Ewing’s Sarcoma

  • J. S. Miser
Part of the UICC International Union Against Cancer book series (UICCI)


In 1983 a study of tumor cells from both short-term tissue culture of Ewing’s sarcoma cells and from tumor cell lines derived from Ewing’s sarcoma revealed a t(11;22) chromosome translocation [1], as well as other chromosome abnormalities, often of chromosome 8. In spite of the relative constancy of these cytogenetic abnormalities, their significance is not yet known. A study of oncogene expression, translocation, and rearrangement has revealed: (a) c-sis is translocated from chromosome 22 to chromosome 11, but it is relatively distant from the breakpoint and is not expressed at high levels after translocation; (b) c-ets is located near the breakpoint on chromosome 11 and is variably expressed; (c) c-myc, present on chromosome 8, is expressed at high levels; and (d) c-myb, c-mil/raf, and c-src are all expressed and have a similar pattern to that of a related tumor, peripheral neuroepithelioma [2]. The significance of this relatively constant pattern of oncogene expression is not known at this time but it may be of diagnostic value.


Total Body Irradiation Oncogene Expression Small Round Cell Tumor Choline Acetyl Optimal Dose Intensity 
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© Springer-Verlag Berlin Heidelberg 1989

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  • J. S. Miser

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