AIDS-Related Kaposi’s Sarcoma

  • A. E. Friedman-Kien
Conference paper
Part of the Recent Results in Cancer Research book series (RECENTCANCER, volume 112)

Abstract

An unusually disseminated, aggressive form of Kaposi’s sarcoma and Pneumocystis carinii pneumonia, a rare “opportunistic” infection, have remained, respectively, the most frequently observed neoplastic and infectious manifestations of the acquired immune deficiency syndrome (AIDS) in the United States and Europe since the beginning of the epidemic [1, 2]. Twenty-six cases of what is now known as AIDS-associated Kaposi’s sarcoma were first seen in homosexual and bisexual men in New York City and California between November 1979 and April 1981 [3]. At the same time in Los Angeles five cases of P. carinii pneumonia were also reported in young homosexual men [1]. Kaposi’s sarcoma, P. carinii pneumonia, and other live-threatening opportunistic infections were previously known to occur in association with diseases involving defective cell-mediated immunity as seen in patients with congenital immunodeficiencies, lymphoreticular malignancies, renal transplant recipients, and other patients receiving immunosuppressive therapy [4]. The sudden epidemic occurrence of Kaposi’s sarcoma and unusual opportunistic infections among previously “healthy” individuals who had no recognizable cause of immunosuppression suggested a common, underlying acquired immunologic disorder and eventually led to the realization that a new epidemic, now called AIDS, was on the horizon. Within a few months similar cases were seen among intravenous drug abusers and eventually in hemophiliacs and other recipients of blood products and blood transfusions.

Keywords

Pneumonia Dementia Nitrite Sarcoma Interferon 

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Copyright information

© Springer-Verlag Berlin · Heidelberg 1988

Authors and Affiliations

  • A. E. Friedman-Kien
    • 1
  1. 1.Department of Dermatology and MicrobiologyNew York University Medical CenterNew YorkUSA

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