Role of the Liver in the Metabolism of Lipoprotein Particles
The liver is an important organ for lipoprotein metabolism. It is not only a major site of lipoprotein synthesis, but also the most important site of lipoprotein catabolism. Most of the apolipoproteins, as well as the cholesterol and cholesterylester moieties of all circulating plasma lipoproteins, are catabolized in the liver. This makes sense because the liver is the only organ capable of degrading substantial amounts of cholesterol. The resulting bile acids are secreted in the bile, together with undegraded cholesterol. A small part of the bile acids and cholesterol escapes the enterohepatic circulation and forms the major route of cholesterol excretion from the body.
KeywordsCholesterol Sucrose Agarose Catalysis Lipase
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- 1.Alaupovic P, Tavella M, Fesmire J (1987) Separation and identification of Apo-B-containing lipoprotein particles in normolipidemic subjects and patients with hyperlipoproteinemias. In: Advances in Experimental Biology and Medicine, Vol. 210, Malmendier CL, Alaupovic P (Eds), Lipoproteins and Atherosclerosis. Plenum, New York, pp 7–14Google Scholar
- 11.Van’t Hooft FM, Van Gent T, Van Tol A (1981) Turnover and uptake by organs of radioactive serum high-density lipoprotein eholesteryl esters and phospholipids in the rat in vivo. Biochem J 196: 877–885Google Scholar
- 13.Van’t Hooft FM, Van Tol A (1985) The sites of degradation of rat high-density-lipoprotein apolipoprotein E specifically labelled with-O-(4-diazo-3-[125I]iodobenzoyl) sucrose. Biochem J 226: 715–721Google Scholar
- 16.Pittman RC, Steinberg D (1986) A novel mechanism by which high density lipoprotein selectively delivers cholesterol esters to the liver. In: Receptor-mediated uptake in the liver. Greten H, Windier E, Beisiegel U (Eds). Springer, Berlin Heidelberg New York, pp 108–119Google Scholar