1984) Combined therapy for Stages II-IV head and neck cancer: preliminary results. J Clin Oncol 2: 804–810

    PubMed  CAS  Google Scholar 

  • Kun LE, Too hill RJ, Holoye PY, Duncavage JA, Byhardt RW, Ritch PS, Grossman TW, Hoffmann RF, Cox JD, Malin T (1986) A randomized study of adjuvant chemotherapy for cancer of the upper aerodigestive tract. J Radiat Oncol Biol Phys 12: 173–178

    CAS  Google Scholar 

  • Laramore GE. Griffin TW, Tesh DW, Wong HH, Parker RG (1983) Phase I pilot study on fast neutron teletherapy for advanced carcinoma of the head and neck region: final report on local control rate and survival. Cancer 51:192–199

    Article  PubMed  CAS  Google Scholar 

  • Leichman L, Nigro N, Vaitkevicius VK, Considine B, Buroker T, Bradley G, Seydel H, Olchowski S, Cummings G, Leichman C, Baker L (1985) Cancer of the anal canal. Model for preoperative adjuvant combined modality therapy. Am J Med 78:211–215

    Article  PubMed  CAS  Google Scholar 

  • Livingston RB, Carter SK (1970) Single agents in cancer chemotherapy. New York, Plenum Press, pp 1–405

    Google Scholar 

  • Lo TCM, Wiley AL, Ansfield FJ, Brandenburg JH, Davis HL, Gollin FF, Johnson RO, Ramirez G, Vermund H (1976) Combined radiation therapy and 5-fluorouracil for advanced squamous cell carcinoma of the oral cavity and oropharynx: a randomized study. 126: 229–235

    Google Scholar 

  • Maor MH, Hussey DH, Fletcher GH et al. (1981) Fast neutron therapy for locally advanced head and neck tumors. Int J Radiat Oncol Biol Phys 7: 155–173 (private communication also)

    Article  PubMed  CAS  Google Scholar 

  • Marcial VA, Pajak TF, Kramer S, Davis LW, Stetz J, Laramore GE, Brady LW (in press) Radiation therapy oncology group studies in head and neck cancer. Int J Radiat Oncol Biol Phys

    Google Scholar 

  • Million HR, Cassisi NJ, Wittes RE (1982) Cancer in the head and neck. In: Cancer: principles and practice of oncology. De Vita VY. Hellman S, Rosenberg SA (eds). Philadelphia, JB Lippincott Co, pp301–395

    Google Scholar 

  • Morita S, Tsunemoto H, Kurisu A et al. (1978) Results of fast neutron therapy at NIRS. Proc Fourth High LET Radiotherapy Seminar, pp 127-141

    Google Scholar 

  • Ornitz R, Herskovic A, Bradley E (1979) Clinical observations of early and late normal tissue injury and tumor control in patients receiving fast neutron irradiation. In: High LET radiations in clinical radiotherapy. Barendsen GW Broerse J Breur K (eds). New York, Pergamon Press, pp44–50

    Google Scholar 

  • Parsons JT, Cassisi NJ, Million RR (1984) Results of twice-aday irradiation of squamous cell carcinomas of the head and neck. Int J Radiat Oncol Biol Phys 10: 2041–2049

    Article  PubMed  CAS  Google Scholar 

  • Probert JC, Thompson RW, Bagshaw MA (1984) Patterns of spread and distant metastases in head and neck cancer. Cancer 33: 127–133

    Article  Google Scholar 

  • Rafla S (1977) Malignant parotid tumors: natural history and treatment. Cancer 40: 136–148

    Article  PubMed  CAS  Google Scholar 

  • Reddy EK, Mansfield CM, Hartman GV et al. (1979) Malignant salivary gland tumors: role of radiation therapy. JAMA 71:959–971

    CAS  Google Scholar 

  • Richards GJ, Chambers RG (1969) Hydroxyurea: a radiosensitizer in the treatment of neoplasms of the head and neck. Amer J Roentgenol 105: 555–565

    PubMed  Google Scholar 

  • Rooney M, Kish J, Jacobs J, Kinzie J, Weaver A, Crissman J, Al-Sarraf M (1985) Improved complete response rate and survival in advanced head and neck cancer after threecourse induction therapy with 120-hour 5-FU infusion and cisplatin. Cancer 55:1123–1128

    Article  PubMed  CAS  Google Scholar 

  • Rossman KJ (1975) The role of radiation therapy in the treatment of parotid carcinomas. Am J Radiol 123: 492–499

    CAS  Google Scholar 

  • Saroja KR, Mansell J, Hendrickson FR, Cohen L, Lennox A (1987) An update on malignant salivary gland tumors treated with neutrons at Fermilab. Int J Radiat Oncol Biol Phys 13:1319–1325

    Article  PubMed  CAS  Google Scholar 

  • Shapshay SM, Hong WK, Incze JS, Sismanis A, Bhutani R, Vaughn CW, Strong WS (1980) Prognostic indicators in induction cis-platinum-bleomycin chemotherapy for advanced head and neck cancer. Am J Surg 140: 543–547

    Article  PubMed  CAS  Google Scholar 

  • Shidnia H, Hornback NB, Hamaker R et al. (1980) Carcinoma of major salivary gland. Cancer 45: 693–699

    Article  PubMed  CAS  Google Scholar 

  • Skolyszewski J, Byrski E, Chrzanowski A, Gasinska A, Reinfus M, Huczkowski J, Lazarska B, Michalowski A, Meder J (1982) A preliminary report on the clinical application of fast neutrons in Krakow. Int J Radiat Oncol Biol Phys 8: 1781–1786

