Skip to main content

Turnover Studies of Apolipoproteins C: A First Critical Appraisal

  • Conference paper
Lipoprotein Subfractions Omega-3 Fatty Acids

Part of the book series: Recent Developments in Lipid and Lipoprotein Research ((LIPID))

  • 115 Accesses

Abstract

Apolipoproteins of the C group are peptides of small molecular weights, present in chylomicrons, VLDL, IDL, and HDL. These polypeptides have common characteristics: they are regulators (activators or inhibitors) of the lipid metabolism of lipoproteins, particularly the catabolism of triglyceride-rich lipoproteins [1]. The distribution of the different Apo C in lipoprotein classes varies between normal subjects and hypertriglyceridemics and in relation to fasting and the type of diet.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Schaefer EJ, Eisenberg S, Levy RI (1978) Lipoprotein apoprotein metabolism. J Lipid Res 19: 667–687

    PubMed  CAS  Google Scholar 

  2. Kashyap ML, Srivastava LS, Chen CY, Perisutti G, Campbell M, Lutmer RF, Glueck CJ (1977) Radioimmunoassay of human apolipoprotein C-II. A study in normal and hypertriglyceridemia subjects. J Clin Invest 60: 171–180

    Article  PubMed  CAS  Google Scholar 

  3. Schonfeld G, George PK, Miller J, Reilly P, Witztum J (1979) Apolipoprotein C-II and C-III levels in hyperlipoproteinemia. Metabolism 28: 1001–1010

    Article  PubMed  CAS  Google Scholar 

  4. Kashyap ML, Srivastava LS, Hynd BA, Gartside PS, Perisutti G (1981) Quantitation of human apolipoprotein C-III and its subspecies by radioimmunoassay and analytical isoelectric focusing: abnormal plasma triglyceride-rich lipoprotein apolipoprotein C-III subspecies concentrations in hypertriglyceridemia. J Lipid Res 22: 800–810

    PubMed  CAS  Google Scholar 

  5. Barr SI, Kottke BA, Mao SJT (1985) Postprandial distribution of apolipoproteins C-II and C-III in normal subjects and patients with mild hypertriglyceridemia: comparison of meals containing corn oil and medium-chain triglyceride oil. Metabolism 34: 983–992

    Article  PubMed  CAS  Google Scholar 

  6. Polz E, Kotite L, Havel RJ, Kane JP, Sata T (1980) Human apolipoprotein C-I: concentration in blood serum and lipoproteins. Biochem Med 24: 229–237

    Article  PubMed  CAS  Google Scholar 

  7. Curry MD, McConathy WJ, Fesmire JD, Alaupovic P (1980) Quantitative determination of human apolipoprotein C-III by electroimmunoassay. Biochim Biophys Acta 617: 503–513

    Article  PubMed  CAS  Google Scholar 

  8. Barr SI, Kottke B A, Chang JY, Mao SJT (1981) Immunochemistry of human plasma apolipoprotein C-II as studied by radioimmunoassay. Biochim Biophys Acta 663: 491–505

    Article  PubMed  CAS  Google Scholar 

  9. Curry MD, McConathy WJ, Fesmire JD, Alaupovic P (1981) Quantitative determination of apolipoproteins C-I and C-II in human plasma by separate electroimmunoassays. Clin Chem 27: 543–548

    PubMed  CAS  Google Scholar 

  10. Carlson LA, Holmquist L (1982) Concentrations of apolipoproteins B, C-I, C-II, C-III and E in sera from normal men and their relation to serum lipoprotein levels. Clin Chim Acta 124: 163–178

    Article  PubMed  CAS  Google Scholar 

  11. Bukberg PR, Le N-A, Ginsberg HN, Gibson JC, Goldman LC, Brown WV (1983) Direct measurement of apolipoprotein C-III specific activity in 125I-labeled very low density lipoproteins using immunoaffinity chromatography. J Lipid Res 24: 1251–1260

    PubMed  CAS  Google Scholar 

  12. Gustafson S, Ostlund-Lindqvist, Vessby B (1984) A rapid radioimmunoassay of human apolipoproteins C-II and C-III. Scand J Clin Lab Invest 44: 291–297

    Article  PubMed  CAS  Google Scholar 

  13. Weisweiler P, Schwandt P (1984) Determination of human apolipoproteins C-II and C-III by laser nephelometry. Fresenius Z Anal Chem 317: 708–709

    Article  CAS  Google Scholar 

  14. Bury J, Rosseneu M (1985) Enzyme linked immunosorbent assay for human apolipoprotein C-III. J Clin Chem Clin Biochem 23: 63–68

    PubMed  CAS  Google Scholar 

  15. Bury J, Michiels G, Rosseneu M (1986) Human apolipoprotein C-II quantitation by sandwich enzyme-linked immunosorbent assay. J Clin Chem Clin Biochem 24: 457–463

    PubMed  CAS  Google Scholar 

  16. Riesen WF, Sturzenegger E (1986) Enzyme-linked immunosorbent assay for apolipoprotein C-I. J Clin Chem Clin Biochem 24: 723–727

    PubMed  CAS  Google Scholar 

  17. Malmendier CL, Lontie J-F, Grutman GA, Delcroix C (1986) Metabolism of apolipoprotein CI, in normolipoproteinemic human subjects. Atherosclerosis 62:167–172

    Article  PubMed  CAS  Google Scholar 

  18. Malmendier CL, Lontie J-F, Grutman GA, Delcroix C (1988) Metabolism of apolipoprotein C-III in normolipemic human subjects. Atherosclerosis 69: 51–59

    Article  PubMed  CAS  Google Scholar 

  19. Kashyap ML, Srivastava LS, Hynd BA, Perisutti G, Brady DW, Gartside P, Glueck CJ (1978) The role of high density lipoprotein apolipoprotein C-II in triglyceride metabolism. Lipids 13: 933–942

    Article  PubMed  CAS  Google Scholar 

  20. Huff MW, Nestel PJ (1982) Metabolism of apolipoproteins C-H, C-nij, C-III2 and VLDL-B in human subjects consuming high carbohydrate diets. Metabolism 31: 493–498

    Article  PubMed  CAS  Google Scholar 

  21. Huff MW, Fidge NH, Nestel PJ, Billington T, Watson B (1981) Metabolism of C-apolipoproteins: kinetics of C-II, C-III1 and C-III2, and VLDL-apolipoprotein B in normal and hyperlipoproteinemic subjects. J Lipid Res 22: 1235–1246

    PubMed  CAS  Google Scholar 

  22. Berman M, Hall M III, Levy RI, Eisenberg S, Bilheimer DW, Phair RD, Goebel RH (1978) Metabolism of ApoB and ApoC lipoproteins in man: kinetic studies in normal and hyperlipoproteinemic subjects. J Lipid Res 19: 38–56

    PubMed  CAS  Google Scholar 

  23. Malmendier CL, Lontie J-F, Grutman G, Delcroix C (1987) Metabolism of apolipoprotein C: kinetic studies in human subjects: a critical review. In: Malmendier CL, Alaupovic P (eds) Lipoproteins and atherosclerosis. Plenum, New York, pp 95–103

    Chapter  Google Scholar 

  24. Berman M (1982) Kinetic analysis and modeling: theory and applications to lipoproteins. In: Berman M, Grundy SM, Howard BV (eds) Lipoprotein kinetics and modeling. Academic, New York, pp 3–36

    Google Scholar 

  25. Bukberg PR, Le N-A, Ginsberg HN, Gibson JC, Rubinstein A, Brown WV (1985) Evidence for non-equilibrating pools of apolipoprotein C-III in plasma lipoproteins. J Lipid Res 26:1047–1057

    PubMed  CAS  Google Scholar 

  26. Massey JB, Hickson D, She HS, Sparrow JT, Via DP, Gotto AM Jr, Pownall HJ (1984) Measurement and prediction rates of spontaneous transfer of phospholipids between plasma lipoproteins. Biochim Biophys Acta 794: 274–280

    Article  PubMed  CAS  Google Scholar 

  27. Tall AR (1986) Plasma lipid transfer proteins. J Lipid Res 27: 361–367

    PubMed  CAS  Google Scholar 

  28. Albers JJ, Tollefson JH, Chen C-H, Steinmetz A (1984) Isolation and characterization of human plasma lipid transfer proteins. Arteriosclerosis 4: 49–58

    Article  PubMed  CAS  Google Scholar 

  29. Dolphin PJ (1985) Lipoprotein metabolism and the role of apolipoproteins as metabolic programmers. Can J Biochem Cell Biol 63: 850–869

    Article  PubMed  CAS  Google Scholar 

  30. Tam SP, Breckenridge WC (1983) Apolipoprotein and lipid distribution between vesicles and HDL-like particles formed during lipolysis of human very low density lipoproteins by perfused rat heart. J Lipid Res 24: 1343–1357

    PubMed  CAS  Google Scholar 

  31. Schaefer EJ, Wetzel MG, Bengtsson G, Scow RO, Brewer HB Jr, Olivecrona T (1982) Transfer of human lymph chylomicron constituents to other lipoprotein density fractions during in vitro lipolysis. J Lipid Res 23: 1259–1273

    PubMed  CAS  Google Scholar 

  32. Vainio P, Virtanen JA, Kinnunen PKJ, Voyta JC, Smith LC, Gotto AM Jr, Sparrow JT, Pattus F, Verger R (1983) Action of lipoprotein lipase on phospholipid monolayers. Activation by apolipoprotein C-II. Biochemistry 22: 2270–2275

    Article  PubMed  CAS  Google Scholar 

  33. Shirai K, Fitzharris TJ, Shinomiya M, Muntz HG, Harmony JAK, Jackson RL, Quinn DM (1983) Lipoprotein lipase-catalysed hydrolysis of phosphatidylcholine of guinea pig very low density lipoproteins and discoidal complexes of phospholipid and apolipoprotein: effect of apolipoprotein C-II on the catalytic mechanism. J Lipid Res 24: 721–730

    PubMed  CAS  Google Scholar 

  34. Windier EET, Preyer S, Greten H (1986) Influence of lysophosphatidyl-choline on the C-apolipoprotein content of rat and human triglyceride-rich lipoproteins during triglyceride hydrolysis. J Clin Invest 78: 658–665

    Article  Google Scholar 

  35. Scott J, Knott TJ, Shaw DJ, Brook JD (1985) Localization of genes encoding apolipoproteins C-I, C-II, and E to the pl3-cen region of human chromosome 19. Hum Genet 71: 144–146

    Article  PubMed  CAS  Google Scholar 

  36. Law SW, Gray G, Brewer HB Jr, Sakaguchi AY, Naylor SL (1984) Human apolipoprotein A-I and C-III genes reside in the p11-q13 region of chromosome 11. Biochem Biophys Res Commun 118: 934–942

    Article  PubMed  CAS  Google Scholar 

  37. Dumon M-F, Clerc M (1986) Preliminary report on a case of apolipoproteins C-I and C-II deficiency. Clin Chim Acta 157: 239–248

    Article  PubMed  CAS  Google Scholar 

  38. Norum RA, Lakier JB, Goldstein S, Angel A, Goldberg RB, Block WD, Noffze DK, Dolphin PJ, Edelglass J, Bogorad DD, Alaupovic P (1982) Familial deficiency of apolipoproteins A-I and C-III and precocious coronary-artery disease. N Engl J Med 306: 1513–1519

    Article  PubMed  CAS  Google Scholar 

  39. Puchois P, Alaupovic P, Fruchart JC (1985) Mise au point sur les classifications des lipoprotéines plasmatiques. Ann Biol Clin (Paris) 43: 831–840

    CAS  Google Scholar 

  40. Alaupovic P, Tavella M, Fesmire J (1987) Separation and identification of Apo-B-containing lipoprotein particles in normolipidemic subjects and patients with hyperlipoproteinemias. In: Malmendier CL, Alaupovic P (eds) Lipoproteins and atherosclerosis. Plenum, New York, pp7–14

    Chapter  Google Scholar 

  41. Carlson LA, Ballantyne D (1976) Changing relative proportions of apolipoproteins C-II and C-III of very low density lipoproteins in hypertriglyceridemia. Atherosclerosis 23: 563–568

    Article  PubMed  CAS  Google Scholar 

  42. Erkelens DW, Mocking JAJ (1982) The C-II/C-III ratio of transferable apolipoprotein in primary and secondary hypertriglyceridemia. Clin Chim Acta 121: 56–65

    Article  Google Scholar 

  43. Attman PO, Gustafson A, Alaupovic P, Knight C, Wang CS, Bass H (1980) Abnormalities of plasma, lipoprotein system in patients with chronic renal failure. Circulation 62: 118

    Google Scholar 

Download references

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1989 Springer-Verlag Berlin Heidelberg

About this paper

Cite this paper

Malmendier, C.L., Lontie, JF. (1989). Turnover Studies of Apolipoproteins C: A First Critical Appraisal. In: Klör, H.U. (eds) Lipoprotein Subfractions Omega-3 Fatty Acids. Recent Developments in Lipid and Lipoprotein Research. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-83447-9_6

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-83447-9_6

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-19146-9

  • Online ISBN: 978-3-642-83447-9

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics