AIDS-Related Kaposi’s Sarcoma

  • A. E. Friedman-Kien
Conference paper
Part of the Recent Results in Cancer Research book series (RECENTCANCER, volume 112)


An unusually disseminated, aggressive form of Kaposi’s sarcoma and Pneumocystis carinii pneumonia, a rare “opportunistic” infection, have remained, respectively, the most frequently observed neoplastic and infectious manifestations of the acquired immune deficiency syndrome (AIDS) in the United States and Europe since the beginning of the epidemic [1, 2]. Twenty-six cases of what is now known as AIDS-associated Kaposi’s sarcoma were first seen in homosexual and bisexual men in New York City and California between November 1979 and April 1981 [3]. At the same time in Los Angeles five cases of P. carinii pneumonia were also reported in young homosexual men [1]. Kaposi’s sarcoma, P. carinii pneumonia, and other live-threatening opportunistic infections were previously known to occur in association with diseases involving defective cell-mediated immunity as seen in patients with congenital immunodeficiencies, lymphoreticular malignancies, renal transplant recipients, and other patients receiving immunosuppressive therapy [4]. The sudden epidemic occurrence of Kaposi’s sarcoma and unusual opportunistic infections among previously “healthy” individuals who had no recognizable cause of immunosuppression suggested a common, underlying acquired immunologic disorder and eventually led to the realization that a new epidemic, now called AIDS, was on the horizon. Within a few months similar cases were seen among intravenous drug abusers and eventually in hemophiliacs and other recipients of blood products and blood transfusions.


Acquire Immune Deficiency Syndrome Homosexual Male Acquire Immune Deficiency Syndrome Patient Intravenous Drug Abuser Acquire Immune Deficiency Syndrome Case 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Centers for Disease Control (1981) Pneumocystis pneumonia. MMWR 30: 250–252Google Scholar
  2. 2.
    Centers for Disease Control (1981) Follow-up on Kaposi’s sarcoma and Pneumocystis pneumonia. MMWR 30: 409Google Scholar
  3. 3.
    Friedman-Kien AE, Laubenstein L, Marmor M et al. (1981) Kaposi’s sarcoma and pneumocystis pneumonia among homosexual men – New York and California. MMWR 30: 250–252Google Scholar
  4. 4.
    Krigel RL, Friedman-Kien AE (1985) Kaposi’s sarcoma in AIDS. In: DeVita VT, Hellman S, Rosenberg SA (eds) AIDS: etiology, diagnosis, treatment and prevention. Lippincott, New YorkGoogle Scholar
  5. 5.
    Haverkos HW (1987) Factors associated with the pathogenesis of AIDS (1987) J Infect Dis 156: 251–257PubMedCrossRefGoogle Scholar
  6. 6.
    Kaposi M (1872) Idiopathisches multiples Pigment-Sarkom der Haut. Arch Dermatol Syphil 4: 265–272CrossRefGoogle Scholar
  7. 7.
    Safai B (1984) Kaposi’s sarcoma: a review of the classical and endemic forms. Ann NY Acad Sci 437: 373–381PubMedCrossRefGoogle Scholar
  8. 8.
    Templeton AC (1976) Kaposi’s sarcoma. In: Andrade R, Gumport SL, Popkin GL, Rees (eds) Cancer of the skin, vol 2. Saunders, Philadelphia, pp 1183–1225Google Scholar
  9. 9.
    Harwood A, Osoba D, Hofstader M, Goldstein C et al (1979) Kaposi’s sarcoma in recipients of renal transplants. Am J Med 67: 759–765PubMedCrossRefGoogle Scholar
  10. 10.
    Haverkos HW (1981) Kaposi’s sarcoma and nitrite inhalants. Adv Biochem Therap (in press)Google Scholar
  11. 11.
    Ziegler JL, Abrams DI (1985) In: DeVitaVT, Hellman S, Rosenberg SA (eds) AIDS: etiology, diagnosis, treatment and prevention. Lippincott, Philadelphia, pp 223–233Google Scholar
  12. 12.
    Friedman-Kien AE, Laubenstein L, Rubinstein P et al. (1982) Disseminated Kaposi’s sarcoma in homosexual men. Ann Intern Med 96(I): 693–700PubMedGoogle Scholar
  13. 13.
    Friedman-Kien AE, Greene J (1984) Aquired Immune Deficiency Syndrome. In: Petersdorf RG, Adams RD, Brouswald E, Isselbacher KJ, Marttin JB, Wilson JD (eds) Harrison’s principles of internal medicine update, vol IV. Mc Graw Hill, New York (1986)Google Scholar
  14. 14.
    Navia BA, Jordan BD, Price RW (1986) The AIDS dementia complex: I. clinical features. Ann Neurol 19: 517–524PubMedCrossRefGoogle Scholar
  15. 15.
    Friedman-Kien AE, Ostreicher R (1984) Overview of classical and epidemic Kaposi’s sarcoma. In Friedman-Kien AE, Laubenstein LJ (eds) AIDS: the epidemic of Kaposi’s sarcoma and opportunistic infections. Masson, New York, pp 23–34Google Scholar
  16. 16.
    Horowitz L, Stern JO, Segarra S (1984) Gastrointestinal manifestations of Kaposi’s sarcoma and AIDS. In: Friedman-Kien AE, Laubenstein LJ (eds) AIDS: The epidemic of Kaposi’s sarcoma and opportunistic infections. Masson, New YorkGoogle Scholar
  17. 17.
    Mildvan D, Mathur U, Enlow R et al. (1982) Persistent generalized lymphadenopathy among homosexual males. MMWR 31: 249–251Google Scholar
  18. 18.
    Metroka CE (1984) Generalized lymphadenopathy in homosexual men. In: Friedman-Kien AE, Laubenstein LJ (eds) AIDS: the epidemic of Kaposi’s sarcoma and opportunistic infections. Masson, New York, pp 73–79Google Scholar
  19. 19.
    Giraldo G, Beth E, Coeur P et al. (1972) Kaposi’s sarcoma: a new model in the search for viruses associated with human malignancies. J Natl Cancer Inst 49:1495PubMedGoogle Scholar
  20. 20.
    Haverkos HW (1987) Factors associated with the pathogenesis of AIDS. J Infect Dis 156: 251–257PubMedCrossRefGoogle Scholar
  21. 21.
    Krown SE, Real FX, Cunningham-Rundles S et al. (1983) Interferon in the treatment of Kaposi’s sarcoma. Letter to the editor. N Engl J Med 309: 923CrossRefGoogle Scholar
  22. 22.
    Groopman JE, Gottlieb MS, Goodman J et al. (1984) Recombinant alpha-2 interferon therapy for Kaposi’s sarcoma associated with the aquired immune deficiency syndrome. Ann Intern Med 100: 671PubMedGoogle Scholar
  23. 23.
    Rios A, Mansell P, Dewell G et al. (1984) The use of lymphoblastoid interferon in the treatment of acquired immunodeficiency syndrome related Kaposi’s sarcoma (abstract). Proc Am Soc Clin Oncol 3: 63Google Scholar
  24. 24.
    Fischl MA, Richman DD, Grieco MH et al. (1987) The efficacy of azidothymidine (AZT) in the treatment of patients with AIDS and AIDS-related complex. N Engl J Med 317: 185–191PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin · Heidelberg 1988

Authors and Affiliations

  • A. E. Friedman-Kien
    • 1
  1. 1.Department of Dermatology and MicrobiologyNew York University Medical CenterNew YorkUSA

Personalised recommendations