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Malignant Lymphomas in Patients with or at Risk for AIDS in Italy

  • Conference paper
AIDS-Related Neoplasias

Part of the book series: Recent Results in Cancer Research ((RECENTCANCER,volume 112))

Abstract

Besides Kaposi’s sarcoma and other tumors such as the squamous carcinoma of the tongue and the cloacogenic carcinoma of the anorectum [2, 5, 6, 9,10,11,12, 19, 21, 23, 24] malignant lymphomas have been shown to be one of the major problems among the neoplastic complications of the acquired immunodeficiency syndrome (AIDS) [1, 7, 14, 15, 17, 26, 29, 30]. According to North American experience, non-Hodgkin’s lymphomas in patients with AIDS or with AIDS-related clinical conditions present at an advanced stage, concentrated in extranodal and often unusual locations, notably in the central nervous system (CNS). Disease confined to the lymph nodes is uncommon. These lymphomas are predominantly high-grade B-cell neoplasms classified as immunoblastic, lymphoblastic, and Burkitt-like lymphomas. A variety of severe opportunistic infections and Kaposi’s sarcoma affects these patients. The association with AIDS is strengthened by the regular demonstration of reversed ratios of helper (T4+) and suppressor (T8+) lymphocytes in the peripheral blood and by the presence of antibodies to HIV [8]. The prognosis is dismal: response to chemotherapy does not positively affect median survival. Mortality rates analyzed according to histological grade are higher than the currently reported rates in other comparable patient populations [30].

Partially supported by a grant of the Associazione Italiana per la Ricerca sul Cancro and by a grant of the Regione Friuli-Venezia Giulia.

For the Italian Cooperative AIDS & Tumor Group (GICAT): U. Tirelli (Pordenone), E. Vaccher (Pordenone), G. Ambrosini (Trento), A. Andriani (Roma), R. Barbieri (Milano), I. Bianco Silvestroni (Roma), G. Broccia (Cagliari), T. Chisesi (Vicenza), G. Fassio (Bergamo), M. Gobbi (Bologna), F. M. Gritti (Bologna), G. Lambertenghi Deliliers (Milano), F. Lanza (Ferrara), A. Lazzarin (Milano), F. Lombardi (Milano), G. Luzi (Roma), C. Malleo (Palermo), F. Mandelli (Roma), G. Mariani (Roma), R. Maserati (Pavia), E. A. Parrinello (Verona), N. Piersantelli (Genova), R. Proto (Brindisi), F. Puppo (Genova), G. Rezza (Roma), A.M.Rosci (Roma), G. Rossi (Brescia), A. Sinicco (Torino), A. Tognetti (Pisa), F. Gavosto (Torino), R. Foà (Torino).

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Author information

Authors and Affiliations

  1. Division of Medical Oncology, Centro di Riferimento Oncologico, Via Pedemontana Occidentale, 33081, Aviano (Pordenone), Italy

    S. Monfardini

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  1. S. Monfardini
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Editors and Affiliations

  1. Medizinische Klinik C, Kantonsspital St. Gallen, 9007, St. Gallen, Switzerland

    Luzius Schmid  & Hans-Jörg Senn  & 

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© 1988 Springer-Verlag Berlin · Heidelberg

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Monfardini, S. (1988). Malignant Lymphomas in Patients with or at Risk for AIDS in Italy. In: Schmid, L., Senn, HJ. (eds) AIDS-Related Neoplasias. Recent Results in Cancer Research, vol 112. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-83470-7_5

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  • DOI: https://doi.org/10.1007/978-3-642-83470-7_5

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-83472-1

  • Online ISBN: 978-3-642-83470-7

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