Role of the Liver in the Metabolism of Lipoprotein Particles

  • A. Van Tol
Conference paper
Part of the Recent Developments in Lipid and Lipoprotein Research book series (LIPID)


The liver is an important organ for lipoprotein metabolism. It is not only a major site of lipoprotein synthesis, but also the most important site of lipoprotein catabolism. Most of the apolipoproteins, as well as the cholesterol and cholesterylester moieties of all circulating plasma lipoproteins, are catabolized in the liver. This makes sense because the liver is the only organ capable of degrading substantial amounts of cholesterol. The resulting bile acids are secreted in the bile, together with undegraded cholesterol. A small part of the bile acids and cholesterol escapes the enterohepatic circulation and forms the major route of cholesterol excretion from the body.


Partial Hepatectomy High Density Lipoprotein Plasma Lipoprotein Lipid Transfer Protein Hepatic Lipase 
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© Springer-Verlag Berlin Heidelberg 1989

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  • A. Van Tol

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