Adenosine and ATP Interactions with Autonomic Neural Control of the Heart

  • A. Pelleg
Conference paper


The purine nucleoside adenosine and its nucleotide adenosine 5′-triphosphate (ATP) are biological compounds found in every cell of the human body. Almost five decades ago Drury and Szent-Gyorgyi [34] demonstrated that in addition to their wellestablished role in cellular metabolism, adenosine and related compounds exert pronounced effects on the mammalian heart. These include coronary vasodilation, negative chronotropic effects on cardiac pacemakers, negative dromotropic effects on atrioventricular (AV) nodal conduction, and negative inotropic effect on myocardial contractility (for recent reviews, see [8, 11, 103].


Adenylate Cyclase Vagal Stimulation Sinus Node Adenosine Triphosphate Coleus Forskohlii 
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