Abstract
The randomized clinical trial is usually the best method of comparing treatment modalities because it is unbiased. However, there is sometimes concern that the patients in the trial are not representative of all patients who could be treated. Thus, the trial results may be unbiased but not generalizable. A means of verifying the external validity of the trial is given by the comprehensive cohort study design (Olschewski and Scheurlen 1985). In this design, all available eligible patients are enrolled whether or not they consent to randomized treatment assignment. The design is essentially a prospective cohort study with a randomized subcohort.
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© 1988 Springer-Verlag Berlin · Heidelberg
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Davis, K. (1988). The Comprehensive Cohort Study: The Use of Registry Data to Confirm and Extend a Randomized Trial. In: Scheurlen, H., Kay, R., Baum, M. (eds) Cancer Clinical Trials. Recent Results in Cancer Research, vol 111. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-83419-6_17
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DOI: https://doi.org/10.1007/978-3-642-83419-6_17
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