Abstract
Although colorectal cancer is a common malignancy, we have made little progress in its treatment. Several problems contribute to this situation. First, although 5-fluorouracil (5-FU) is the single most active drug for colon cancer, its effect on patient survival is marginal. Second, extensive experience has failed to show that any drug combinations are better than 5-FU alone. Third, randomized prospective trials of 5-FU alone and with other agents have not altered the natural history of surgically resected colon cancer, although the drugs are theoretically of maximum effectiveness against minimal disease. Finally, empiric testing of drug development has been a very ineffective way of identifying active new agents for colon cancer [1].
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References
Woolley PV, von Hoff DD, Kyle GW et al. (1986) Biology of colon cancer resistance to treatment. In: Mastromarino AJ (ed) Biology and treatment of colorectal cancer metastasis. Nijhoff, Boston, pp 295–309
Plowman J, Narayanan VL, Dykes D et al. (1986) Flavone acetic acid: a novel agent with preclinical antitumor activity against colon adenocarcinoma 38 in mice. Cancer Treat Rep 70: 631–635
Drewinko B, Yang L (1985) Cellular basis for the inefficacy of 5-FU in human colon carcinoma. Cancer Treat Rep 69: 1391–1398
Lokich J, Ahlgren J, Gullo J et al. (1987) A randomized trial of standard bolus 5-FU vs. protracted infusional 5-FU in advanced colon cancer. Proc ASCO 6: 81
Hohn D, Stagg R, Friedman M et al. (1987) The NCOG randomized trial of intravenous vs. hepatic arterial FuDR for colon cancer metastatic to the liver. Proc ASCO 6: 85
Sugarbaker PH, Gianola FJ, Speyer JL et al. (1985) Prospective randomized trial of intravenous vs. intraperitoneal 5-FU in patients with advanced primary colon or rectal cancer. Semin Oncol [Suppl 4] 12: 101–111
Buroker TR, Moertel, CG, Fleming TR et al. (1985) A controlled evaluation of recent approaches to biochemical modulation or enhancement of 5-fluorouracil therapy in colorectal carcinoma. J Clin Oncol 3: 1624–1631
Ortiz JE, Woolley PV (1987) A study of the synergistic effects of 5-fluorouracil and cisplatin on colon cancer cells using median effect analysis. Proc Am Assoc Cancer Res 6: 414
Glicksman AS, Lee ES, Leite D, Leith JT (1986) Production of increased cytotoxicity in human colon tumor cells after X-irradiation or drug treatment (cis-platinum, bleomycin, 5-fluorouracil) by pre-exposure to the differentiating agent N-methylformamide ( NMF ). Proc ASCO 5: 45
Dritschilo A, Grant EG, Harter KW et al. (1986) Interstitial radiation therapy for hepatic metastases: sonographic guidance for applicator placement. AJR 146: 275–278
Fojo AT, Ueda K, Slamon DJ et al. (1987) Expression of multidrug resistance gene in human tumors and tissues. Proc Natl Acad Sci USA 84: 265–269
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© 1989 Springer-Verlag Berlin Heidelberg
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Rothschild, N.E., Woolley, P.V. (1989). Colon Cancer. In: Magrath, I. (eds) New Directions in Cancer Treatment. UICC International Union Against Cancer. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-83405-9_32
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DOI: https://doi.org/10.1007/978-3-642-83405-9_32
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-19063-9
Online ISBN: 978-3-642-83405-9
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