In 1983 a study of tumor cells from both short-term tissue culture of Ewing’s sarcoma cells and from tumor cell lines derived from Ewing’s sarcoma revealed a t(11;22) chromosome translocation , as well as other chromosome abnormalities, often of chromosome 8. In spite of the relative constancy of these cytogenetic abnormalities, their significance is not yet known. A study of oncogene expression, translocation, and rearrangement has revealed: (a) c-sis is translocated from chromosome 22 to chromosome 11, but it is relatively distant from the breakpoint and is not expressed at high levels after translocation; (b) c-ets is located near the breakpoint on chromosome 11 and is variably expressed; (c) c-myc, present on chromosome 8, is expressed at high levels; and (d) c-myb, c-mil/raf, and c-src are all expressed and have a similar pattern to that of a related tumor, peripheral neuroepithelioma . The significance of this relatively constant pattern of oncogene expression is not known at this time but it may be of diagnostic value.
KeywordsToxicity Oncol Sarcoma Doxorubicin Melphalan
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