    Article  PubMed  CAS  Google Scholar 

  • Spaulding MB, Klotch D, Grillo J, Sanani S, Lore JM (1980) Adjuvant chemotherapy in the treatment of advanced tumors of the head and neck. Am J Surg 140: 538–542

    Article  PubMed  CAS  Google Scholar 

  • Spaulding M, Ziegler P, Sundquist N, Klotch D, Lee K, Khan A, Lore J (1986) Induction therapy in head and neck cancer. A comparison of two regimens. Cancer 57: 1110–1114

    CAS  Google Scholar 

  • Spaulding MB, Vasquez J, Khan A, Sundquist N, Lore JM (1983) A non-toxic adjuvant treatment for advanced head and neck cancer. Arch Otolaryngol 109: 789–791

    Article  PubMed  CAS  Google Scholar 

  • Stefani S, Eells RW, Abbate J (1971) Hydroxyurea and radiotherapy in head and neck cancer. Radiology 101: 391–396

    PubMed  CAS  Google Scholar 

  • Stewart JG, Jackson AW, Chew MK (1968) The role of radiation therapy in the management of malignant tumors of salivary glands. Am J Roentgenol 102: 100–112

    CAS  Google Scholar 

  • Stone RS (1940) Neutron therapy and specific ionization. Am J Roentgenol 59: 771–784

    Google Scholar 

  • Taylor SG, McGuire WP, Hauck WW, Showel JL, Lad TE (1984) A randomized comparison of high-dose infusion methotrexate vs standard-dose weekly therapy in head and neck squamous cancer. J Clin Oncol 2: 1006–1011

    PubMed  Google Scholar 

  • Taylor SG, Appelbaum E, Showel JL, Norusis M, Holinger LD, Hutchinson JC, Murthy AK, Caldarelli DD (1985) A randomized trial of adjuvant chemotherapy in head and neck cancer. J Clin Oncol 3: 672–679

    PubMed  Google Scholar 

  • Tubiana M, Arriagada R, Cosset J (1985) Sequencing of drugs and radiation. The integrated alternating regimen. Cancer 55:2131–2139

    Article  PubMed  CAS  Google Scholar 

  • Veronisi A, Zagonel V, Tirelli U, Galligioni E, Tumolo S, Barzan L, Lorenzini M, Comoretto R, Grigoletto E (1985) High-dose vs low-dose cisplatin in advanced head and neck squamous carcinoma: a randomized study. J Clin Oncol 3: 1105–1108

    Google Scholar 

  • Vikram B, Strung EW, Shah JP, Spiro RH (1984) Radiation therapy in adenoid-cystic carcinoma. Int J Radiat Oncol Biol Phys 10: 221–223

    Article  PubMed  CAS  Google Scholar 

  • Vogl SE, Schoenfeld DA, Kaplan BH, Lerner HJ, Engstrom PF, Horton J (1985) A randomized prospective comparison of methotrexate with a combination of methotrexate, bleomycin and cisplatin in head and neck cancer. Cancer 56: 432–442

    Article  PubMed  CAS  Google Scholar 

  • Wang CC, Suit HD, Phil D, Blitzer PH (1986) Twice-a-day radiation therapy for supraglottic carcinoma. Int J Radiat Oncol Biol Phys 12: 3–14

    Article  PubMed  CAS  Google Scholar 

  • Weichselbaum RR, Clark JR, Miller D, Posner MR, Ervin TJ (1985) Combined modality treatment of head and neck cancer with cisplatin, bleomycin, methotrexate-leukovorin chemotherapy. Cancer 55: 2149–2155

    Article  PubMed  CAS  Google Scholar 

  • Williams MV, Denekamp J, Fowler JF (1985) A review of a/ p ratios for experimental tumors: implications for clinical studies of altered fractionation. Int J Radiat Oncol Biol Phys 11: 87–95

    Article  PubMed  CAS  Google Scholar 

  • Williams SD, Velez-Garcia E, Essesse I, Ratkin G, Birch R, Einhorn LH (1986) Chemotherapy of head and neck cancer: comparison of cisplatin + vinblastine + bleomycin vs methotrexate. Cancer 57:18–23

    Article  PubMed  CAS  Google Scholar 

  • Withers HR, Thames HD, Peters LJ (1982) Biological bases for high RBE values for late effects of neutron irradiation. Int J Radiat Oncol Biol Phys 8: 2071–2082

    Article  PubMed  CAS  Google Scholar 

  • Withers HR, Thames HD, Peters LJ (1983) A new isoeffect curve for change in dose per fraction. Radiother & Oncol 1:187–198

    Article  CAS  Google Scholar 

  • Woolfe GT, Makuch RW, Baker SR (1984) Predictive factors for tumor response to preoperative chemotherapy in patients with head and neck squamous carcinoma. Cancer 54: 2869–2877

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Division of Medical Oncology, Department of Medicine, University of Washington Hospital/School of Medicine, Seattle, Washington, 98195, USA

    Thomas W. Griffin M.D. & Joanne Mortimer M.D.

Authors
  1. Thomas W. Griffin M.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Joanne Mortimer M.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Department of Radiation Oncology, University of Washington, School of Medicine and University Hospital, Seattle, WA, 98195, USA

    George E. Laramore Ph.D., M.D. (Professor of Radiation Oncology, Clinical Director) (Professor of Radiation Oncology, Clinical Director)

Rights and permissions

Reprints and permissions

Copyright information

© 1989 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Griffin, T.W., Mortimer, J. (1989). Overview of Clinical Trials and Basis for Future Therapies. In: Laramore, G.E. (eds) Radiation Therapy of Head and Neck Cancer. Medical Radiology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-83501-8_16

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-83501-8_16

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-83503-2

  • Online ISBN: 978-3-642-83501-8

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation