Adenosine and ATP Interactions with Autonomic Neural Control of the Heart

  • A. Pelleg
Conference paper

Abstract

The purine nucleoside adenosine and its nucleotide adenosine 5′-triphosphate (ATP) are biological compounds found in every cell of the human body. Almost five decades ago Drury and Szent-Gyorgyi [34] demonstrated that in addition to their wellestablished role in cellular metabolism, adenosine and related compounds exert pronounced effects on the mammalian heart. These include coronary vasodilation, negative chronotropic effects on cardiac pacemakers, negative dromotropic effects on atrioventricular (AV) nodal conduction, and negative inotropic effect on myocardial contractility (for recent reviews, see [8, 11, 103].

Keywords

Respiration Prostaglandin Norepinephrine Choline Catecholamine 

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References

  1. 1.
    Akasu T, Hirai K, Koketsu K (1981) Increase in acetylcholine-receptor sensitivity by adenosine triphosphate: A novel action of ATP on ACh-sensitivity. Br J Pharmacol 74: 505–507PubMedCrossRefGoogle Scholar
  2. 2.
    Akasu T, Koketsu K (1985) Effect of adenosine triphosphate on the sensitivity of the nicotinic acetylcholine-receptor in the bullfrog sympathetic ganglion cell. Br J Pharmacol 84: 525–531PubMedCrossRefGoogle Scholar
  3. 3.
    Akasu T, Shinnick-Gallagher P, Gallagher JP (1984) Adenosine mediates slow hyperpolarizing synaptic potential in autonomic neurons. Nature 311:62–65PubMedCrossRefGoogle Scholar
  4. 4.
    Baumann G, Schrader J, Gerlach E (1981) Inhibitory action of adenosine on histamine- and dopamine-stimulated cardiac contractility and adenylate cyclase in guinea pigs. Circ Res 48: 259–266PubMedCrossRefGoogle Scholar
  5. 5.
    Belardinelli L, Isenberg G (1983) Actions of adenosine and isoproterenol on isolated mammalian ventricular myocytes. Circ Res 53: 287–297PubMedCrossRefGoogle Scholar
  6. 6.
    Belardinelli L, Mattos E, Berne RM (1981) Evidence for adenosine mediation of atrioventricular block in the ischemic canine myocardium. J Clin Invest 68:195–205PubMedCrossRefGoogle Scholar
  7. 7.
    Belardinelli L, Vogel S, Linden J, Berne RM (1982) Antiadrenergic action of adenosine on ventricular myocardium in embryonic chick hearts. J Mol Cell Cardiol 14: 291–294PubMedCrossRefGoogle Scholar
  8. 8.
    Belardinelli L, West A, Crampton R, Berne RM (1983) Chronotropic and dromotropic effects of adenosine. In: Berne RM, Rail TW, Rubio R (eds) Regulatory function of adenosine. Nijhoff, Boston, pp 377–396CrossRefGoogle Scholar
  9. 9.
    Belhassen B, Pelleg A, Shoshani D, Laniado S (1984) Atrial fibrillation induced by adenosine triphosphate. Am J Cardiol 54: 1405–1406CrossRefGoogle Scholar
  10. 10.
    Belhassen B, Pelleg A (1985) Adenosine triphosphate and adenosine: Perspectives in the acute management of paroxysmal supraventricular tachycardia. Clin Cardiol 8: 460–464PubMedCrossRefGoogle Scholar
  11. 11.
    Belhassen B, Pelleg A (1986) Electrophysiologic effects of adenosine triphosphate and adenosine on the mammalian heart: clinical and experimental aspects. J Am Coll Cardiol 2: 414–424Google Scholar
  12. 12.
    Berne RM (1963) Cardiac nucleotides in hypoxia: Possible role in regulation of coronary blood flow. Am J Physiol 204: 317–322PubMedGoogle Scholar
  13. 13.
    Bhat SV, Bajwa BS, Dornauer H, DeSouza NJ (1977) Structures and stereochemistry of new lambdane diterpenoids from coleus forskohlii brig. Tetrahedron Lett 19: 1669–1672CrossRefGoogle Scholar
  14. 14.
    Biaggioni I, Qurot J, Kincaid D, Hollister AS, Robertson D (1985) Humoral and hemodynamic effects of adenosine infusion in man (Abstr). Clin Res 33: 280AGoogle Scholar
  15. 15.
