Skip to main content

Biologische Konzepte zur Ätiologie und Pathogenese der Schizophrenien — Eine Übersicht

  • Conference paper
  • 27 Accesses

Part of the book series: Tropon-Symposium ((BAYERZNS,volume 3))

Zusammenfassung

Bei der Beschäftigung mit biologischen Konzepten zur Ätiologie und Pathogenese der Schizophrenien wird man zunächst mit der erkenntnistheoretischen Frage nach den grundlegenden Beziehungen zwischen einer psychopathologisch fundierten Klassifikation der Erscheinungsformen und Subtypen der Schizophrenie einerseits und den Forschungsstrategien der exakten Naturwissenschaften andererseits konfrontiert. Da eine detaillierte Untersuchung dieses Problems den Rahmen der vorliegenden Übersicht bei weitem sprengen würde, sei auf die kürzlich erschienene Darstellung von Sass (1987) verwiesen, in der die angeschnittene Thematik Berücksichtigung findet.

This is a preview of subscription content, log in via an institution.

Buying options

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   54.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   69.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

  • Beckmann H, Gattaz WF, Jakob H (1987) Biochemical and neuropathological indices for the aetiology of schizophrenia. In: Häfner H, Gattaz WF, Janzarik W (eds) Search for the causes of schizophrenia. Springer, Berlin Heidelberg New York Tokyo, pp 241–249

    Chapter  Google Scholar 

  • Bleuler M (1972) Die schizophrenen Geistesstörungen im Lichte langjähriger Kranken- und Familiengeschichten. Thieme, Stuttgart

    Google Scholar 

  • Bloom F, Segal D, Ling N et al. (1976) Endorphin’s profound behavioral effects in rats suggest new etiological factors in mental illness. Science 194:630–632

    Article  PubMed  CAS  Google Scholar 

  • Carlsson A, Lindqvist M (1963) Effect of chlorpromazine or haloperidol on formation of 3-methoxytyramine and normetanephrine in mouse brain. Acta Pharmacol Toxicol 20:140–144

    Article  CAS  Google Scholar 

  • Carlsson A (1987) The dopamine hypothesis of schizophrenia 20 years later. In: Häfner H, Gattaz WF, Janzarik W (eds) Search for the causes of schizophrenia. Springer, Berlin Heidelberg New York Tokyo, pp 223–235

    Chapter  Google Scholar 

  • Chouinard G, Annable L, Horrobin DF (1978) An anti-psychotic action of penicillin on schizophrenia. IRCS J Med Sci 6:187–193

    Google Scholar 

  • Cross AJ, Crow TJ, Owen F (1981) H3-Flupenthixol binding in post-mortem brains of schizophrenics: Evidence for a selective increase in dopamine D2 receptors. Psychopharmacology 74:122–124

    Article  PubMed  CAS  Google Scholar 

  • Crow TJ (1984) A re-evaluation of the viral hypothesis: Is psychosis the result of retroviral integration at a site close to the cerebral dominance gene? Br J Psychiatry 145:243–253

    Article  PubMed  CAS  Google Scholar 

  • Crow TJ (1987) The retrovirus/transposon hypothesis of schizophrenia. In: Häfner H, Gattaz WF, Janzarik W (eds) Search for the causes of schizophrenia. Springer, Berlin Heidelberg New York Tokyo, pp 260–266

    Chapter  Google Scholar 

  • DiChiara G, Porceddu MAL, Vargiu L, Steffanini E, Gessa GL (1977) Evidence for selective and long-lasting stimulation of “regulatory” dopamine receptors by bromocriptine (CB145). Naunyn Schmiedebergs Arch Pharmacol 300:239–245

    CAS  Google Scholar 

  • Falkai P, Bogerts B (1986) Cell loss in the hippocampus of schizophrenics. Eur Arch Psychiatr Neurol Sci 236:154–161

    Article  CAS  Google Scholar 

  • Feldberg W (1976) Possible association of schizophrenia with a disturbance in prostaglandin metabolism. A physiological hypothesis. Psychol Med 6:359–369

    Article  PubMed  CAS  Google Scholar 

  • Flor-Henry P (1969) Psychosis and temporal lobe epilepsy: A controlled investigation. Epilepsie 10:363–395

    Article  CAS  Google Scholar 

  • Gattaz WF, Köllisch M (1986) Bromocriptine in the treatment of neuroleptic-resistant schizophrenia. Biol Psychiatry 21:519–521

    Article  PubMed  CAS  Google Scholar 

  • Gottesman JJ, Shields H (1982) Schizophrenia, the epigenetic puzzle. Cambridge University Press, Cambridge

    Google Scholar 

  • Gruzelier JH (1981) Cerebral laterality and psychopathology: Fact and Fiction. Psychol Med 113:219–227

    Article  Google Scholar 

  • Guenther W, Breitling D, Bauquet Y-P, Mareie P, Rondot P (1986) EEG mapping of left hemisphere dysfunction during motor performance in schizophrenia. Biol Psychiatry 21:249–262

    Article  PubMed  CAS  Google Scholar 

  • Gunne L-M, Lindström L, Terenius L (1977) Naloxone-induced reversal of schizophrenic hallucinations. J Neural Transm 40:13–19

    Article  PubMed  CAS  Google Scholar 

  • Gur R, Gur RC, Skolnick BE, Caroff S, Obrist WD, Resnick S, Reivich M (1985) Brain function in psychiatric disorders. III. Regional cerebral blood flow in unmedicated schizophrenics. Arch Gen Psychiatry 42:329–334

    Article  PubMed  CAS  Google Scholar 

  • Heston LL (1966) Psychiatric disorders in foster home reared children of schizophrenic mothers. Br J Psychiatry 112:819–827

    Article  PubMed  CAS  Google Scholar 

  • Higgins J (1976) Effects of child rearing by schizophrenic mothers: A follow-up. J Psychiat Res 13:1–11

    Article  PubMed  CAS  Google Scholar 

  • Horrobin DF (1977) Schizophrenia as a prostaglandin deficiency disease. Lancet 1:936–937

    Article  PubMed  CAS  Google Scholar 

  • Kaschka WP (1985 a) Klinisch-immunologische Untersuchungen bei neuropsychiatrischen Erkrankungen. Ein Beitrag zur Immunpathologie der Multiplen Sklerose, der Myasthenia gravis und der endogenen Psychosen. Thieme, Stuttgart

    Google Scholar 

  • Kaschka WP (1985 b) Biologische Hypothesen und Theorien zur Ätiopathogenese der Schizophrenie. Nervenheilkunde 4:260–264

    Google Scholar 

  • Kebabian JW, Calne DB (1979) Multiple receptors for dopamine. Nature 277:93–96

    Article  PubMed  CAS  Google Scholar 

  • Kim JS, Kornhuber HH, Schmid-Burgk W, Holzmüller B (1980) Low cerebrospinal fluid glutamate in schizophrenic patients and a new hypothesis on schizophrenia. Neurosci Lett 20:379–382

    Article  PubMed  CAS  Google Scholar 

  • Kringlen E (1987) Contributions of genetic studies on schizophrenia. In: Häfner H, Gattaz WF, Janzarik W (eds) Search for the causes of schizophrenia. Springer, Berlin Heidelberg New York Tokyo, pp 123–142

    Chapter  Google Scholar 

  • McGuffin P, Farmer AE, Gottesman JJ (1987) Modern diagnostic criteria and genetic studies of schizophrenia. In: Häfner H, Gattaz WF, Janzarik W (eds) Search for the causes of schizophrenia. Springer, Berlin Heidelberg New York Tokyo, pp 143–156

    Chapter  Google Scholar 

  • Negele J, Sauerbrei W, Kaschka WP (1988) Immunologische und virologische Befunde bei psychiatrischen Erkrankungen. In: Beckmann H, Laux G (Hrsg) Biologische Psychiatrie-Synopsis 1986/87. Springer, Berlin Heidelberg New York Tokyo

    Google Scholar 

  • Randrup A, Munkvad I (1967) Stereotyped activities produced by amphetamine in several animal species and man. Psychopharmacologia 11:300–310

    Article  PubMed  CAS  Google Scholar 

  • Reynolds GP (1983) Increased concentrations and lateral asymmetry of amygdala dopamine in schizophrenia. Nature 305:527–529

    Article  PubMed  CAS  Google Scholar 

  • Reynolds GP (1987) Postmortem neurochemical studies in schizophrenia. In: Häfner H, Gattaz WF, Janzarik W (eds) Search for the causes of schizophrenia. Springer, Berlin Heidelberg New York Tokyo, pp 236–240

    Chapter  Google Scholar 

  • Rosenthal D (1972) Three adoption studies of heredity in the schizophrenic disorders. Int J Ment Health 1:63–72

    Google Scholar 

  • Sass H (1987) The classification of schizophrenia in the different diagnostic systems. In: Häfner H, Gattaz WF, Janzarik W (eds) Search for the causes of schizophrenia. Springer, Berlin Heidelberg New York, Tokyo, pp 19–28

    Chapter  Google Scholar 

  • Scheid KF (1937) Febrile Episoden bei Schizophrenen. Thieme, Leipzig

    Google Scholar 

  • Seeman P, Ulpian C, Bergeron C et al. (1984) Bimodal distribution of dopamine receptor densities in brains of schizophrenics. Science 225:728–731

    Article  PubMed  CAS  Google Scholar 

  • Sheppard G, Gruzelier J, Manchanda R, Hirsch SR, Wise R, Frackowiak R, Jones T (1983) 15O positron emission tomographic scanning in predominantly never-treated acute schizophrenic patients. Lancet 11:1448–1452

    Article  Google Scholar 

  • Terenius L, Wahlström A, Lindström L, Widerlov E (1976) Increased CSF levels of endorphins in chronic psychoses. Neurosci Lett 3:157–162

    Article  PubMed  CAS  Google Scholar 

  • Verhoeven WMA, Ree JM van, Heezins-van Bentum A, Wied D de, Praag HM van (1982) Antipsychotic properties of des-enkephalin-endorphin in treatment of schizophrenic patients. Arch Gen Psychiatry 39:648–654

    Article  PubMed  CAS  Google Scholar 

Download references

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1988 Springer-Verlag Berlin Heidelberg

About this paper

Cite this paper

Kaschka, W.P. (1988). Biologische Konzepte zur Ätiologie und Pathogenese der Schizophrenien — Eine Übersicht. In: Kaschka, W.P., Joraschky, P., Lungershausen, E. (eds) Die Schizophrenien. Tropon-Symposium, vol 3. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-83488-2_1

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-83488-2_1

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-19290-9

  • Online ISBN: 978-3-642-83488-2

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics