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β-Adrenergic Receptors Subtypes in Myocardium

  • P. Robberecht
  • P. Chatelain
Part of the Update in Intensive Care and Emergency Medicine book series (UICM, volume 6)

Abstract

β-adrenergic receptors have been classified into 2 subtypes based on differences in the specificity of action of natural catecholamines [1]. For β1-adrenergic receptors, epinephrine and norepinephrine were about equivalent. In contrase, for β2-adrenergic receptors, epinephrine was considerably more potent than norepinephrine. This initial classification had survived to the screening of a large number of synthetic agonists and antagonists of increasing selectivity, and 20 years after Land’s publication, it is still obvious that only 2 subtypes of β-adrenergic receptors are present in mammalian tissues. Until the last 8 years, β1- and β2-adrenergic receptors were essentially distinguished one from the other by pharmacological studies based on the relative efficiency of selected molecules: Among the most studied are the β1-selective antagonists practolol, metoprolol and atenolol, the β2-selective agonist zinterol and the β2 selective antagonist ICI 118551. More recently, efforts have been made to distinguish the receptors on the basis of chemical and/or immunological differences [2], but it is only very recently that the complete amino-acid sequence of both β1- and β2-adrenergic receptors had definitively established that β1- and β2-adrenergic receptors were distinct chemical entities. However, the two pharmacologically distinct β1- and β2-adrenergic receptors can be found in a single tissue, subserving sometimes distinct functions, and in some cases both subtypes have been found in the same cell [3].

Keywords

Adrenergic Receptor Positive Inotropic Effect Calcium Entry Blocker Adenylate Cyclase System Adrenergic Receptor Subtype 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1988

Authors and Affiliations

  • P. Robberecht
  • P. Chatelain

There are no affiliations available

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