    Bohm M, Bruckner R, Hackbarth I, Haubitz B, Linhart R, Meyer W, Schmidt B, Schmitz W, Scholz H (1984) Adenosine inhibition of catecholamine-induced increase in force of contraction in guinea-pig atrial and ventricular heart preparations. Evidence against a cyclic AMP–and cyclic GMP-dependent effect. J Pharmacol Exp Ther 230: 483–492PubMedGoogle Scholar
  16. 16.
    Brown GL, Eccles JC (1934) The action of a simple vagal volley on the rhythm of the heart beat. J Physiol 82: 211PubMedGoogle Scholar
  17. 17.
    Bruckner R, Genner A, Wilfried M, Nobis TM, Schmitz W, Scholz H (1985) Cardiac effects of adenosine and adenosine analogs in guinea-pig atrial and ventricular preparations: Evidence against a role of cyclic AMP and cyclic GMP. J Pharmacol Exp Ther 234: 766–774PubMedGoogle Scholar
  18. 18.
    Burnstock G, Campbell G, Satchell D, Smythe A (1970) Evidence that adenosine triphosphate or a related nucleotide is the transmitter substance released by nonadrenergic inhibitory nerves in the gut. Br J Pharmacol 40: 668–688PubMedCrossRefGoogle Scholar
  19. 19.
    Buss DC, Routledge PA, Watt AH (1986) Intravenous adenosine stimulates respiration in conscious adult rabbits. Br J Pharmacol 87:182PGoogle Scholar
  20. 20.
    Cardenas M, Aceves J, Alarcon G (1964) Efecto del acido adenosintrifosforico sobre las propiedades fisiologicas del corazon. Arch Inst Cardiol Mex 34:485–494PubMedGoogle Scholar
  21. 21.
    Cherniack NS, Runold M, Rrabhakar NP Mitra J (1987) Effect of adenosine on vagal sensory pulmonary afferents (Abstr). Fed Proc 46: 825Google Scholar
  22. 22.
    Conradson TB, Dixon CMS, Clarke B, Barnes PJ (1986) Dipyridamole potentiates the cardiovascular effects of adenosine in man (Abstr). Pflügers Arch 407: S55CrossRefGoogle Scholar
  23. 23.
    Coumel P, Attuel P, Lavallee JP, Flammang D, Leclerq JF, Slama R (1978) Syndrome d’arythmie auriculaire d’origine vagale. Arch Mai Coeur 71: 645–656Google Scholar
  24. 24.
    Daly JW (1984) Forskolin adenylate cyclase and cell physiology: An overview. Adv Cycl Nucleotide Protein Phosphorylation Res 17: 81–89Google Scholar
  25. 25.
    Darnall RA Jr (1985) Aminophylline reduces hypoxic ventilatory depression: possible role of adenosine. Pediatr Res 19: 706–710PubMedCrossRefGoogle Scholar
  26. 26.
    Dixon CMS, Fuller RW, Hughes JMB, Maxwell DL, Nolop KB (1986) Hypoxic and hypercapnie ventilatory responses during adenosine infusion in man. J Physiol (Lond) 376: 5IPGoogle Scholar
  27. 27.
    Dobson JG Jr (1983) Adenosine reduces catecholamine contractile response in oxygenated and hypoxic atria. Am J Physiol 245: H468–H474PubMedGoogle Scholar
  28. 28.
    Dobson JG Jr (1983) Interaction between adenosine and inotropic interventions in guinea pig atria. Am J Physiol 245: H475–H480PubMedGoogle Scholar
  29. 29.
    Dobson JG Jr (1983) Mechanism of adenosine inhibition of catecholamine-induced responses in the heart. Circ Res 52: 151–160PubMedCrossRefGoogle Scholar
  30. 30.
    Dobson JG Jr, Fenton RA (1983) Antiadrenergic effects of adenosine in the hearts. In: Berne RM, Rail TW, Rubio R (eds) Regulatory function of adenosine. Nijhoff, Boston, pp 363–376CrossRefGoogle Scholar
  31. 31.
    Dobson JG Jr, Schrader J (1984) Role of extracellular and intracellular adenosine in the attenuation of catecholamine evoked responses in guinea pig heart. J Mol Cell Cardiol 16: 813–822PubMedCrossRefGoogle Scholar
  32. 32.
    Dong E Jr, Reitz BA (1970) Effects of timing of vagal stimulation on heart rate in the dog. Circ Res 27: 635–646PubMedCrossRefGoogle Scholar
  33. 33.
    Drury AN, Lutwak-Mann C, Solandt OM (1938) The inaetivation of adenosine by blood with special reference to cat’s blood. Q J Exp Physiol 27:215–236Google Scholar
  34. 34.
    Drury AN, Szent-Gyorgyi A (1929) The physiological activity of adenine compounds with especial reference to their action upon the mammalian heart. J Physiol (Lond) 68: 213–237Google Scholar
  35. 35.
    Dunwiddie TV (1985) The physiological role of adenosine in the central nervous system. Int Rev Neurobiol 27: 63–132PubMedCrossRefGoogle Scholar
  36. 36.
    Editorial (1977) Purinergic nerves. Lancet 2: 1331–1332Google Scholar
  37. 37.
    Eldridge FL, Millhorn DE, Kiley JP (1985) Antagonism by theophylline of respiratory inhibition induced by adenosine. J Appl Physiol 59: 1428–1433PubMedGoogle Scholar
  38. 38.
    Emmelin N, Feldberg W (1948) Systemic effects of adenosine triphosphate. Br J Pharmacol Chemother 3: 273–284PubMedCrossRefGoogle Scholar
  39. 39.
    Endoh M, Maruyama M, Taira N (1983) Modification by islet-activating protein of direct and indirect inhibitory actions of adenosine on rat atrial contraction in relation to cyclic nucleotide metabolism. J Cardiovasc Pharmacol 5: 131–142PubMedCrossRefGoogle Scholar
  40. 40.
    Endoh M, Maruyama M, Taira N (1983) Adenosine-induced changes in rate of beating and cyclic nucleotide levels in rat atria: modification by islet-activating protein. In: Daly JW, Kuroda Y, Phillis JW, Shimizu H, Ui M (eds) Physiology and pharmacology of adenosine derivatives. Raven, New York, pp 127–141Google Scholar
  41. 41.
    Endoh M, Yamashita S (1980) Adenosine antagonizes the positive inotropic action mediated via β- but not α-adrenoceptors in the rabbit papillary muscle. Eur J Pharmacol 65: 445–448PubMedCrossRefGoogle Scholar
  42. 42.
    Ewald DA (1976) Potentiation of postjunctional cholinergic sensitivity of rat diaphragm muscle by high energy phosphate adenine nucleotides. J Membr Biol 29: 47–65PubMedCrossRefGoogle Scholar
  43. 43.
    Fenton RA, Dobson JG Jr (1984) Adenosine and calcium alter adrenergic-induced intact heart protein phosphorylation. Am J Physiol 246: H559–H565PubMedGoogle Scholar
  44. 44.
    Forrester T, Williams CA (1977) Release of adenosine triphosphate from isolated adult heart cells in response to hypoxia. J Physiol 268: 371–390PubMedGoogle Scholar
  45. 45.
    Fredholm BB, Hedqvist P (1980) Modulation of neurotransmission by purine nucleotides and nucleosides. Biochem Pharmacol 29: 1635–1643PubMedCrossRefGoogle Scholar
  46. 46.
    Fredholm BB, Jonzon B, Lindstrom K (1986) Effect of adenosine receptor agonists and other compounds on cyclic AMP accumulation in forskolin-treated hippocampal slices. Arch Pharmacol 332: 173–178CrossRefGoogle Scholar
  47. 47.
    Fukunaga AF, Flacke VE, Bloor BC (1982) Hypotensive effects of adenosine and adenosine triphosphate compared with sodium nitroprusside. Anesth Analg 61: 273–278PubMedCrossRefGoogle Scholar
  48. 48.
    Genovese A, Levi R (1987) Adenosine modulates histamine-induced stimulation of human atrial myocarditim: protection by H1 receptor blockade. In: Pelleg A, Michelson EL, Dreifus LS (eds) Cardiac electrophysiology and pharmacology of adenosine and ATP: basic and clinical aspects. Liss, New York, pp 345–360Google Scholar
  49. 49.
    Gustafsson L (1981) Influence of adenosine on responses to vagal nerve stimulation in the anesthetized rabbit. Acta Physiol Scand 111: 263–268PubMedCrossRefGoogle Scholar
  50. 50.
    Gustafsson L, Hedqvist P, Fredholm BB, Lundgren G (1978) Inhibition of acetylcholine release in guinea pig ileum by adenosine. Acta Physiol Scand 104: 469–478PubMedCrossRefGoogle Scholar
  51. 51.
    Hall JE, Granger JP (1986) Renal hemodynamics and arterial pressure during chronic intrarenal adenosine infusion in conscious dogs. Am J Physiol 250:F32–F39PubMedGoogle Scholar
  52. 52.
    Hattori Y, Levi R (1984) Adenosine selectively attenuates H2- and beta-mediated cardiac responses to histamine and norepinephrine: an unmasking of H1 and alpha-mediated selective responses. J Pharmacol Exp Ther 231: 215–223PubMedGoogle Scholar
  53. 53.
    Hayashi E, Mori M, Yamada S, Kunitomo M (1978) Effects of purine compounds on cholinergic nerves. Specificity of adenosine and related compounds on acetylcholine release in electrically stimulated guinea pig ileum. Eur J Pharmacol 48: 297–307PubMedCrossRefGoogle Scholar
  54. 54.
    Hedqvist P, Fredholm BB (1979) Inhibitory effect of adenosine on adrenergic neuroeffector transmission in the rabbit heart. Acta Physiol Scand 105: 120–122PubMedCrossRefGoogle Scholar
  55. 55.
    Hintze TH, Belloni FL, Harrison JE, Shapiro GE (1985) Apparent reduction in barorefiex sensitivity to adenosine in conscious dogs. Am J Physiol 249: H554–H559PubMedGoogle Scholar
  56. 56.
    Hoffman WE, Satinover I, Miletich DJ, Albrecht RF, Gans BJ (1982) Cardiovascular changes during sodium nitroprusside or adenosine triphosphate infusion in the rat. Anesth Analg 61: 99–103PubMedCrossRefGoogle Scholar
  57. 57.
    Hugues FC, Jan Y, Bars V, Baubion N (1980) Etude de Faction chronotrope de l’ATP chez l’homme. Coeur Med Inter 19: 227–234Google Scholar
  58. 58.
    Imai S, Riley AL, Berne RM (1964) Effect of ischemia on adenine nucleotides in cardiac and skeletal muscle. Circ Res 15: 443–450PubMedCrossRefGoogle Scholar
  59. 59.
    Jalife J, Moe GK (1979) Phasic effects of vagal stimulation on pacemaker activity of the isolated sinus node of the young cat. Circ Res 45: 595–607PubMedCrossRefGoogle Scholar
  60. 60.
    James TN (1965) The chronotropic action of ATP and related compounds studied by direct perfusion of the sinus node. J Pharmacol Exp Ther 149: 233–247PubMedGoogle Scholar
  61. 61.
    Katholi RE, Whitlow PL, Hageman GR, Woods WT (1984) Intrarenal adenosine produces hypertension by activating the sympathetic nervous system via the renal nerves in the dog. J Hypertension 2: 349–359Google Scholar
  62. 62.
    Lagerkranser M, Irestedt L, Sollevi A, Andreen M (1984) Central and splanchnic hemodynamics in the dog during controlled hypotension with adenosine. Anesthesiology 60: 547–552PubMedCrossRefGoogle Scholar
  63. 63.
    LaMonica DA, Frohloff N, Dobson JG (1985) Adenosine inhibition of catecholamine-stimulated cardiac membrane adenylate cyclase. Am J Physiol 248: H737–H744Google Scholar
  64. 64.
    Lerman BB, Belardinelli L (1986) Effects of adenosine on ventricular tachycardia. In: Pelleg A, Michelson EL, Dreifus LS (eds) Cardiac electrophysiology and pharmacology of adenosine and ATP: basic and clinical aspects. Liss, New York, pp 301–314Google Scholar
  65. 65.
    Lerman BB, Belardinelli L, West GA, Berne RM, DiMarco JP (1986) Adenosine sensitive ventricular tachycardia: evidence suggesting cyclic AMP mediated triggered activity. Circulation 74: 270–280PubMedCrossRefGoogle Scholar
  66. 66.
    Levy MN, Martin PJ, Iano T, Zieske H (1970) Effects of single vagal stimulus on heart rate and atrioventricular conduction. Am J Physiol 281: 1256Google Scholar
  67. 67.
    Lindner E, Dohadwalla AN, Bhattacharya BK (1978) Positive inotropic and blood pressure lowering activity of a diterpene derivative isolated from coleus forskohlii: Forskolin. Arzneimittelforschung 28:284–289PubMedGoogle Scholar
  68. 68.
    Lokhandwala MF (1979) Inhibition of cardiac sympathetic neurotransmission by adenosine. Eur J Pharmacol 60: 353–357PubMedCrossRefGoogle Scholar
  69. 69.
    McQueen DS, Ribeiro JA (1981) Effect of adenosine on carotid chemoreceptor activity in the cat. Br J Pharmacol 74:129–136PubMedCrossRefGoogle Scholar
  70. 70.
    Monteiro EC, Ribeiro J A (1986) Influence of adenosine on heart responses to vagal nerve stimulation. Br J Pharmacol 87: 184PGoogle Scholar
  71. 71.
    Monteiro EC, Ribeiro JA (1987) Ventilatory effects of adenosine mediated by carotid body chemoreceptors in the rat. Arch Pharmacol 335:143–148CrossRefGoogle Scholar
  72. 72.
    Munoz A, Leenhardt A, Sassine A, Puech P (1985) Atropine antagonizes the effect of adenosine on atrioventricular conduction in closed chest dogs. Circulation 72: III–241Google Scholar
  73. 73.
    Murthy VS, Zagar ME, Vollmer RR, Schmidt DH (1982) Pentobarbital-induced changes in vagal tone and reflex vagal activity in rabbits. Eur J Pharmacol 84: 41–50PubMedCrossRefGoogle Scholar
  74. 74.
    Needleman P, Minkes MS, Douglas JR (1974) Stimulation of prostaglandin biosynthesis by adenine nucleotides. Profile of prostaglandin release by perfused organs. Circ Res 34: 455–460PubMedCrossRefGoogle Scholar
  75. 75.
    Ohnishi A, Biaggioni I, Deray G, Branch RA, Jackson EK (1986) Hemodynamic effects of adenosine in conscious spontaneously hypertensive and normotensive rats. Hypertension 8: 391–398PubMedCrossRefGoogle Scholar
  76. 76.
    Paterson ARP, Harley ER, Cass CE (1985) Measurement and inhibition of membrane transport of adenosine. In: Paton DM (ed) Methods in adenosine research. Plenum, New York, pp 165–180CrossRefGoogle Scholar
  77. 77.
    Pelleg A, Michelson EL (1987) Role of the vagus in modulation by Ca2+ of the depressant action of adenosine and adenosine 5’-triphosphate on the canine sinus node in vivo. J Auton Pharmacol 7: 127–134PubMedCrossRefGoogle Scholar
  78. 78.
    Pelleg A, Belhassen B, Ilia R, Laniado S (1985) Comparative electrophysiologic effects of ATP and adenosine in the canine heart: influence of atropine, propranolol, vagotomy, dipyridamole and aminophyiline. Am J Cardiol 55: 571–576PubMedCrossRefGoogle Scholar
  79. 79.
    Pelleg A, Mazgalev T, Price R, Dreifus LS, Michelson EL (1985) Adenosine modulation of vagal effects in the rabbit sino-atrial node. Fed Proc 44:468Google Scholar
  80. 80.
    Pelleg A, Mitamura H, Michelson EL (1985) Evidence for vagal involvement in the electrophysiologic actions of exogenous adenosine and adenosine triphosphate in the canine heart. J Auton Pharmacol 5: 207–212PubMedCrossRefGoogle Scholar
  81. 81.
    Pelleg A, Mitamura H, Mitsuoka T, Michelson EL, Dreifus LS (1986) Effects of adenosine and ATP on ventericular escape rhythm in the canine heart. J Am Coll Cardiol 8: 1145–1151PubMedCrossRefGoogle Scholar
  82. 82.
    Pelleg A, Mitsuoka T, Mazgalev T, Michelson EL (1987) Interacting negative chronotropic effects of adenosine and the vagus nerve on the canine sinus node. Cardiovasc Res (in press)Google Scholar
  83. 83.
    Pelleg A, Mitsuoka T, Michelson EL, Menduke H (1988) Adenosine mediates the negative chronotropic action of adenosine 5′-triphosphate in the canine sinus node. J Pharmacol Exp Ther 242: 791–795Google Scholar
  84. 84.
    Phillis JW, Barraco RA (1985) Adenosine, adenylate cyclase, and transmitter release. Adv Cyclic Nucleotide Protein Phosphorylation Res 19: 243–257PubMedGoogle Scholar
  85. 85.
    Puech P, Sassine A, Munoz A, Masse C, Effelmaier F, Leenhardt A, Yoshimura H (1986) Electrophysiologic effects of purines: clinical applications. In: Zipes DP, Jalife J (eds) Cardiac electrophysiology and arrhythmias. Grune and Stratton, Orlando, pp 443–450Google Scholar
  86. 86.
    Raberger G, Fischer G, Krumpl G, Schneider W, Stroibrig H (1986) Further evidence against an adenosine-catecholamine antagonism in vivo: Investigations with treadmill-exercise in dogs. Pflügers Arch 407: S16Google Scholar
  87. 87.
    Rardon DP, Bailey JC (1983) Adenosine attenuation of the electrophysiologic effects of isoproterenol on cardiac Purkinje fibers. J Pharmacol Exp Ther 228: 792–798Google Scholar
  88. 88.
    Ribeiro JA (1979) Purinergic modulation of transmitter release. J Theor Biol 80: 259–270PubMedCrossRefGoogle Scholar
  89. 89.
    Ribeiro J A, McQueen DS (1983) On the neuromuscular depression and chemoreceptor activation caused by adenosine. In: Daly JW, Kuroda Y, Phillis JW, Shimizu H, Ui M (eds) Physiology and pharmacology of adenosine. Raven, New York, pp 179–188Google Scholar
  90. 90.
    Rodger IW, Shahid M (1984) Forskolin, cyclic nucleotides and positive inotropism in isolated papillary muscles of the rabbit. Br J Pharmacol 81: 151–159PubMedCrossRefGoogle Scholar
  91. 91.
    Rossi A, Piery Y, Kreher P (1967) Modification par les nucleotides adenyliques de l’effect chronotrope de la stimulation du vague sur le coeur du rat. CR Soc Biol (Paris) 161: 860–861Google Scholar
  92. 92.
    Rubio R, Belardinelli L, Thompson CI, Berne RM (1979) Cardiac adenosine: electrophysiologic effects, possible significance in cell function, and mechanism controlling its release. In: Baer HP, Drummond GI (eds) Physiological and regulatory functions of adenosine and adenine nucleotides. Raven, New York, pp 167–182Google Scholar
  93. 93.
    Runold M, Prabhakar NR, Mitra J, Cherniack NS (1987) Adenosine stimulates respiration by acting on vagal receptors. Fed Proc 46:825Google Scholar
  94. 94.
    Samet MK, Rutledge CO (1984) Antagonism of the positive chronotropic effect of norepinephrine by purine nucleosides in rat atria. J Pharmacol Exp Ther 232: 106–110Google Scholar
  95. 95.
    Schrader J, Baumann G, Gerlach E (1977) Adenosine as an inhibitor of myocardial effects of catecholamines. Pfliigers Arch 372 99–35Google Scholar
  96. 96.
    Schrader J, Rubio R, Berne RM (1975) Inhibition of slow action potentials of guinea pig atrial muscle by adenosine: a possible effect on Ca2+ influx. J Mol Cell Cardiol 7: 427–433PubMedCrossRefGoogle Scholar
  97. 97.
    Schutz W, Tuisl E (1981) Evidence against adenylate cyclase-coupled adenosine receptors in the guinea pig heart. Eur J Pharmacol 76: 285–288PubMedCrossRefGoogle Scholar
  98. 98.
    Seitelberger R, Schutz W, Schlappack O, Raberger G (1984) Evidence against the adenosinecatecholamine antagonism under in vivo conditions. Arch Pharmacol 4325: 234–239CrossRefGoogle Scholar
  99. 99.
    Shah PK, Nalos P, Peter T (1987) Atropine resistant post infarction complete AV block: Possible role of adenosine and improvement with aminophylline. Am Heart J 113: 194–195PubMedCrossRefGoogle Scholar
  100. 100.
    Sharma AD, Milstein S, Rattes M, Klein GJ (1987) Disparate effects of adenosine triphosphate on sinus node automaticity and AV nodal conduction in man. J Am Coll Cardiol 9246AGoogle Scholar
  101. 101.
    Shinozuka K, Cheng JT, Hayashi E (1985) Effects of adenosine on contractile response of circular muscle,in electrically stimulated guinea pig ileum. Jpn J Pharmacol 38: 361–365PubMedCrossRefGoogle Scholar
  102. 102.
    Silinksy EM (1985) The biological pharmacology of calcium-dependent acetylcholine secretion. Pharmacol Rev 37: 81–132Google Scholar
  103. 103.
    Sollevi A (1986) Cardiovascular effects of adenosine in man; possible clinical implications. Prog Neurobiol 27: 319–349PubMedCrossRefGoogle Scholar
  104. 104.
    Sollevi A, Lagerkranser M, Andreen M, Irestedt L (1984) Relationship between arterial and venous adenosine levels and vasodilation during ATP- and adenosine-infusion in dogs. Acta Physiol Scand 120: 171–176PubMedCrossRefGoogle Scholar
  105. 105.
    Spear JF, Moore EN (1973) Influence of brief vagal and stellate nerve stimulation on pacemaker activity and conduction within the atrioventricular conduction system of the dog. Circ Res 32: 27–41PubMedCrossRefGoogle Scholar
  106. 106.
    Stone TW (1981) Physiological roles for adenosine and adenosine 5′-triphosphate in the nervous system. Neuroscience 6: 523–555PubMedCrossRefGoogle Scholar
  107. 107.
    Timour-Chah Q, Bertrix L, Lang J, Bouzouita K, Faucon G (1983) Enhancement by Ca2+ ions of cholinergic effects on the canine heart in situ. Arch Pharmacol 322: 59–64CrossRefGoogle Scholar
  108. 108.
    Ui M (1984) Islet-activating protein, pertussis toxin: a probe for functions of the inhibitory guanine nucleotide regulatory component of adenylate cyclase. Trends Pharmacol Sci 5: 277–279CrossRefGoogle Scholar
  109. 109.
    Watt AH, Routledge PA (1985) Adenosine stimulates respiration in man. Br J Clin Pharmacol 20:503–506PubMedCrossRefGoogle Scholar
  110. 110.
    Wayne EJ, Goodwin JF, Stoner HB (1949) The effect of adenosine triphosphate on the electrocardiogram of man and animals. Br Heart J 11: 55–67PubMedCrossRefGoogle Scholar
  111. 111.
    Webster S, Olsson RA (1981) Adenosine regulation of canine cardiac adenylate cyclase. Biochem Pharmacol 30: 369–373PubMedCrossRefGoogle Scholar
  112. 112.
    Welsley RC Jr, Boykin MT, Belardinelli L (1986) Role of adenosine as mediator of bradyarrhythmias during hypoxia in isolated guinea pig hearts. Cardiovasc Res 20: 752–759CrossRefGoogle Scholar
  113. 113.
    Welsley RC Jr, Lermann BB, DiMarco JP, Berne RM, Belardinelli L (1986) Mechanism of atropine-resistant atrioventricular block during inferior myocardial infarction: possible role of adenosine. J Am Coll Cardiol 8: 1232–1234CrossRefGoogle Scholar
  114. 114.
    Wessberg P, Hedner J, Hedner T, Presson B, Jonasson J (1985) Adenosine mechanisms in the regulation of breathing in the rat. Eur J Pharmacol 109: 659–667Google Scholar
  115. 115.
    West GA, Isenberg G, Belardinelli L (1986) Antagonism of forskolin effects by adenosine in isolated hearts and ventricular myocytes. Am J Physiol 250: H769–H777PubMedGoogle Scholar
  116. 116.
    Wu N, Armstrong I, Wagner J (1984) Genetic evidence that chloroadenosine increases the specific activity of choline acetyltransferase in PC 12 cells via modulation of an adenosinedependent adenylate cyclase. Neuroscience 13: 1365–1371PubMedCrossRefGoogle Scholar
  117. 117.
    Zafirov DH, Palmer JM, Wood JD (1985) Adenosine inhibits forskolin-induced excitation in myentric neurons. Eur J Pharmacol 113: 143–144PubMedCrossRefGoogle Scholar
  118. 118.
    Zehl U, Ritter CH, Forster W (1976) Influence of prostaglandin upon adenosine release and of adenosine upon prostaglandin release in the isolated rabbit heart. Acta Biol Med Germ 35: K77–K82PubMedGoogle Scholar

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  • A. Pelleg

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